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Cancer Cytopathology

Cover image for Vol. 120 Issue 3

25 June 2012

Volume 120, Issue 3

Pages 143–214, E1–E1

  1. CytoSource

    1. Top of page
    2. CytoSource
    3. Review Articles
    4. Commentaries
    5. Original Articles
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      A new reason to eat your veggies (page E1)

      Bryn Nelson

      Version of Record online: 12 JUN 2012 | DOI: 10.1002/cncy.21216

  2. Review Articles

    1. Top of page
    2. CytoSource
    3. Review Articles
    4. Commentaries
    5. Original Articles
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      Role of ancillary studies in fine-needle aspiration from selected tumors (pages 145–160)

      Fernando Schmitt and Helena Barroca

      Version of Record online: 1 NOV 2011 | DOI: 10.1002/cncy.20197

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      In this review, the authors address the use of immunocytochemistry and molecular techniques to refine the preoperative diagnosis and classification of lung, thyroid, kidney, and gastrointestinal cancers and soft tissue tumors. Molecular targets evaluated in cytologic material to guide treatment in colon cancer, gastrointestinal stromal tumors, and lung cancer also are reviewed.

  3. Commentaries

    1. Top of page
    2. CytoSource
    3. Review Articles
    4. Commentaries
    5. Original Articles
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      The emerging role of circulating tumor cells in breast cancer (pages 161–166)

      Savitri Krishnamurthy

      Version of Record online: 24 JAN 2012 | DOI: 10.1002/cncy.20207

      The evaluation of circulating tumor cells in peripheral blood of patients with breast cancer can be performed using different platforms. Standardization and comparison of the platforms to each other and their use in prospective clinical trials is needed for incorporation of circulating tumor cell assays into clinical practice.

  4. Original Articles

    1. Top of page
    2. CytoSource
    3. Review Articles
    4. Commentaries
    5. Original Articles
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      Optimal antigen retrieval for ethanol-fixed cytologic smears (pages 167–176)

      Tamami Denda, Shingo Kamoshida, Jumpei Kawamura, Kunihiko Harada, Kenji Kawai and Sadahito Kuwao

      Version of Record online: 20 MAR 2012 | DOI: 10.1002/cncy.21192

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      The authors demonstrate that Papanicolaou-stained, ethanol-fixed cytologic smears can be immunostained successfully with a broad panel of antibodies. However, it is emphasized that using antigen retrieval treatment on ethanol-fixed cytologic smears should be optimized for individual antibodies.

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      On-site adequacy evaluations performed by cytotechnologists : Correlation with final interpretations of 5241 image-guided fine-needle aspiration biopsies (pages 177–184)

      Oname O. Burlingame, Kessé O. Kessé, Stuart G. Silverman and Edmund S. Cibas

      Version of Record online: 31 AUG 2011 | DOI: 10.1002/cncy.20184

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      When making an on-site determination that an FNA is adequate, cytotechnologists in this laboratory were correct in 95% of cases. The highest and lowest accuracy was seen with FNABs of the liver and kidney, respectively.

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      Improvement of cellularity on cell block preparations using the so-called tissue coagulum clot method during endobronchial ultrasound-guided transbronchial fine-needle aspiration (pages 185–195)

      Rex Chin Wei Yung, Susan Otell, Peter Illei, Douglas P. Clark, David Feller-Kopman, Lonny Yarmus, Frederic Askin, Edward Gabrielson and Qing Kay Li

      Version of Record online: 5 DEC 2011 | DOI: 10.1002/cncy.20199

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      In this study, the authors compared cell block (CB) preparation using the tissue coagulum clot cell block (TCC-CB) method with the conventional normal saline needle rinse cell block method and evaluated the diagnostic rate, cellular yield, and adequacy for ancillary studies between the 2. Study data demonstrated that TCC-CB significantly increased the cellular yield of CB preparation.

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      Hormone receptor and human epidermal growth factor receptor 2 status evaluation on ThinPrep specimens from breast carcinoma : Correlation with histologic sections determination (pages 196–205)

      Enrico Pegolo, Piernicola Machin, Franca Riosa, Anna Bassini, Laura Deroma and Carla Di Loreto

      Version of Record online: 1 FEB 2012 | DOI: 10.1002/cncy.20206

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      This study validates the immunocytochemical determination of human epidermal growth factor receptor 2 (HER2) and hormone receptor status on ThinPrep-processed fine-needle aspiration cytology of breast cancer. Alcohol-based fixation seems not to affect the immunocytochemical evaluation of hormone receptor and HER2.

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      The use of FTA cards for preserving unfixed cytological material for high-throughput molecular analysis (pages 206–214)

      Mauro Ajaj Saieg, William R. Geddie, Scott L. Boerner, Ni Liu, Ming Tsao, Tong Zhang, Suzanne Kamel-Reid and Gilda da Cunha Santos

      Version of Record online: 24 JAN 2012 | DOI: 10.1002/cncy.20205

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      In the current study, high molecular weight DNA was extracted from diagnostic material remaining from fine-needle aspiration samples stored in FTA cards in sufficient amounts to perform high-throughput multiplex mutation assays. The results of this study should motivate the broad use of FTA cards as a simple and inexpensive alternative to tumor sample biobanking, increasing the effective use of limited samples for molecular analysis.

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