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Cancer Cytopathology

Cover image for Vol. 119 Issue 3

25 June 2011

Volume 119, Issue 3

Pages 141–216

  1. CytoSource

    1. Top of page
    2. CytoSource
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
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  2. Editorials

    1. Top of page
    2. CytoSource
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Critical values: We are not there yet (pages 143–144)

      Virginia A. LiVolsi

      Article first published online: 6 MAY 2011 | DOI: 10.1002/cncy.20163

      In the current and certainly future health care environment in the United States, the issue of more and better patient safety delivered in a cost-effective and efficient manner will become an essential focus. This editorial reviews the concept of “information-critical” data in anatomical pathology, both in histologic and cytologic diagnoses.

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      p16/Ki-67 dual-stain cytology in the triage of ASCUS and LSIL Papanicolaou cytology : p16/Ki-67 in cervical Papanicolaou tests (pages 145–147)

      Kristen Atkins

      Article first published online: 25 MAR 2011 | DOI: 10.1002/cncy.20139

      Cervical cancer screening continues to evolve. We may be back to embracing morphology. See related article, pp. 158-66, this issue.

  3. Review Articles

    1. Top of page
    2. CytoSource
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      From critical values to critical diagnoses : A review with an emphasis on cytopathology (pages 148–157)

      Christopher N. Chapman and Christopher N. Otis

      Article first published online: 20 APR 2011 | DOI: 10.1002/cncy.20158

      In this article, the evolution of the critical value concept is traced from clinical pathology to cytopathology. Difficulties in the meaningful application of the critical value concept in practice are reviewed along with suggestions that may enhance the operational success of critical value policies in cytopathology.

  4. Original Articles

    1. Top of page
    2. CytoSource
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      p16/ki-67 dual-stain cytology in the triage of ASCUS and LSIL Papanicolaou cytology : Results from the European Equivocal or Mildly Abnormal Papanicolaou Cytology Study (pages 158–166)

      Dietmar Schmidt, Christine Bergeron, Karin J Denton, Ruediger Ridder and for the European CINtec Cytology Study Group

      Article first published online: 25 MAR 2011 | DOI: 10.1002/cncy.20140

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      Previous p16 or Ki-67-based immunocytochemical protocols in cervical cytology required morphology interpretation of immunoreactive cells. The combination of both markers into a single test allows the detection of cervical cells simultaneously expressing both markers as morphology-independent indicators of cell-cycle deregulation. The clinical utility of this dual-stain cytology approach to triage ASCUS or LSIL Papanicolaou cytology results was shown in a large retrospective study with full disease ascertainment.

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      Performance of p16INK4a immunocytochemistry as a marker of anal squamous intraepithelial lesions (pages 167–176)

      Ivan Tramujas da Costa e Silva, Michelle Coelho Ribeiro, Felicidad Santos Gimenez, Junia Raquel Dutra Ferreira, Renata Silva Galvao, Paula Emanuelle Vasco Hargreaves, Adriana Gonçalves Daumas Pinheiro Guimaraes and Luiz Carlos de Lima Ferreira

      Article first published online: 1 MAR 2011 | DOI: 10.1002/cncy.20143

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      The utility of p16INK4a immunocytochemistry in the diagnosis of anal cancer precursor lesions is revisited. A reappraisal of the method should be undertaken to improve its diagnostic performance.

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      Equivocal cytology in lung cancer diagnosis : Improvement of diagnostic accuracy using adjuvant multicolor FISH, DNA-image cytometry, and quantitative promoter hypermethylation analysis (pages 177–192)

      Martin Schramm, Christian Wrobel, Ingmar Born, Marietta Kazimirek, Natalia Pomjanski, Marina William, Rainer Kappes, Claus Dieter Gerharz, Stefan Biesterfeld and Alfred Böcking

      Article first published online: 16 MAR 2011 | DOI: 10.1002/cncy.20142

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      To a great extent, equivocal cytology in lung cancer diagnosis can be overcome by applying adjuvant multicolor FISH, DNA-image cytometry, or quantitative promoter hypermethylation analysis, reaching sensitivities of 78%, 79%, and 49.6% in the study population, respectively (specificities, 98.2%, 98.2%, and 98.4%, respectively). A new diagnostic algorithm is presented.

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      PAX8 is expressed in pancreatic well-differentiated neuroendocrine tumors and in extrapancreatic poorly differentiated neuroendocrine carcinomas in fine-needle aspiration biopsy specimens (pages 193–201)

      Claudia M. Haynes, Ankur R. Sangoi and Reetesh K. Pai

      Article first published online: 15 FEB 2011 | DOI: 10.1002/cncy.20136

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      PAX8 is useful in distinguishing pancreatic well-differentiated neuroendocrine tumors from well-differentiated neuroendocrine tumors of other anatomic sites. In poorly differentiated neuroendocrine carcinomas, PAX8 expression is not specific for pancreatic origin and can be seen in extrapancreatic poorly differentiated neuroendocrine carcinomas.

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      DOG1 utility in diagnosing gastrointestinal stromal tumors on fine-needle aspiration (pages 202–208)

      Nazneen Fatima, Cynthia Cohen and Momin T. Siddiqui

      Article first published online: 11 MAR 2011 | DOI: 10.1002/cncy.20149

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      DOG-1 antibody has the highest sensitivity and specificity in diagnosing gastrointestinal stromal tumors in cell-block preparations. In contrast to DOG-1, C-Kit and PKCθ have a lower sensitivity and specificity for diagnosing gastrointestinal stromal tumors on fine-needle aspirations.

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      EchoBrush may be superior to standard EUS-guided FNA in the evaluation of cystic lesions of the pancreas : Preliminary experience (pages 209–214)

      Maria D. Lozano, Jose C. Subtil, Tania Labiano Miravalles, Jose I. Echeveste, Cesar Prieto, Maite Betes, F. Javier Alvarez Cienfuegos and Miguel A. Idoate

      Article first published online: 24 JAN 2011 | DOI: 10.1002/cncy.20133

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      EUS-FNA of cystic pancreatic lesions is one of the most precise methods for diagnosis but still has limited accuracy. EchoBrush appears to be superior to conventional EUS-FNA because a higher yield of epithelial cells is obtained.

  5. Correspondence

    1. Top of page
    2. CytoSource
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
    1. You have free access to this content
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