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Cancer Cytopathology

Cover image for Vol. 121 Issue 4

April 2013

Volume 121, Issue 4

Pages 169–222

  1. CytoSource

    1. Top of page
    2. CytoSource
    3. Commentaries
    4. Review Articles
    5. Original Articles
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    2. You have free access to this content
  2. Commentaries

    1. Top of page
    2. CytoSource
    3. Commentaries
    4. Review Articles
    5. Original Articles
    1. You have free access to this content
      Are we ready to modify the Bethesda thyroid fine-needle aspiration classification scheme? (pages 171–174)

      Zubair W. Baloch, Susan J. Mandel and Virginia A. LiVolsi

      Article first published online: 6 NOV 2012 | DOI: 10.1002/cncy.21234

      The diagnostic categories in the Bethesda thyroid fine-needle aspiration classification scheme represent the best that can be accomplished on the basis of cytomorphology alone, which effectively portrays its limitations. Therefore, it will require patience from diagnosticians who play an integral part in the management of thyroid nodules, because progress in medicine and in pathology needs to proceed in small steps to avoid confusion and mistreatment of patients.

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      Can changing the terminology for benign aspirates reduce the atypia of undetermined significance/follicular lesion of undetermined significance rate in thyroid fine-needle aspirates? (pages 175–178)

      Andrew A. Renshaw and Jeffrey F. Krane

      Article first published online: 6 NOV 2012 | DOI: 10.1002/cncy.21236

      Defining 2 categories of benign thyroid aspirates may reduce the use of atypia of undetermined significance/follicular lesion of undetermined significance.

  3. Review Articles

    1. Top of page
    2. CytoSource
    3. Commentaries
    4. Review Articles
    5. Original Articles
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      The Merkel cell carcinoma challenge : A review from the fine needle aspiration service (pages 179–188)

      Charles J. Bechert, Vicki Schnadig and Ranjana Nawgiri

      Article first published online: 5 DEC 2012 | DOI: 10.1002/cncy.21237

      Merkel cell carcinoma that presents in an unusual clinical fashion or has unusual morphology poses unique diagnostic challenges. In this review, the authors present some interesting cases of this highly aggressive neoplasm that were encountered in the fine-needle aspiration service, and they review the current thinking given the new light shed on the biology of this neoplasm.

  4. Original Articles

    1. Top of page
    2. CytoSource
    3. Commentaries
    4. Review Articles
    5. Original Articles
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      A validation study of the FocalPoint GS imaging system for gynecologic cytology screening (pages 189–196)

      Terence J. Colgan, Nereo Bon, Susan Clipsham, Geoffrey Gardiner, Jeff Sumner, Virginia Walley and C. Meg McLachlin

      Article first published online: 29 JAN 2013 | DOI: 10.1002/cncy.21271

      A clinical laboratory validation study fails to demonstrate any consistent and obvious difference between the BD FocalPoint Guided Screening imaging system and routine manual screening in the detection of carcinoma, high-grade squamous intraepithelial lesion or worse, and low-grade squamous intraepithelial lesion or worse.

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      BRAF mutation detection in indeterminate thyroid cytology specimens : Underlying cytologic, molecular, and pathologic characteristics of papillary thyroid carcinoma (pages 197–205)

      N. Paul Ohori, Rashi Singhal, Marina N. Nikiforova, Linwah Yip, Karen E. Schoedel, Christopher Coyne, Kelly L. McCoy, Shane O. LeBeau, Steven P. Hodak, Sally E. Carty and Yuri E. Nikiforov

      Article first published online: 7 AUG 2012 | DOI: 10.1002/cncy.21229

      The BRAF mutation is found not only in malignant cytology cases but also in indeterminate thyroid cases. For these indeterminate cases with a BRAF mutation, the authors find that the specific cytology diagnoses (atypia of undetermined significance/follicular lesion of undetermined significance, follicular neoplasm/suspicious for follicular neoplasm, and suspicious for malignancy) reflect differences in the nature of cytology specimens, molecular characteristics, and histologic subtypes of papillary thyroid carcinoma.

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      Association of CD1a-positive dendritic cells with papillary thyroid carcinoma in thyroid fine-needle aspirations : A cytologic and immunocytochemical evaluation (pages 206–213)

      Marc P. Pusztaszeri, Peter M. Sadow and William C. Faquin

      Article first published online: 5 OCT 2012 | DOI: 10.1002/cncy.21239

      Dendritic cells (DCs) that are positive for cluster of differentiation 1a (CD1a) (a 43-49 kD protein expressed on DCs and cortical thymocytes) are present in fine-needle aspiration samples of papillary thyroid carcinoma, typically in close association with tumor cells, whereas they are rare or absent in benign thyroid nodules. In this, the first specific cytologic study of this immunologic component in fine-needle aspiration samples of papillary thyroid carcinoma, the findings suggest a possible diagnostic role for CD1a-positive DCs.

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      Analysis of tumor markers in cytological fluid obtained from computed tomography–guided needle aspiration biopsies for the diagnosis of ground-glass opacity pulmonary lesions (pages 214–222)

      Ga Ram Kim, Jin Hur, Hye-Jeong Lee, Ji Eun Nam, Young Jin Kim, Yoo Jin Hong, Hyo Sup Shim, Hee Yeong Kim, Ji Won Lee and Byoung Wook Choi

      Article first published online: 5 DEC 2012 | DOI: 10.1002/cncy.21244

      Measurement of the tumor marker cytokeratin 19 fragments (CYFRA 21-1) in cytological fluid can improve the diagnostic performance of computed tomography–guided needle aspiration biopsies for persistent ground-glass opacity pulmonary lesions. The evaluation of tumor markers in cytological fluid may be complementary to conventional means of diagnostics for persistent ground-glass opacity pulmonary lesions.

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