Cancer Cytopathology

Cover image for Vol. 122 Issue 7

July 2014

Volume 122, Issue 7

Pages 477–556

  1. CytoSource

    1. Top of page
    2. CytoSource
    3. Cytopathology Help Desk
    4. Editorial
    5. Review Articles
    6. Original Articles
    7. Correspondence
    8. Errata
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  2. Cytopathology Help Desk

    1. Top of page
    2. CytoSource
    3. Cytopathology Help Desk
    4. Editorial
    5. Review Articles
    6. Original Articles
    7. Correspondence
    8. Errata
  3. Editorial

    1. Top of page
    2. CytoSource
    3. Cytopathology Help Desk
    4. Editorial
    5. Review Articles
    6. Original Articles
    7. Correspondence
    8. Errata
    1. You have free access to this content
      Should the thyroid AUS/FLUS category be further stratified by malignancy risk? (pages 481–483)

      Michiya Nishino and Helen H. Wang

      Article first published online: 13 MAR 2014 | DOI: 10.1002/cncy.21412

      Is it time for subcategories within the atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) category in the Bethesda System for Reporting Thyroid Cytopathology? This editorial summarizes recent reports on risk stratification within the AUS/FLUS subcategory and its implications for patient management.

  4. Review Articles

    1. Top of page
    2. CytoSource
    3. Cytopathology Help Desk
    4. Editorial
    5. Review Articles
    6. Original Articles
    7. Correspondence
    8. Errata
    1. Aggressive variants of follicular cell-derived thyroid carcinomas: A cytopathologist's perspective (pages 484–503)

      Ricardo R. Lastra, Virginia A. LiVolsi and Zubair W. Baloch

      Article first published online: 24 MAR 2014 | DOI: 10.1002/cncy.21417

      Fine-needle aspiration is the dominant modality for diagnosing thyroid nodules. It has been demonstrated that certain follicular cell-derived thyroid carcinomas have a worse prognosis, and these are termed “aggressive variants” of thyroid carcinomas. The salient cytomorphologic features of these “aggressive variants” are described in this review.

    2. Growing indication for FNA to study and analyze tumor heterogeneity at metastatic sites (pages 504–511)

      Francisco Beca and Fernando Schmitt

      Article first published online: 29 JAN 2014 | DOI: 10.1002/cncy.21395

      Metastatic disease is a challenging clinical problem, and due to the increased recognition of cancer phenotypical heterogeneity and evolution, more frequent biopsies may be needed. Presently, because most ancillary studies and molecular techniques can be performed in cytological specimens, cytopathology can become a discipline with a central role in state-of-the-art diagnoses and treatment of metastatic disease.

  5. Original Articles

    1. Top of page
    2. CytoSource
    3. Cytopathology Help Desk
    4. Editorial
    5. Review Articles
    6. Original Articles
    7. Correspondence
    8. Errata
    1. You have free access to this content
      Thyroid “Atypia of undetermined significance” with nuclear atypia has high rates of malignancy and BRAF mutation (pages 512–520)

      Hyo Jin Park, Jae Hoon Moon, Cha Kyong Yom, Kyu Hyung Kim, June Young Choi, Sang Il Choi, Soon-Hyun Ahn, Woo-Jin Jeong, Won Woo Lee and So Yeon Park

      Article first published online: 11 MAR 2014 | DOI: 10.1002/cncy.21411

      The atypia of undetermined significance (AUS) with nuclear atypia subcategory of the Bethesda System for Reporting Thyroid Cytopathology was associated with the highest risk of malignancy and the greatest frequency of BRAF V600E mutation. The subcategorization of AUS by cytomorphology and BRAF V600E mutation status is important for predicting the risk of malignancy.

    2. Measurement of fine-needle aspiration thyroglobulin levels increases the detection of metastatic papillary thyroid carcinoma in cystic neck lesions (pages 521–526)

      Brittany J. Holmes, Lori J. Sokoll and Qing Kay Li

      Article first published online: 3 MAR 2014 | DOI: 10.1002/cncy.21413

      Measurement of thyroglobulin in fine-needle aspiration material from cystic neck masses improves the detection of metastatic papillary thyroid carcinoma. This ancillary test is particularly useful in cases with inadequate or nondiagnostic cytologic findings.

    3. Analysis of immunocytochemical and molecular BRAF expression in thyroid carcinomas: A cytohistologic institutional experience (pages 527–535)

      Esther Diana Rossi, Maurizio Martini, Sara Capodimonti, Tonia Cenci, Patrizia Straccia, Basilio Angrisani, Costantino Ricci, Paola Lanza, Celestino Pio Lombardi, Alfredo Pontecorvi, Luigi Maria Larocca and Guido Fadda

      Article first published online: 17 MAR 2014 | DOI: 10.1002/cncy.21416

      BRAF mutation is a strong indicator of papillary thyroid cancer because of its high specificity and positive predictive value, and it can easily be evaluated on thyroid cytologic samples. The new VE1 immunomarker—a monoclonal antibody directed against the mutated BRAF V600E protein—may be a valid alternative to DNA-based methods and produces good results in the presence of moderate and/or strong expression.

    4. Risk stratification in follicular neoplasm: A cytological assessment using the modified bethesda classification (pages 536–545)

      Berrin Ustun, David Chhieng, Alison Van Dyke, Tobias Carling, Elizabeth Holt, Robert Udelsman and Adebowale J. Adeniran

      Article first published online: 18 APR 2014 | DOI: 10.1002/cncy.21425

      The results of the current study indicate that follicular lesions with even subtle nuclear atypia have high positive predictive value for malignancy and therefore should be distinguished from other follicular lesions because these cases require more aggressive surgical management. The study also raises an important issue concerning the current thyroid classification based on the 2007 Bethesda classification of thyroid cytology. Future thyroid fine-needle aspiration classification schemes should consider subclassifying follicular neoplasms for the purpose of risk stratification.

    5. Focus on technology: How important is resolution in telecytopathology? (pages 546–552)

      Rachel Q. McMahon, Erin E. McCarthy, Scott J. Hetzel, Kasturi Das and Jimmie Stewart III

      Article first published online: 27 MAR 2014 | DOI: 10.1002/cncy.21404

      Two telepathology systems with differing resolutions are analyzed to determine whether there is a statistical difference in pathologists' ability to give preliminary diagnoses on fine-needle aspiration cases. Evaluation of the data indicates no statistical difference between the 2 systems, but the system with a higher resolution lends itself to greater user satisfaction.

  6. Correspondence

    1. Top of page
    2. CytoSource
    3. Cytopathology Help Desk
    4. Editorial
    5. Review Articles
    6. Original Articles
    7. Correspondence
    8. Errata
  7. Errata

    1. Top of page
    2. CytoSource
    3. Cytopathology Help Desk
    4. Editorial
    5. Review Articles
    6. Original Articles
    7. Correspondence
    8. Errata
    1. You have free access to this content
    2. You have free access to this content

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