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Cancer Cytopathology

Cover image for Vol. 120 Issue 5

25 October 2012

Volume 120, Issue 5

Pages 283–357

  1. CytoSource

    1. Top of page
    2. CytoSource
    3. Editorials
    4. Commentaries
    5. Review Articles
    6. Original Articles
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  2. Editorials

    1. Top of page
    2. CytoSource
    3. Editorials
    4. Commentaries
    5. Review Articles
    6. Original Articles
    1. You have free access to this content
  3. Commentaries

    1. Top of page
    2. CytoSource
    3. Editorials
    4. Commentaries
    5. Review Articles
    6. Original Articles
    1. You have free access to this content
      Implementation of the new American Cancer Society process for creating cancer screening guidelines (pages 287–290)

      Tim Byers

      Article first published online: 19 APR 2012 | DOI: 10.1002/cncy.21198

      The American Cancer Society recently revised the methods it will use to develop cancer screening guidelines. This commentary provides a summary of those new methods, and commentary on the roles of laboratory-based specialists and cytologists in future screening guideline development.

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      p16INK4a—Is the future of cervical cancer screening rosy? (pages 291–293)

      Ann T. Moriarty

      Article first published online: 14 JUN 2012 | DOI: 10.1002/cncy.21206

      The author comments on a meta-analysis in this issue regarding cyclin-dependent kinase inhibitor 2A (p16INK4a) and the triage of women who have minimally abnormal Papanicolaou tests. The meta-analysis provides a framework for future research; however, the method is not currently ready for widespread clinical use.

  4. Review Articles

    1. Top of page
    2. CytoSource
    3. Editorials
    4. Commentaries
    5. Review Articles
    6. Original Articles
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      p16INK4a immunocytochemistry versus human papillomavirus testing for triage of women with minor cytologic abnormalities : A systematic review and meta-analysis (pages 294–307)

      Jolien Roelens, Miriam Reuschenbach, Magnus von Knebel Doeberitz, Nicolas Wentzensen, Christine Bergeron and Marc Arbyn

      Article first published online: 14 JUN 2012 | DOI: 10.1002/cncy.21205

      In this meta-analysis, the performance of cyclin-dependent kinase inhibitor 2A (p16INK4a) immunocytochemistry in the triage of women with atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion cytology is compared with Hybrid Capture 2 testing. The published literature indicates improved accuracy (similar sensitivity, higher specificity) with p16INK4a testing compared with Hybrid Capture 2 testing in the triage of atypical squamous cells of undetermined significance and higher specificity but lower sensitivity in the triage of low-grade squamous intraepithelial lesions.

  5. Original Articles

    1. Top of page
    2. CytoSource
    3. Editorials
    4. Commentaries
    5. Review Articles
    6. Original Articles
    1. You have full text access to this OnlineOpen article
      Clear cell adenocarcinoma of the lower urinary tract: Cytopathologic characteristics and differential diagnoses (pages 308–312)

      Scott A. Whitworth, Andrea P. Subhawong, Dorothy L. Rosenthal and Syed Z. Ali

      Article first published online: 19 APR 2012 | DOI: 10.1002/cncy.21197

      Clear cell adenocarcinoma of the lower urinary tract is a rare neoplasm with minimal description in the cytology literature. Three-dimensional clusters and sheets of vacuolated tumor cells with signet ring features should raise suspicion for this tumor, with a differential diagnosis including metastatic adenocarcinomas, nephrogenic adenomas, and benign glandular lesions involving the bladder and urinary tract such as mullerianosis.

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      Diagnostic value of K-ras mutation analysis for pancreaticobiliary cytology specimens with indeterminate diagnosis (pages 313–318)

      Guoping Cai, Sepi Mahooti, Fredilyn M. Lipata, David Chhieng and Pei Hui

      Article first published online: 24 FEB 2012 | DOI: 10.1002/cncy.21188

      An indeterminate cytological diagnosis is not uncommon for fine-needle aspiration and brushing cytology specimens obtained from the patients evaluated for pancreaticobiliary lesions. The results from the current study demonstrate the diagnostic value of K-ras mutation analysis in those patients with equivocal cytology diagnoses.

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      Does on-site adequacy evaluation reduce the nondiagnostic rate in endoscopic ultrasound-guided fine-needle aspiration of pancreatic lesions? (pages 319–325)

      Therese S. Cermak, Brant Wang, Pedro DeBrito, John Carroll, Nadim Haddad and Mary K. Sidawy

      Article first published online: 19 APR 2012 | DOI: 10.1002/cncy.21201

      The findings of the current study indicate that when experienced operators perform endoscopic ultrasound-guided fine-needle aspiration of the pancreas, the on-site adequacy evaluation offers no benefit in reducing the nondiagnostic rate. The authors also found that rinsing the entire sample in liquid-based media and omitting direct smears tended to improve the diagnostic rate.

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      Clinical and pathologic features and clinical impact of false negative thyroid fine-needle aspirations (pages 326–333)

      Jerome Jean-Gilles, Andrew H. Fischer, Martin H. Luu and Christopher L. Owens

      Article first published online: 23 APR 2012 | DOI: 10.1002/cncy.21196

      The clinical impact of false negative thyroid fine-needle aspiration (TFNA) is minimal in our high-volume cancer center. Cancers following false negative TFNA are of low grade, and outcomes are not adversely affected despite the delay in diagnosis. Adjusting criteria by lowering the threshold for an equivocal diagnosis to enhance the sensitivity of TFNA is therefore not justified.

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      The cytopathology of malignant peripheral nerve sheath tumor : A report of 55 fine-needle aspiration cases (pages 334–341)

      Paul E. Wakely Jr, Syed Z. Ali and Justin A. Bishop

      Article first published online: 20 MAR 2012 | DOI: 10.1002/cncy.21195

      Fine-needle aspiration cytopathology is limited as a diagnostic instrument for the initial diagnosis of malignant peripheral nerve sheath tumor (MPNST), but is exceedingly accurate and valuable in the recognition of metastatic and locally recurrent MPNST.

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      Cytomorphological and molecular genetic findings in pediatric thyroid fine-needle aspiration (pages 342–350)

      Sara E. Monaco, Liron Pantanowitz, Walid E. Khalbuss, Vanessa A. Benkovich, John Ozolek, Marina N. Nikiforova, Jeffrey P. Simons and Yuri E. Nikiforov

      Article first published online: 17 MAY 2012 | DOI: 10.1002/cncy.21199

      In this study, the utility of the new Bethesda classification system for thyroid cytology reporting and molecular testing is examined for the first time in a pediatric population. The data reveal that thyroid fine-needle aspiration in this group is a sensitive and specific tool, with a higher rate of malignancy in the atypia of undetermined significance category. The molecular findings show a higher rate of molecular abnormalities than seen in adults, and a higher prevalence of RET/PTC rearrangements than BRAF mutations, in this young age group.

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      Postradiation sarcoma: Morphological findings on fine-needle aspiration with clinical correlation (pages 351–357)

      Matthew T. Olson, Paul E. Wakely Jr, Kristy Weber, Momin T. Siddiqui and Syed Z. Ali

      Article first published online: 19 APR 2012 | DOI: 10.1002/cncy.21200

      The clinical and cytomorphologic features of postradiation sarcoma (PRS) are presented. To the authors' knowledge, the current report is the first cytomorphologic study on a series of patients with PRS.

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