Cancer Cytopathology

Cover image for Vol. 122 Issue 12

December 2014

Volume 122, Issue 12

Pages 855–923

  1. CytoSource

    1. Top of page
    2. CytoSource
    3. Cytopathology Help Desk
    4. Review Article
    5. Original Articles
    6. Errata
    7. Thanks to Authors and Peer Reviewers
    1. You have free access to this content
  2. Cytopathology Help Desk

    1. Top of page
    2. CytoSource
    3. Cytopathology Help Desk
    4. Review Article
    5. Original Articles
    6. Errata
    7. Thanks to Authors and Peer Reviewers
  3. Review Article

    1. Top of page
    2. CytoSource
    3. Cytopathology Help Desk
    4. Review Article
    5. Original Articles
    6. Errata
    7. Thanks to Authors and Peer Reviewers
    1. You have free access to this content
      Cytopathology fellowship milestones (pages 859–865)

      Wesley Y. Naritoku and W. Stephen Black-Schaffer

      Article first published online: 18 SEP 2014 | DOI: 10.1002/cncy.21483

      There are 90 Accreditation Council for Graduate Medical Education (ACGME)-accredited cytopathology fellowship training programs in the United States, each with its own unique curriculum designed to achieve its goals and objectives. The ACGME cytopathology fellowship milestones were developed to ensure some uniformity in the outcomes of the various skill sets and competencies expected of a graduating cytopathology fellow.

  4. Original Articles

    1. Top of page
    2. CytoSource
    3. Cytopathology Help Desk
    4. Review Article
    5. Original Articles
    6. Errata
    7. Thanks to Authors and Peer Reviewers
    1. The impact of atypia/follicular lesion of undetermined significance and repeat fine-needle aspiration: 5 years before and after implementation of the Bethesda System (pages 866–872)

      Peggy S. Sullivan, Sharon L. Hirschowitz, Po Chu Fung and Sophia K. Apple

      Article first published online: 30 JUL 2014 | DOI: 10.1002/cncy.21468

      In the current study, the authors observe an increase in the percentage of atypia or follicular lesion of undetermined significance (AUS/FLUS) cases and a decrease in nondiagnostic cases with implementation of the Bethesda System for Reporting Thyroid Cytopathology. They also note more repeat fine-needle aspirations in the management of an AUS/FLUS diagnosis and an elevated malignancy risk in benign and AUS/FLUS cases associated with another AUS/FLUS diagnosis.

    2. Thyroid nodules with KRAS mutations are different from nodules with NRAS and HRAS mutations with regard to cytopathologic and histopathologic outcome characteristics (pages 873–882)

      Lisa A. Radkay, Simion I. Chiosea, Raja R. Seethala, Steven P. Hodak, Shane O. LeBeau, Linwah Yip, Kelly L. McCoy, Sally E. Carty, Karen E. Schoedel, Marina N. Nikiforova, Yuri E. Nikiforov and N. Paul Ohori

      Article first published online: 12 AUG 2014 | DOI: 10.1002/cncy.21474

      RAS mutations are found in approximately 20% to 45% of thyroid neoplasms and are associated with carcinoma in 74% to 87% of cases (most commonly follicular variant papillary thyroid carcinoma). In the current study, the authors report that subclassification of RAS mutations provides better insight into lesional characteristics. In particular, KRAS12/13-mutated thyroid nodules are associated with a lower carcinoma outcome (41.7%) and frequent oncocytic changes.

    3. Morphological parameters able to predict BRAFV600E-mutated malignancies on thyroid fine-needle aspiration cytology: Our institutional experience (pages 883–891)

      Esther Diana Rossi, Tommaso Bizzarro, Maurizio Martini, Sara Capodimonti, Guido Fadda, Luigi Maria Larocca and Fernando Schmitt

      Article first published online: 25 AUG 2014 | DOI: 10.1002/cncy.21475

      The BRAFV600E mutation is a strong indicator of papillary thyroid carcinoma. Its evaluation is typically performed with DNA-based techniques; nonetheless, a few articles have recently proposed its morphological prediction. The detection of specific mutational cellular details on fine-needle aspiration cytology might be a valid alternative to DNA-based methods with reliable results.

    4. The role of SOX11 immunostaining in confirming the diagnosis of mantle cell lymphoma on fine-needle aspiration samples (pages 892–897)

      Y. Helen Zhang, Joe Liu, Marilyn Dawlett, Ming Guo, Xiaoping Sun and Yun Gong

      Article first published online: 23 JUL 2014 | DOI: 10.1002/cncy.21465

      SOX11 immunostaining on fine-needle aspiration samples is highly accurate for mantle cell lymphoma. The staining can be used as a reliable adjunct to confirm mantle cell lymphoma.

    5. The usefulness of the cell transfer technique for immunocytochemistry of fine-needle aspirates (pages 898–902)

      Ann E. Marshall, Harvey M. Cramer and Howard H. Wu

      Article first published online: 30 JUL 2014 | DOI: 10.1002/cncy.21469

      In the authors' experience with performing immunocytochemistry through the cell transfer technique, a total of 118 of 11,259 fine-needle aspiration cases (1%) studied were found to demonstrate useful information that contributed to the final diagnosis.

    6. Cytologic characterization of atypical teratoid/rhabdoid tumor in cerebrospinal fluid (pages 903–908)

      Eric C. Huang, Miguel A. Guzman, Umberto De Girolami and Edmund S. Cibas

      Article first published online: 4 AUG 2014 | DOI: 10.1002/cncy.21470

    7. Influence of knowledge of human immunodeficiency virus serostatus on accuracy of cervical cytologic diagnosis (pages 909–913)

      Louis-Jacques van Bogaert

      Article first published online: 29 SEP 2014 | DOI: 10.1002/cncy.21487

      Women infected with the human immunodeficiency virus are at high risk of human papillomavirus-related preinvasive and invasive cervical lesions. Knowledge of a patient's human immunodeficiency virus serostatus may lead to cytologic overdiagnosis, resulting in unnecessary interventions.

    8. Interobserver reproducibility and accuracy of p16/Ki-67 dual-stain cytology in cervical cancer screening (pages 914–920)

      Nicolas Wentzensen, Barbara Fetterman, Diane Tokugawa, Mark Schiffman, Philip E. Castle, Shannon N. Wood, Eric Stiemerling, Nancy Poitras, Thomas Lorey and Walter Kinney

      Article first published online: 12 AUG 2014 | DOI: 10.1002/cncy.21473

      The authors evaluate the reproducibility and accuracy of p16/Ki-67 dual-stain cytology among 10 newly trained evaluators. The results indicate that the evaluation of p16/Ki-67 dual staining on cytology slides can be implemented in routine cytology practice with limited training and good to excellent reproducibility.

  5. Errata

    1. Top of page
    2. CytoSource
    3. Cytopathology Help Desk
    4. Review Article
    5. Original Articles
    6. Errata
    7. Thanks to Authors and Peer Reviewers
    1. You have free access to this content
    2. You have free access to this content
  6. Thanks to Authors and Peer Reviewers

    1. Top of page
    2. CytoSource
    3. Cytopathology Help Desk
    4. Review Article
    5. Original Articles
    6. Errata
    7. Thanks to Authors and Peer Reviewers
    1. You have free access to this content

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