Cytomorphological and molecular genetic findings in pediatric thyroid fine-needle aspiration (pages 342–350)
Sara E. Monaco, Liron Pantanowitz, Walid E. Khalbuss, Vanessa A. Benkovich, John Ozolek, Marina N. Nikiforova, Jeffrey P. Simons and Yuri E. Nikiforov
Article first published online: 17 MAY 2012 | DOI: 10.1002/cncy.21199
In this study, the utility of the new Bethesda classification system for thyroid cytology reporting and molecular testing is examined for the first time in a pediatric population. The data reveal that thyroid fine-needle aspiration in this group is a sensitive and specific tool, with a higher rate of malignancy in the atypia of undetermined significance category. The molecular findings show a higher rate of molecular abnormalities than seen in adults, and a higher prevalence of RET/PTC rearrangements than BRAF mutations, in this young age group.