Cancer Cytopathology

Cover image for Vol. 122 Issue 4

April 2014

Volume 122, Issue 4

Pages 237–312

  1. CytoSource

    1. Top of page
    2. CytoSource
    3. Clinician's Corner
    4. Review Article
    5. Original Articles
    1. You have free access to this content
  2. Clinician's Corner

    1. Top of page
    2. CytoSource
    3. Clinician's Corner
    4. Review Article
    5. Original Articles
  3. Review Article

    1. Top of page
    2. CytoSource
    3. Clinician's Corner
    4. Review Article
    5. Original Articles
    1. Hürthle cells in fine-needle aspirates of the thyroid: A review of their diagnostic criteria and significance (pages 241–249)

      Manon Auger

      Article first published online: 16 JAN 2014 | DOI: 10.1002/cncy.21391

      While giving some historical perspectives, this review aims to emphasize the diagnostic criteria and the significance of Hüurthle cells in fine-needle aspirates of the thyroid.

  4. Original Articles

    1. Top of page
    2. CytoSource
    3. Clinician's Corner
    4. Review Article
    5. Original Articles
    1. Stability of human papillomavirus (HPV) in cervical ThinPrep specimens previously lysed with glacial acetic acid: Effect on cobas 4800 HPV test performance (pages 250–256)

      Mary McMenamin and Michael McKenna

      Article first published online: 3 DEC 2013 | DOI: 10.1002/cncy.21377

      Retrospective human papillomavirus testing of ThinPrep samples that have been previously lysed with glacial acetic acid is reliable. Hologic's glacial acetic acid lysing procedure for ThinPrep specimens can be reliably modified to optimize samples for human papillomavirus testing.

    2. You have free access to this content
      MYB immunostaining is a useful ancillary test for distinguishing adenoid cystic carcinoma from pleomorphic adenoma in fine-needle aspiration biopsy specimens (pages 257–265)

      Marc P. Pusztaszeri, Peter M. Sadow, Aya Ushiku, Patrizia Bordignon, Thomas A. McKee and William C. Faquin

      Article first published online: 2 DEC 2013 | DOI: 10.1002/cncy.21381

      The authors assess the expression of MYB in fine-needle aspiration biopsy (FNAB) specimens, in corresponding resection specimens of adenoid cystic carcinoma (ACC), and in a control group of pleomorphic adenoma (PA) specimens using immunocytochemistry with a commercially available anti-MYB monoclonal antibody. A majority of ACCs have strong immunoreactivity for MYB, whereas all PA FNABs were negative. This ancillary test is more effective in alcohol-fixed FNAB specimens than in corresponding formalin-fixed, paraffin-embedded tissue from surgical resections, and the authors conclude that MYB can be a useful ancillary test for the distinction of ACC from PA on FNABs.

    3. Comparison of fine-needle aspiration and fine-needle capillary sampling of thyroid nodules: A prospective study with emphasis on the influence of nodule size (pages 266–273)

      Jian-Qiao Zhou, Jing-Wen Zhang, Wei-Wei Zhan, Wei Zhou, Ting-Jun Ye, Ying Zhu, Jie-Jie Yao, Jun Liu, Yun-Yun Hu and Edward G. Grant

      Article first published online: 3 DEC 2013 | DOI: 10.1002/cncy.21382

      Fine-needle aspiration may be more suitable than fine-needle capillary sampling for thyroid nodules that measure from 5.1 to 10.0 mm and 20.0 mm. For nodules that measure from 10.1 to 20.0 mm and 5.0 mm, the 2 techniques may yield specimens with similar quality.

    4. A 4-MicroRNA signature can discriminate primary lymphomas from anaplastic carcinomas in thyroid cytology smears (pages 274–281)

      Ambrogio Fassina, Rocco Cappellesso, Francesca Simonato, Maayan Siri, Laura Ventura, Francesca Tosato, Lill-Tove Busund, Maria Rosa Pelizzo and Matteo Fassan

      Article first published online: 10 DEC 2013 | DOI: 10.1002/cncy.21383

      Histotype-specific microRNA signatures can provide new insight into the molecular mechanisms of thyroid carcinogenesis. The tested signature of 4 microRNAs in this study is a promising diagnostic tool for differentiating anaplastic thyroid lymphoma from primary thyroid lymphoma and non-neoplastic multinodular goiter, even in the presence of scant material obtained from minimally invasive procedures.

    5. Performance characteristics of ultrasound-guided fine-needle aspiration of axillary lymph nodes for metastatic breast cancer employing rapid on-site evaluation of adequacy: Analysis of 136 cases and review of the literature (pages 282–291)

      Adele D. Fung, Jennifer A. Collins, Christina Campassi, Olga B. Ioffe and Paul N. Staats

      Article first published online: 18 DEC 2013 | DOI: 10.1002/cncy.21384

      Ultrasound-guided fine-needle aspiration of axillary lymph nodes is moderately sensitive and highly specific for the detection of metastatic breast cancer, and most false-negative results are due to small metastatic foci. Rapid on-site evaluation for adequacy improves the rate of definitive diagnoses.

    6. mRNA and miRNA analyses in cytologically positive endobronchial ultrasound-guided transbronchial needle aspiration: Implications for molecular staging in lung cancer patients (pages 292–298)

      Till Plönes, Mirjam Elze, Gian Kayser, Dietmar Pfeifer, Meike Burger and Gernot Zissel

      Article first published online: 26 FEB 2014 | DOI: 10.1002/cncy.21398

      miRNA may be suitable to improve molecular mediastinal staging in lung cancer patients.

    7. Claudin-4 immunohistochemistry is highly effective in distinguishing adenocarcinoma from malignant mesothelioma in effusion cytology (pages 299–306)

      Vickie Y. Jo, Edmund S. Cibas and Geraldine S. Pinkus

      Article first published online: 13 JAN 2014 | DOI: 10.1002/cncy.21392

      Adenocarcinoma can be challenging to distinguish from malignant mesothelioma in effusion cytology. In a large series of malignant effusions, this study demonstrated that claudin-4 immunohistochemistry effectively distinguishes adenocarcinoma from malignant mesothelioma with high sensitivity and specificity.

    8. GATA3: A promising marker for metastatic breast carcinoma in serous effusion specimens (pages 307–312)

      Paul W. Shield, David J. Papadimos and Michael D. Walsh

      Article first published online: 13 JAN 2014 | DOI: 10.1002/cncy.21393

      This preliminary investigation of GATA-binding protein 3 to DNA sequence [A/T]GATA[A/G] (GATA3) staining of cell block specimens found high sensitivity (90%) and specificity for metastatic breast carcinoma. The sensitivity was superior to both mammaglobin and gross cystic disease fluid protein of 15 kilodaltons (GCDFP-15).

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