BRAF mutation detection in indeterminate thyroid cytology specimens : Underlying cytologic, molecular, and pathologic characteristics of papillary thyroid carcinoma (pages 197–205)
N. Paul Ohori, Rashi Singhal, Marina N. Nikiforova, Linwah Yip, Karen E. Schoedel, Christopher Coyne, Kelly L. McCoy, Shane O. LeBeau, Steven P. Hodak, Sally E. Carty and Yuri E. Nikiforov
Article first published online: 7 AUG 2012 | DOI: 10.1002/cncy.21229
The BRAF mutation is found not only in malignant cytology cases but also in indeterminate thyroid cases. For these indeterminate cases with a BRAF mutation, the authors find that the specific cytology diagnoses (atypia of undetermined significance/follicular lesion of undetermined significance, follicular neoplasm/suspicious for follicular neoplasm, and suspicious for malignancy) reflect differences in the nature of cytology specimens, molecular characteristics, and histologic subtypes of papillary thyroid carcinoma.