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Cancer Cytopathology

Cover image for Vol. 119 Issue 4

25 August 2011

Volume 119, Issue 4

Pages 217–289

  1. CytoSource

    1. Top of page
    2. CytoSource
    3. Review Articles
    4. Original Articles
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  2. Review Articles

    1. Top of page
    2. CytoSource
    3. Review Articles
    4. Original Articles
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      Testing for human papillomavirus in cervical cancer screening : A review of indications and methodology (pages 219–227)

      Ha Thanh Nishino, Rosemary H. Tambouret and David C. Wilbur

      Article first published online: 29 JUN 2011 | DOI: 10.1002/cncy.20161

      Various molecular techniques are currently available for detecting the presence and/or quantity of high-risk human papillomavirus (hrHPV). In this review, the testing options for hrHPV and its surrogates, with an emphasis on those approved by the US Food and Drug Administration (FDA), will be detailed.

  3. Original Articles

    1. Top of page
    2. CytoSource
    3. Review Articles
    4. Original Articles
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      Use of high-risk human papillomavirus testing in patients with low-grade squamous intraepithelial lesions (pages 228–234)

      Angelique W. Levi, Malini Harigopal, Pei Hui, Kevin Schofield and David C. Chhieng

      Article first published online: 5 JUL 2011 | DOI: 10.1002/cncy.20172

      High-risk human papillomavirus testing is highly sensitive for detecting cervical intraepithelial neoplasia 2 and more severe lesions in women with low-grade squamous intraepithelial lesions. Its use as a triaging tool may be indicated in women aged ≥ 30 years.

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      Noninvasive detection of aneuploid cells in laryngeal epithelial precursor lesions (pages 235–246)

      Tali Shani, Adi Primov-Fever, Michael Wolf, Bruria Shalmon, Ninette Amarglio, Luba Trakhtenbrot and Abraham Hirshberg

      Article first published online: 6 MAY 2011 | DOI: 10.1002/cncy.20157

      The objective of this study was to investigate the presence of chromosomal numerical aberrations in cells that were collected noninvasively from laryngeal lesions in samples that were analyzed simultaneously for morphology and fluorescence in situ hybridization. The results suggested that this technique can augment the clinical examination in predicting the nature of laryngeal lesions, avoiding unnecessary surgical interventions.

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      Fine-needle aspirations of papillary carcinoma with oncocytic features : An expanded cytologic and histologic profile (pages 247–253)

      Andrew A. Renshaw

      Article first published online: 11 MAR 2011 | DOI: 10.1002/cncy.20148

      Fine-needle aspiration of oncocytic papillary thyroid carcinoma can have a wide variety of appearances, and it may not be possible to distinguish it from Hürthle cell tumors.

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      Cytomorphologic findings of B-cell lymphomas with concurrent IGH/BCL2 and MYC rearrangements (dual-translocation lymphomas) (pages 254–262)

      Gilda da Cunha Santos, Hyang Mi Ko, Mauro Ajaj Saieg, Scott L. Boerner, Shui Wun Lai, Denis Bailey and William R. Geddie

      Article first published online: 10 MAY 2011 | DOI: 10.1002/cncy.20156

      The cytomorphologic and clinicopathologic findings of dual-translocation lymphoma were studied in different types of cytologic preparations. The results indicated that large cells with deeply basophilic cytoplasm, cytoplasmic vacuoles, and frequent segmented nuclei, especially in patients with clinically aggressive and/or unusual clinical features, should trigger a fluorescence in situ hybridization analysis for IGH/309 BCL2 and MYC gene rearrangements to identify this entity.

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      Cytopathology of “double-hit” non-Hodgkin lymphoma (pages 263–271)

      Camille T. Elkins and Paul E. Wakely Jr

      Article first published online: 10 MAY 2011 | DOI: 10.1002/cncy.20160

      B-cell lymphomas with concurrent IGH-BCL2 and c-MYC rearrangements (so-called “double-hit lymphomas” [DHL]) are a relatively rare, recently described category in the 2008 World Health Organization classification. No specific cytomorphologic feature(s) were found that reliably identified DHL, but a high Ki-67 proliferation index and positive bcl-2 stain should prompt fluorescence in situ hybridization analysis for these gene rearrangements from cytologic material.

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      Use of the monoclonal antibody MOC-31 as an immunomarker for detecting metastatic adenocarcinoma in effusion cytology (pages 272–278)

      Uma R. Kundu and Savitri Krishnamurthy

      Article first published online: 5 JUL 2011 | DOI: 10.1002/cncy.20164

      MOC-31 is a highly sensitive individual marker for distinguishing reactive mesothelial cells/mesothelioma from metastatic adenocarcinoma in effusion specimens (cell blocks or cytospin preparations). Interpreting membranous MOC-31 staining as positive for adenocarcinoma can help to prevent false-positive diagnoses and confusion between reactive mesothelial cells/mesothelioma and metastatic adenocarcinoma.

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      Digitized microscopy in the diagnosis of bladder cancer : Analysis of >3000 cases during a 7-month period (pages 279–289)

      William A. Marganski, Vanessa El-Sirgany Costa, Michael W. Kilpatrick, Triantafyllos Tafas, Joon Yim and Michael Matthews

      Article first published online: 16 MAR 2011 | DOI: 10.1002/cncy.20145

      This study demonstrates the value of an automated approach to the analysis of FISH slides. The approach affords the benefit of high-throughput while providing the necessary images and tools to quickly and accurately report a case.

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