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Cancer Cytopathology

Cover image for Vol. 121 Issue 6

June 2013

Volume 121, Issue 6

Pages 277–338

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Commentary
    5. Original Articles
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      Issue information (pages i–iii)

      Version of Record online: 9 FEB 2016 | DOI: 10.1002/cncy.21695

  2. CytoSource

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Commentary
    5. Original Articles
    1. You have free access to this content
  3. Commentary

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Commentary
    5. Original Articles
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      The marriage of Cytology and Cytogenetics (pages 279–290)

      Paola Dal Cin, Xiaohua Qian and Edmund S. Cibas

      Version of Record online: 3 JAN 2013 | DOI: 10.1002/cncy.21270

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      The past 10 years have witnessed extraordinary advances in the field of cytogenetics with the discovery that a multitude of neoplasms is characterized by identifiable chromosomal changes. Cytology has recognized Cytogenetics as a welcome companion in the evaluation of soft tissue tumors, lymphomas, renal and urothelial tumors, and mesothelioma.

  4. Original Articles

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Commentary
    5. Original Articles
    1. You have free access to this content
      BRAF (V600E) mutation analysis on liquid-based cytology-processed aspiration biopsies predicts bilaterality and lymph node involvement in papillary thyroid microcarcinoma (pages 291–297)

      Esther Diana Rossi, Maurizio Martini, Sara Capodimonti, Celestino Pio Lombardi, Alfredo Pontecorvi, Valerio Gaetano Vellone, Gian Franco Zannoni, Luigi Maria Larocca and Guido Fadda

      Version of Record online: 28 NOV 2012 | DOI: 10.1002/cncy.21258

      The authors explore the possible application of a molecular technique to liquid-based cytology and demonstrate its simplicity and feasibility, producing good results. They also explore the role of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) gene mutations in predicting the outcome of patients who have small (≤1 cm) thyroid papillary carcinomas diagnosed on liquid-based cytology and, hence, in guiding their clinical and surgical management.

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      Cercariform cells: Another cytologic feature distinguishing solid pseudopapillary neoplasms from pancreatic endocrine neoplasms and acinar cell carcinomas in endoscopic ultrasound-guided fine-needle aspirates (pages 298–310)

      Arbaz Samad, Akeesha A. Shah, Edward B. Stelow, Mariam Alsharif, Stuart E. H. Cameron and Stefan E. Pambuccian

      Version of Record online: 5 DEC 2012 | DOI: 10.1002/cncy.21259

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      A multi-institutional review of endoscopic ultrasound-guided fine-needle aspirates from 18 pancreatic solid pseudopapillary neoplasms, 20 pancreatic endocrine neoplasms, and 4 acinar cell carcinomas indicates that these neoplasms share the following cytologic features: single cells and rosettes/acinar cell groups, round-to-plasmacytoid cells, pale-to-granular cytoplasm, fine vacuoles, and binucleated cells. Cytologic features favoring the diagnosis of solid pseudopapillary neoplasm are papillary structures, cercariform cells, large cytoplasmic vacuoles, reniform nuclei, hyaline globules/magenta-colored material, and degenerative features (cholesterol crystals, calcifications, foam cells, or giant cells).

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      High concordance of EGFR mutation status between histologic and corresponding cytologic specimens of lung adenocarcinomas (pages 311–319)

      Ping-Li Sun, Yan Jin, Hyojin Kim, Choon-Taek Lee, Sanghoon Jheon and Jin-Haeng Chung

      Version of Record online: 5 DEC 2012 | DOI: 10.1002/cncy.21260

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      Most patients with non–small cell lung carcinoma present with advanced-stage disease at the time of diagnosis, and cytologic samples represent the only material available for subsequent molecular analysis. This study demonstrates that cytologic specimens from patients with lung cancer can serve as reliable samples for the effective assessment of EGFR mutation status.

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      ProEx C as an adjunct marker to improve cytological detection of urothelial carcinoma in urinary specimens (pages 320–328)

      Neda A. Moatamed, Jian-Yu Rao, Serge Alexanian, Melissa Cobarrubias, Mary Levin, David Lu and Sophia K. Apple

      Version of Record online: 30 JAN 2013 | DOI: 10.1002/cncy.21264

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      ProEx C antibody cocktail is introduced as an adjunct immunocytochemical marker that significantly improves sensitivity and specificity of urine cytological analysis.

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      To what extent does nonanalytic reasoning contribute to visual learning in cytopathology? (pages 329–338)

      Andrew Evered, Darren Walker, Andrew A. Watt and Nick Perham

      Version of Record online: 6 FEB 2013 | DOI: 10.1002/cncy.21263

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      Nonanalytic reasoning in cytopathology image interpretation can be as accurate as traditional feature-based reasoning. Instructions to combine analytic and nonanalytic reasoning were not effective.

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