Cancer Cytopathology

Copyright © 2013 American Cancer Society

Cover image for Vol. 121 Issue 2

February 2013

Volume 121, Issue 2

Pages 55–107

  1. CytoSource

    1. Top of page
    2. CytoSource
    3. Editorial
    4. Review Articles
    5. Original Articles
    1. You have free access to this content
      Targeting a murky cancer reservoir : More researchers set their sights on cancer stem cells (pages 55–56)

      Bryn Nelson

      Article first published online: 13 FEB 2013 | DOI: 10.1002/cncy.21282

  2. Editorial

    1. Top of page
    2. CytoSource
    3. Editorial
    4. Review Articles
    5. Original Articles
    1. You have free access to this content
      Pancreatic cyst fluid triage : A critical component of the preoperative evaluation of pancreatic cysts (pages 57–60)

      Martha Bishop Pitman

      Article first published online: 7 SEP 2012 | DOI: 10.1002/cncy.21227

      The realization that all neoplastic mucinous cysts have malignant potential has led to intensive evaluation of patients with both symptomatic and asymptomatic pancreatic cysts to determine the nature of the cyst and the possible need for resection. Currently, imaging and cyst fluid analyses offer the best means of accurately assessing pancreatic cysts preoperatively.

  3. Review Articles

    1. Top of page
    2. CytoSource
    3. Editorial
    4. Review Articles
    5. Original Articles
    1. You have free access to this content
      Targeting tyrosine kinases in cancer : The converging roles of cytopathology and molecular pathology in the era of genomic medicine (pages 61–71)

      Catherine I. Dumur, Michael O. Idowu and Celeste N. Powers

      Article first published online: 7 AUG 2012 | DOI: 10.1002/cncy.21225

      This review focuses on the increasingly important role of cytopathology in molecular diagnostics as the knowledge of cancer biology and signaling pathways continues to grow and as less invasive diagnostic procedures are becoming the norm. The adequacy of cytology specimens is discussed in relation to the methodological aspects of critical molecular assays in the selection of tyrosine kinase treatment for patients with cancer.

  4. Original Articles

    1. Top of page
    2. CytoSource
    3. Editorial
    4. Review Articles
    5. Original Articles
    1. Interrater agreement of anal cytology (pages 72–78)

      Teresa M. Darragh, Diane Tokugawa, Philip E. Castle, Stephen Follansbee, Sylvia Borgonovo, Brandon J. LaMere, Lauren Schwartz, Julia C. Gage, Barbara Fetterman, Thomas Lorey and Nicolas Wentzensen

      Article first published online: 18 JUL 2012 | DOI: 10.1002/cncy.21218

      Moderate to good agreement between 2 cytopathologists evaluating anal cytology samples collected from human immunodeficiency virus-positive men who have sex with men was observed. Anal cytology may be used for anal cancer screening in high-risk populations, and biomarkers of human papillomavirus-related transformation can serve as quality control for anal cytology.

    2. The role of human papillomavirus type 16/18 genotyping in predicting high-grade cervical/vaginal intraepithelial neoplasm in women with mildly abnormal Papanicolaou results (pages 79–85)

      Ming Guo, Yun Gong, Jianping Wang, Marilyn Dawlett, Shobha Patel, Ping Liu, Therese B. Bevers and Nour Sneige

      Article first published online: 5 DEC 2012 | DOI: 10.1002/cncy.21240

      Women with atypical squamous cells of unknown significance (ASCUS) and type 16 or 18 human papillomavirus (HPV) have a significantly higher rate of high-grade (grade ≥2) cervical neoplasm/vaginal intraepithelial neoplasm and carcinoma (CIN/VAIN2+) than women with ASCUS and non-16/18 HPV types. Therefore, HPV genotyping for HPV16/18 can improve risk assessment in women who have ASCUS Papanicolaou results and may be used to predict the risk of CIN/VAIN2+ and to better guide follow-up management.

    3. Optimizing the multimodal approach to pancreatic cyst fluid diagnosis : Developing a volume-based triage protocol (pages 86–100)

      Siaw Ming Chai, Karl Herba, M. Priyanthi Kumarasinghe, W. Bastiaan de Boer, Benhur Amanuel, Fabienne Grieu-Iacopetta, Ee Mun Lim, Dev Segarajasingam, Ian Yusoff, Chris Choo and Felicity Frost

      Article first published online: 7 SEP 2012 | DOI: 10.1002/cncy.21226

      A volume based protocol using different components of the 1 specimen for cytology, carcinoembryonic antigen and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation testing can optimize diagnostic yield in pancreatic cyst fluids. KRAS mutation testing adds diagnostic value to cytology and carcinoembryonic antigen analysis.

    4. Ultrasound-guided fine-needle aspiration biopsy of thyroid bed lesions from patients with thyroidectomy for thyroid carcinomas (pages 101–107)

      Lichao Zhao, Yun Gong, Jianping Wang, Marilyn Dawlett, Lei Huo, Nancy P. Caraway and Ming Guo

      Article first published online: 17 MAY 2012 | DOI: 10.1002/cncy.21202

      Ultrasound-guided thyroid bed fine-needle aspiration biopsy is an accurate and efficient tool in the triage of patients during post-thyroidectomy follow-up for recurrent thyroid carcinoma. A high diagnostic accuracy can be achieved in patients with history of papillary or medullary thyroid carcinoma (100%) as well as follicular or Hürthle cell thyroid carcinoma (93%). Caution should be taken during interpretation of fine-needle aspiration specimens that have low cellularity and lack of characteristic cytologic features of thyroid carcinoma.

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