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Cancer Cytopathology

Cover image for Vol. 122 Issue 6

June 2014

Volume 122, Issue 6

Pages 395–475

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Clinician's Corner
    5. Review Article
    6. Original Articles
    7. Correspondence
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      Issue information (pages i–iv)

      Version of Record online: 4 AUG 2015 | DOI: 10.1002/cncy.21593

  2. CytoSource

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Clinician's Corner
    5. Review Article
    6. Original Articles
    7. Correspondence
    1. You have free access to this content
  3. Clinician's Corner

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Clinician's Corner
    5. Review Article
    6. Original Articles
    7. Correspondence
    1. You have free access to this content
  4. Review Article

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Clinician's Corner
    5. Review Article
    6. Original Articles
    7. Correspondence
    1. You have free access to this content
      Guidelines for pancreaticobiliary cytology from the Papanicolaou Society of Cytopathology: A review (pages 399–411)

      Martha B. Pitman and Lester J. Layfield

      Version of Record online: 28 APR 2014 | DOI: 10.1002/cncy.21427

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      This review provides a synopsis of the recent guidelines for pancreaticobiliary cytology from the Papanicolaou Society of Cytopathology addressing indications, techniques, terminology and nomenclature, ancillary studies, and postprocedure management of patients with lesions of the pancreas and bile ducts.

  5. Original Articles

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Clinician's Corner
    5. Review Article
    6. Original Articles
    7. Correspondence
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      Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) contributes to a triple-negative test in preoperative screening of pancreatic cysts (pages 412–419)

      Roseann I. Wu, Won Jae Yoon, William R. Brugge, Mari Mino-Kenudson and Martha B. Pitman

      Version of Record online: 10 DEC 2013 | DOI: 10.1002/cncy.21385

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      Endoscopic ultrasound-guided fine-needle aspiration is a screening test that contributes to a triple-negative result for pancreatic cysts—no high-risk stigmata, no worrisome features, and no high-grade atypia on cytology—providing a high negative predictive value for conservative management.

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      Malignancy risk associated with diagnostic categories defined by the Papanicolaou Society of Cytopathology pancreaticobiliary guidelines (pages 420–427)

      Lester J. Layfield, Leslie Dodd, Rachel Factor and Robert L. Schmidt

      Version of Record online: 11 DEC 2013 | DOI: 10.1002/cncy.21386

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      The diagnostic categories of the Papanicolaou Society of Cytopathology stratify risk of malignancy. An increasing risk of malignancy is associated with progression through the categories “benign,” “atypical,” “suspicious for malignancy,” and “malignant.”

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      Atypical cytologic diagnostic category in EUS-FNA of the pancreas: Follow-up, outcomes, and predictive models (pages 428–434)

      Evan Alston, Sejong Bae and Isam A. Eltoum

      Version of Record online: 16 JAN 2014 | DOI: 10.1002/cncy.21389

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      This study assessed the outcomes of the atypical diagnostic category in EUS-FNA of the pancreas and developed a predictor model to determine which factors are likely to be associated with pancreatic neoplasm or ductal carcinoma following this diagnosis.

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      Cystic pancreatic neuroendocrine tumors: The value of cytology in preoperative diagnosis (pages 435–444)

      Vicente Morales-Oyarvide, Won Jae Yoon, Thun Ingkakul, David G. Forcione, Brenna W. Casey, William R. Brugge, Carlos Fernández-del Castillo and Martha B. Pitman

      Version of Record online: 3 MAR 2014 | DOI: 10.1002/cncy.21403

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      Cytopathology is the most accurate test for the preoperative diagnosis of cystic pancreatic neuroendocrine tumors. Endoscopic ultrasound is insufficiently accurate for independent diagnosis, and carcinoembryonic antigen and amylase analyses are noncontributory.

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      Anaplastic lymphoma kinase gene rearrangements in cytological samples of non–small cell lung cancer: Comparison with histological assessment (pages 445–453)

      Agnese Proietti, Greta Alì, Serena Pelliccioni, Cristiana Lupi, Elisa Sensi, Laura Boldrini, Adele Servadio, Antonio Chella, Alessandro Ribechini, Federico Cappuzzo, Mario Miccoli and Gabriella Fontanini

      Version of Record online: 19 MAR 2014 | DOI: 10.1002/cncy.21418

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      Anaplastic lymphoma kinase (ALK) rearrangement is present in 2% to 7% of cases of non-small cell lung cancer. Fluorescence in situ hybridization is currently the elective method for their detection. Although this assay has been approved on histological samples, its usefulness in detecting ALK gene rearrangements in cytological specimens has not been assessed fully. The authors found that ALK gene rearrangement may be easily detected in cytological samples and particularly in direct smears. Moreover, cytological samples may be useful for ALK analysis when insufficient material is available in cell blocks or small biopsy samples.

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      Molecular testing in lung cancer: Fine-needle aspiration specimen adequacy and test prioritization prior to the CAP/IASLC/AMP Molecular Testing Guideline publication (pages 454–458)

      Oana C. Rafael, Mohamed Aziz, Harry Raftopoulos, Oana E. Vele, Weisheng Xu and Chiara Sugrue

      Version of Record online: 10 APR 2014 | DOI: 10.1002/cncy.21426

      The current study underscores the need for a testing prioritization algorithm in view of the College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology 2013 Molecular Testing Guideline publication to optimize usage of fine-needle aspiration material for both diagnostic and therapy guidance purposes. Implementation of an institution-wide algorithm would serve as a helpful reference for both clinicians and pathologists.

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      Comparison of urine cytology and fluorescence in situ hybridization in upper urothelial tract samples (pages 459–467)

      Jordan P. Reynolds, Jesse S. Voss, Benjamin R. Kipp, R. Jeffrey Karnes, Aziza Nassar, Amy C. Clayton, Michael R. Henry, Thomas J. Sebo, Jun Zhang and Kevin C. Halling

      Version of Record online: 6 MAR 2014 | DOI: 10.1002/cncy.21414

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      When evaluating upper tract urothelial specimens using UroVysion fluorescence in situ hybridization, only hypertetrasomic results (≥ 5 signals) should be interpreted as positive. Samples should be interpreted with caution in patients with a history of bladder carcinoma.

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      Usefulness of GATA3 and p40 immunostains in the diagnosis of metastatic urothelial carcinoma in cytology specimens (pages 468–473)

      Tamar C. Brandler, Mohamed S. Aziz, Lisa M. Rosen, Tawfiqul A. Bhuiya and Oksana Yaskiv

      Version of Record online: 7 APR 2014 | DOI: 10.1002/cncy.21424

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      GATA-binding protein 3 (GATA3) is useful in confirming the diagnosis of metastatic urothelial carcinoma (MUC) in cytology specimens and in distinguishing between MUC and squamous cell carcinoma. p40 is a valuable adjunct to GATA3 in the diagnosis of MUC in cytology specimens.

  6. Correspondence

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Clinician's Corner
    5. Review Article
    6. Original Articles
    7. Correspondence
    1. You have free access to this content
    2. You have free access to this content
      Reply to verification bias in diagnostic accuracy studies for fine-needle aspiration cytology (pages 474–475)

      Arivarasan Karunamurthy, Guoping Cai, Sanja Dacic, Walid E. Khalbuss, Liron Pantanowitz and Sara E. Monaco

      Version of Record online: 18 APR 2014 | DOI: 10.1002/cncy.21432

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