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Cancer Cytopathology

Cover image for Vol. 120 Issue 4

25 August 2012

Volume 120, Issue 4

Pages 215–282

  1. CytoSource

    1. Top of page
    2. CytoSource
    3. Editorials
    4. Original Articles
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  2. Editorials

    1. Top of page
    2. CytoSource
    3. Editorials
    4. Original Articles
    1. You have free access to this content
      The new generation of hepatocellular markers (pages 217–219)

      Sharon Mount

      Article first published online: 3 JUL 2012 | DOI: 10.1002/cncy.21217

      In this issue, 2 groups of authors investigate the diagnostic usefulness of the immunohistochemical marker arginase-1 in the evaluation of hepatic masses using fine-needle aspiration. Both groups propose that arginase-1 join 2 other immunohistochemical stains, hepatocyte paraffin and glypican-3, which are commonly used in the often challenging diagnosis of liver lesions.

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      Serous epithelium, serious interpretations (pages 220–222)

      Kim R. Geisinger and Graham E. Parks

      Article first published online: 23 JUL 2012 | DOI: 10.1002/cncy.21221

      The authors focus their expertise in the area of peritoneal washings on the detection of gynecologic neoplasms, specifically on the challenging area of ovarian serous tumors of low malignant potential. Particular attention is paid to the cytomorphologic differential diagnosis with endosalpingiosis; investigation of the prognostic significance of positive peritoneal washings is advanced.

  3. Original Articles

    1. Top of page
    2. CytoSource
    3. Editorials
    4. Original Articles
    1. You have full text access to this OnlineOpen article
      Arginase-1: A novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology (pages 223–229)

      Ryan McKnight, Aziza Nassar, Cynthia Cohen and Momin T. Siddiqui

      Article first published online: 1 FEB 2012 | DOI: 10.1002/cncy.21184

      Arginase-1, along with HepPar-1 and glypican-3, can be helpful in the diagnosis of hepatocellular carcinoma and its separation from metastatic carcinoma.

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      Arginase-1 is a more sensitive marker of hepatic differentiation than HepPar-1 and glypican-3 in fine-needle aspiration biopsies (pages 230–237)

      Mika Fujiwara, Shirley Kwok, Hirohisa Yano and Reetesh K. Pai

      Article first published online: 20 MAR 2012 | DOI: 10.1002/cncy.21190

      Arginase-1 is a sensitive marker of hepatic differentiation and is particularly useful in poorly differentiated hepatocellular carcinomas, which frequently lack HepPar-1 immunoreactivity.

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      Peritoneal washing cytologic analysis of ovarian serous tumors of low malignant potential to detect peritoneal implants and predict clinical outcome (pages 238–244)

      Nour Sneige, John B. Thomison, Anais Malpica, Yun Gong, Joe Ensor and Elvio G. Silva

      Article first published online: 23 JUL 2012 | DOI: 10.1002/cncy.21219

      Peritoneal washing cytology detects the presence of peritoneal implants in patients with ovarian serous tumors of low malignant potential with moderate accuracy, but it cannot distinguish between invasive and noninvasive implants. Long-term studies are needed to determine whether positive cytologic findings are an independent predictor of tumor recurrence.

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      Features associated with locoregional spread of papillary carcinoma correlate with diagnostic category in the Bethesda System for reporting thyroid cytopathology (pages 245–253)

      Paul A. VanderLaan, Ellen Marqusee and Jeffrey F. Krane

      Article first published online: 20 MAR 2012 | DOI: 10.1002/cncy.21189

      The Bethesda System for Reporting Thyroid Cytopathology predicts the presence of adverse pathological risk factors and disease progression when the malignancy is papillary thyroid carcinoma (PTC). These differences may have implications for clinical management, because malignant diagnoses identify higher risk PTCs and atypia of undetermined significance identifies mostly low-risk follicular variant PTCs.

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      Nodular lymphocyte-predominant Hodgkin lymphoma : Cytopathologic correlates on fine-needle aspiration (pages 254–260)

      Andrea P. Subhawong, Syed Z. Ali and Armanda D. Tatsas

      Article first published online: 24 FEB 2012 | DOI: 10.1002/cncy.21186

      The current series describes cytomorphologic findings of nodular lymphocyte-predominant (LP) Hodgkin lymphoma on fine-needle aspiration (FNA) with a discussion of common pitfalls and differential diagnosis. Because the entity is often mistaken for reactive lymphoid hyperplasia, a careful search using high magnification for LP cells is recommended in the evaluation of lymph node FNAs.

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      Fine-needle aspiration of intrapancreatic accessory spleen: Cytomorphologic features and differential diagnosis (pages 261–268)

      Armanda D. Tatsas, Christopher L. Owens, Momin T. Siddiqui, Ralph H. Hruban and Syed Z. Ali

      Article first published online: 1 FEB 2012 | DOI: 10.1002/cncy.21185

      Intrapancreatic accessory spleen (IPAS) is a rare benign lesion of the pancreas that frequently mimics a solid neoplasm. If IPAS is recognized as a diagnostic consideration on endoscopic ultrasound fine-needle aspiration, unnecessary surgical resection may be avoided.

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      Detection of carbonic anhydrase IX protein in the diagnosis of malignant pleural effusion by enzyme-linked immunosorbent assay and immunocytochemistry (pages 269–275)

      Nai-Ding Liao and Wen-Ying Lee

      Article first published online: 24 FEB 2012 | DOI: 10.1002/cncy.21191

      Carbonic anhydrase IX (CAIX) is a hallmark of metabolic change in cancer cells. Enzyme-linked immunosorbent assay and immunocytochemistry methods for determination of CAIX protein are potential additional tests for detection of malignant pleural effusions.

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      Value of p16INK4a in the diagnosis of low-grade urothelial carcinoma of the urinary bladder in urinary cytology (pages 276–282)

      Francesc Alameda, Nuria Juanpere, Lara Pijuan, Belen Lloveras, Javier Gimeno, Teresa Baró, Marta Salido, Sergio Serrano and Josep Lloreta

      Article first published online: 14 MAR 2012 | DOI: 10.1002/cncy.21193

      The correlation between p16INK4a immunoreactivity in urinary cytology and biopsies is reasonably strong. p16INK4a may be useful in the diagnosis and follow-up of low-grade urothelial carcinomas in urine cytology.

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