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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 February 2010

Volume 118, Issue 1

Pages 1–64

  1. Review Article

    1. Top of page
    2. Review Article
    3. Editorial
    4. Original Articles
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      Pancreatic cysts : Preoperative diagnosis and clinical management (pages 1–13)

      Martha Bishop Pitman, Kent Lewandrowski, Jian Shen, Dushyant Sahani, William Brugge and Carlos Fernandez-del Castillo

      Article first published online: 30 DEC 2009 | DOI: 10.1002/cncy.20059

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      Patient management algorithms are evolving as more is learned about the biological behavior of neoplastic cysts of the pancreas. Cytological analysis alone suffers from relatively low sensitivity for accurate preoperative diagnosis. The authors review their multimodal approach to preoperative diagnosis of pancreatic cystic lesions that incorporates the clinical presentation of the patient with the radiological, cytological, chemical, and molecular analysis of the cyst and cyst fluid.

  2. Editorial

    1. Top of page
    2. Review Article
    3. Editorial
    4. Original Articles
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      Molecular diagnostics on thyroid fine-needle aspirations : The Pathway to Value Creation (pages 14–16)

      Douglas P. Clark

      Article first published online: 19 JAN 2010 | DOI: 10.1002/cncy.20064

      Molecular diagnostic tests performed on thyroid fine-needle aspiration may help refine the risk of malignancy in select cases. This editorial will review the steps required to bring such molecular testing from early exploratory studies to widespread implementation.

  3. Original Articles

    1. Top of page
    2. Review Article
    3. Editorial
    4. Original Articles
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      Contribution of molecular testing to thyroid fine-needle aspiration cytology of “follicular lesion of undetermined significance/atypia of undetermined significance” (pages 17–23)

      N. Paul Ohori, Marina N. Nikiforova, Karen E. Schoedel, Shane O. LeBeau, Steven P. Hodak, Raja R. Seethala, Sally E. Carty, Jennifer B. Ogilvie, Linwah Yip and Yuri E. Nikiforov

      Article first published online: 22 JAN 2010 | DOI: 10.1002/cncy.20063

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      Molecular analysis using a panel of markers detecting BRAF and RAS gene mutations and RET/PTC and PAX8/PPARγ gene rearrangements can be applied to thyroid fine-needle aspiration samples with the follicular lesion of undetermined significance/atypia of undetermined significance diagnosis. By applying these molecular techniques, follicular lesion of undetermined significance/atypia of undetermined significance cases can be further separated into very high risk and low risk categories.

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      Diagnostic accuracy and limitations of fine-needle aspiration cytology of bone and soft tissue lesions : A review of 1114 cases with cytological-histological correlation (pages 24–32)

      Walid E. Khalbuss, Lisa A. Teot and Sara E. Monaco

      Article first published online: 20 JAN 2010 | DOI: 10.1002/cncy.20058

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      The diagnosis of bone and soft tissue lesions by fine-needle aspiration (FNA) biopsy can be challenging because of overlapping cytomorphologic features, difficulties in interpretation, and sampling issues. The results of this retrospective review of a large series of bone and soft tissue FNAs show that the diagnosis of both benign and malignant lesions can be made accurately in many scenarios and also illustrates some of the pitfalls and limitations in the interpretation of these challenging cytology cases.

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      Cytological clues in the distinction between phyllodes tumor and fibroadenoma (pages 33–40)

      Imad A. El Hag, A. Aodah, S. M. Kollur, A. Attallah, A. A. E. Mohamed and H. Al-Hussaini

      Article first published online: 21 JAN 2010 | DOI: 10.1002/cncy.20057

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      Fine-needle aspiration is reliable in differentiating between phyllodes tumors and fibroadenoma with good reproducibility.

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      Does the time of day or weekday affect screening accuracy? : A pilot correlation study with cytotechnologist workload and abnormal rate detection using the ThinPrep imaging system (pages 41–46)

      Tarik M. Elsheikh, Joseph L. Kirkpatrick, Dan Fischer, Kristi D. Herbert and Andrew A. Renshaw

      Article first published online: 22 JAN 2010 | DOI: 10.1002/cncy.20060

      Time of day abnormal rate may serve as a powerful and sensitive method to measure both overall sensitivity and the effect of workload on an individual cytotechnologist's performance.

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      Diagnostic value of p16INK4A, Ki-67, and human papillomavirus L1 capsid protein immunochemical staining on cell blocks from residual liquid-based gynecologic cytology specimens (pages 47–55)

      Li Yu, Liantang Wang, Juemin Zhong and Shangwu Chen

      Article first published online: 12 JAN 2010 | DOI: 10.1002/cncy.20061

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      Immunostaining of p16INK4A and Ki-67 on a cell block preparation is helpful for improving the diagnostic accuracy of high-grade squamous intraepithelial lesion and squamous cell carcinoma. In this study, the authors observed that a combined expression pattern of p16INK4A and human papillomavirus L1 capsid protein may serve as a valuable index for prognosis prediction and follow-up of cervical dysplastic lesions.

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      “FISHing” to detect urinary and other cancers : Validation of an imaging system to aid in interpretation (pages 56–64)

      G. Denice Smith and Joel S. Bentz

      Article first published online: 22 JAN 2010 | DOI: 10.1002/cncy.20066

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      Manual interpretations and interpretations that were aided by an interactive, automated image processing and analysis system (BioView Duet) were compared in 135 cases that were processed using a proprietary bladder cancer kit for fluorescence in situ hybridization (the UroVysion Bladder Cancer Kit). The Duet imaging system-aided screens were at least equivalent to manual screens with respect to accuracy, reproducibility, and timing.

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