p16INK4a overexpression and p16/Ki-67 dual labeling versus conventional urinary cytology in the evaluation of urothelial carcinoma (pages 211–220)
Eric Piaton, Christian Carré, Anne-Sophie Advenier, Myriam Decaussin-Petrucci, Florence Mège-Lechevallier, Philippe Lantier, Guillaume Granier and Alain Ruffion
Article first published online: 2 DEC 2013 | DOI: 10.1002/cncy.21376
Overexpression of p16INK4a has been reported in 80% of high-grade urothelial lesions. In gynecologic pathology, p16/Ki-67 dual labeling provides high sensitivity for the detection of biopsy-confirmed high-grade lesions. The results of the current study indicate that p16/Ki-67 dual labeling and conventional urinary cytology demonstrate comparable performance in the assessment of urothelial malignancies.