Cancer Cytopathology

Cover image for Vol. 122 Issue 8

August 2014

Volume 122, Issue 8

Pages 557–634

  1. CytoSource

    1. Top of page
    2. CytoSource
    3. Clinician's Corner
    4. Review Article
    5. Original Articles
    1. You have free access to this content
  2. Clinician's Corner

    1. Top of page
    2. CytoSource
    3. Clinician's Corner
    4. Review Article
    5. Original Articles
  3. Review Article

    1. Top of page
    2. CytoSource
    3. Clinician's Corner
    4. Review Article
    5. Original Articles
    1. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): An overview and update for the cytopathologist (pages 561–576)

      Paul A. VanderLaan, Helen H. Wang, Adnan Majid and Erik Folch

      Article first published online: 23 APR 2014 | DOI: 10.1002/cncy.21431

      Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) allows access to mediastinal, hilar, and parenchymal lung tissue in a safe and minimally invasive fashion, frequently in an outpatient setting. The cytologic materials obtained by EBUS-TBNA have proven excellent for the diagnosis of lung cancer and for ancillary testing in lung cancer.

  4. Original Articles

    1. Top of page
    2. CytoSource
    3. Clinician's Corner
    4. Review Article
    5. Original Articles
    1. Accuracy of bronchial brush and wash specimens prepared by the ThinPrep method in the diagnosis of pulmonary small cell carcinoma (pages 577–585)

      Cheng Wang, Qiuli Duan, Margaret Kelly and Máire A. Duggan

      Article first published online: 13 MAY 2014 | DOI: 10.1002/cncy.21435

      In the diagnosis of pulmonary small cell carcinoma, unsatisfactory brush and wash Thinprep specimens are infrequent. Both have moderate sensitivity and high specificity, positive predictive value, and negative predictive value; abnormal cell features resemble those seen in conventional preparations.

    2. Wilms tumor 1/cytokeratin dual-color immunostaining reveals distinctive staining patterns in metastatic melanoma, metastatic carcinoma, and mesothelial cells in pleural fluids: An effective first-line test for the workup of malignant effusions (pages 586–595)

      James R. Conner, Edmund S. Cibas, Jason L. Hornick and Xiaohua Qian

      Article first published online: 17 JUL 2014 | DOI: 10.1002/cncy.21439

      Simple Wilms tumor 1 (WT1)/AE1/AE3 dual-color double immunohistochemical staining reveals 4 distinct staining patterns in various epithelioid malignant effusions, which can be used as a rapid and cost-effective first-line test for detecting the presence and determining the site of origin of metastases in malignant effusions.

    3. CD117: A novel ancillary marker for papillary thyroid carcinoma in fine-needle aspiration biopsies (pages 596–603)

      Marc P. Pusztaszeri, Peter M. Sadow and William C. Faquin

      Article first published online: 11 JUN 2014 | DOI: 10.1002/cncy.21437

      To investigate previous reports of CD117 down-regulation in papillary thyroid carcinoma (PTC), CD117 expression is assessed in cytologic and corresponding histologic samples of PTC (n = 35) compared with a control group of benign thyroid nodules (n = 30). CD117 is expressed by benign thyroid nodules and non-neoplastic follicular epithelium but is absent or nearly absent in PTC, suggesting that CD117 may be useful as an ancillary marker in the evaluation of PTC in thyroid fine-needle aspiration biopsy.

    4. What is the malignancy risk for atypia of undetermined significance? Three years' experience at a university hospital in Turkey (pages 604–610)

      Pinar Uyar Gocun, Esra Karakus, Pinar Bulutay, Mujde Akturk, Murat Akin and Aylar Poyraz

      Article first published online: 28 MAY 2014 | DOI: 10.1002/cncy.21434

      A multimodal approach (clinical, radiologic, and cytopathologic) is very important in the management of thyroid nodules diagnosed as atypia of undetermined significance (AUS)/follicular lesion of undetermined significance. Therefore, recommendation for repeat fine-needle aspiration following an initial diagnosis of AUS should be based on a multimodal approach for each particular patient.

    5. The value of second opinion in thyroid cytology: A review (pages 611–619)

      Rene Gerhard and Scott L. Boerner

      Article first published online: 28 MAY 2014 | DOI: 10.1002/cncy.21436

      Second opinion review of thyroid fine-needle aspiration improves diagnostic accuracy and is better supported by clinical follow-up. Changes in the clinical management occur in a significant number of patients with thyroid nodules after the results of second-opinion diagnoses.

    6. Papanicolaou tests with coexisting squamous and glandular abnormalities (pages 620–626)

      Li Yan Khor, Fadi W. Abdul-Karim, Amanda E. Bruening, Dana K. Weber Noffsinger and Christine N. Booth

      Article first published online: 17 JUN 2014 | DOI: 10.1002/cncy.21448

      Dual Papanicolaou test interpretations with both squamous and glandular atypia were more often associated with squamous lesions on follow-up. Dual interpretations were associated with 9 coexisting squamous and glandular lesions on follow-up.

    7. You have free access to this content
      Targeted multiprobe fluorescence in situ hybridization analysis for elucidation of inconclusive pancreatobiliary cytology (pages 627–634)

      Tatjana Vlajnic, Gina Somaini, Spasenija Savic, Audrey Barascud, Bruno Grilli, Michelle Herzog, Ellen C. Obermann, Brittany J. Holmes, Syed Z. Ali, Lukas Degen and Lukas Bubendorf

      Article first published online: 18 APR 2014 | DOI: 10.1002/cncy.21429

      This study shows that multitarget fluorescence in situ hybridization (FISH) is diagnostically helpful in cases of inconclusive pancreatobiliary cytology (including atypical and suspicious categories).

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