Evaluation of chromosomal aberrations in patients with benign conditions and reactive changes in urinary cytology (pages 404–410)
Coya Tapia, Kathrina Glatz, Ellen C. Obermann, Bruno Grilli, Audrey Barascud, Michelle Herzog, René Schönegg, Spasenija Savic and Lukas Bubendorf
Article first published online: 5 JUL 2011 | DOI: 10.1002/cncy.20171
The high frequency of chromosomal polysomies in reactive urothelial cells is a potential source of false-positive fluorescence in situ hybridization results. Cells with a polyploid chromosomal pattern are of limited diagnostic value and should be interpreted in synopsis with the morphology and patient's medical history because they are common in reactive conditions.