Cancer Cytopathology

Cover image for Vol. 122 Issue 5

May 2014

Volume 122, Issue 5

Pages 313–393

  1. CytoSource

    1. Top of page
    2. CytoSource
    3. Clinician's Corner
    4. Commentary
    5. Review Article
    6. Point/Counterpoint
    7. Original Articles
    1. You have free access to this content
  2. Clinician's Corner

    1. Top of page
    2. CytoSource
    3. Clinician's Corner
    4. Commentary
    5. Review Article
    6. Point/Counterpoint
    7. Original Articles
  3. Commentary

    1. Top of page
    2. CytoSource
    3. Clinician's Corner
    4. Commentary
    5. Review Article
    6. Point/Counterpoint
    7. Original Articles
  4. Review Article

    1. Top of page
    2. CytoSource
    3. Clinician's Corner
    4. Commentary
    5. Review Article
    6. Point/Counterpoint
    7. Original Articles
    1. Cytopathology of pediatric malignancies: Where are we today with fine-needle aspiration biopsies in pediatric oncology? (pages 322–336)

      Sara E. Monaco and Lisa A. Teot

      Article first published online: 6 MAR 2014 | DOI: 10.1002/cncy.21401

      Childhood malignancies are infrequent and differ from adult malignancies clinically and pathologically. This review discusses childhood malignancies, focusing on their frequency in different age groups, representation in cytologic specimens in different geographic regions, the use of cytopathology as a diagnostic tool in the United States, and cytological features of selected tumors using a pattern-based approach.

  5. Point/Counterpoint

    1. Top of page
    2. CytoSource
    3. Clinician's Corner
    4. Commentary
    5. Review Article
    6. Point/Counterpoint
    7. Original Articles
  6. Original Articles

    1. Top of page
    2. CytoSource
    3. Clinician's Corner
    4. Commentary
    5. Review Article
    6. Point/Counterpoint
    7. Original Articles
    1. Reprocessing unsatisfactory ThinPrep Papanicolaou tests using a modified SurePath preparation technique (pages 343–348)

      Melissa L. Randolph, Howard H. Wu and William N. Crabtree

      Article first published online: 20 FEB 2014 | DOI: 10.1002/cncy.21408

      The modified SurePath processing method was found to be adept at handling nearly all of the challenges that biological and environmental conditions (blood, protein, lubricant, etc) present in unsatisfactory liquid-based filter preparations. A total of 1093 (56%) of 1937 unsatisfactory ThinPrep Papanicolaou tests were converted to a satisfactory state, resulting in the diagnosis of 116 abnormalities (10.6%) that otherwise would have gone undetected.

    2. Isthmic-vaginal smear cytology in the follow-up after radical vaginal trachelectomy for early stage cervical cancer: Is it safe? (pages 349–358)

      Malgorzata Lanowska, Mandy Mangler, Ulrike Grittner, Gerta Rose Akbar, Dorothee Speiser, Elisabeth von Tucher, Christhardt Köhler, Achim Schneider and Wolfgang Kühn

      Article first published online: 29 JAN 2014 | DOI: 10.1002/cncy.21402

      Isthmic-vaginal cytology is useful in the follow-up of patients after fertility-preserving surgery for early cervical cancer as recurrent dysplasia and malignancy in the remaining cervix may be diagnosed. Improved communication between cytopathologists and clinicians and a modification of the surgical technique may help to achieve more valuable smears.

    3. You have free access to this content
      The role of thyroid fine-needle aspiration cytology in the pediatric population: An institutional experience (pages 359–367)

      Esther Diana Rossi, Patrizia Straccia, Maurizio Martini, Luca Revelli, Celestino Pio Lombardi, Alfredo Pontecorvi and Guido Fadda

      Article first published online: 28 JAN 2014 | DOI: 10.1002/cncy.21400

      The current study evaluates the authors' pediatric thyroid series with cytohistological control to analyze the distribution of the diagnostic categories and the role of a well-known immunocytochemical panel. The higher incidence of histological malignancies justifies the cytological application of ancillary techniques, thereby enabling a more adequate surgical selection for the categories of follicular/indeterminate neoplasm including atypical cells of indeterminate significance and suspicious for malignancy.

    4. The prediction of malignant risk in the category “atypia of undetermined significance/follicular lesion of undetermined significance” of the Bethesda System for Reporting Thyroid Cytopathology using subcategorization and BRAF mutation results (pages 368–376)

      Jiyeon Hyeon, Soomin Ahn, Jung Hee Shin and Young Lyun Oh

      Article first published online: 3 MAR 2014 | DOI: 10.1002/cncy.21396

      The subcategory “AUS” indicates a higher risk of malignancy than the subcategory “FLUS.” Furthermore, BRAF molecular testing is helpful in stratifying the malignant risk of AUS cases into high-risk and low-risk groups.

    5. You have full text access to this OnlineOpen article
      Optimizing detection of RET and PPARg rearrangements in thyroid neoplastic cells using a home-brew tetracolor probe (pages 377–385)

      Paola Caria, Daniela V. Frau, Tinuccia Dettori, Francesco Boi, Maria L. Lai, Stefano Mariotti and Roberta Vanni

      Article first published online: 7 FEB 2014 | DOI: 10.1002/cncy.21397

      A home-brew tetracolor FISH probe for the simultaneous detection of RET/PTC and PAX8/PPARg alterations in thyroid nodule FNA is reported. Application of the probe on 368 FNA samples demonstrated feasibility, suggesting that this probe may be considered an alternative to the RT-PCR assay when recovery and quality of RNA amplification from FNA is limited.

    6. Fine-needle aspiration in desmoplastic small round cell tumor: A report of 10 new tumors in 8 patients with clinicopathological and molecular correlations with review of the literature (pages 386–393)

      Jerzy Klijanienko, Pierre Colin, Jérôme Couturier, Réal Lagacé, Paul Fréneaux, Gaëlle Pierron, Marick Laé, Alice Klijanienko, Hervé Brisse, Daniel Orbach and Stamatios Theocharis

      Article first published online: 17 MAR 2014 | DOI: 10.1002/cncy.21415

      The combination of smears showing poorly differentiated round cell morphology, cytoplasmic paranuclear densities, presence of connective fragments, specific clinical context, young adult/pediatric age, intra-abdominal localization, specific immunohistochemical profile, and unique cytogenetic abnormality are highly specific for desmoplastic small round cell tumor and allow an accurate diagnosis.

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