Cancer Cytopathology

Cover image for Vol. 122 Issue 9

September 2014

Volume 122, Issue 9

Pages 635–710

  1. CytoSource

    1. Top of page
    2. CytoSource
    3. Cytopathology Help Desk
    4. Review Article
    5. Original Articles
    1. You have free access to this content
  2. Cytopathology Help Desk

    1. Top of page
    2. CytoSource
    3. Cytopathology Help Desk
    4. Review Article
    5. Original Articles
  3. Review Article

    1. Top of page
    2. CytoSource
    3. Cytopathology Help Desk
    4. Review Article
    5. Original Articles
    1. Nucleic acid-based assays for the detection of high-risk human papillomavirus: A technical review (pages 639–645)

      Jane S. Gibson

      Article first published online: 17 JUN 2014 | DOI: 10.1002/cncy.21451

      Nucleic acid-based high-risk human papillomavirus testing is essential to contemporary cervical cancer screening. An understanding of methodologies associated with human papillomavirus testing is important to the practice of laboratory medicine.

  4. Original Articles

    1. Top of page
    2. CytoSource
    3. Cytopathology Help Desk
    4. Review Article
    5. Original Articles
    1. Evaluation of intraoperative cytological assessment of bone resection margins in patients with oral squamous cell carcinoma (pages 646–656)

      Markus Nieberler, Patrick Häusler, Enken Drecoll, Mechthild Stoeckelhuber, Herbert Deppe, Frank Hölzle, Andreas Kolk, Klaus-Dietrich Wolff, Marco Rainer Kesting and Gregor Weirich

      Article first published online: 18 APR 2014 | DOI: 10.1002/cncy.21428

      The current study evaluates the intraoperative cytological assessment of bone resection margins to control resection status in patients with bone-infiltrating oral squamous cell carcinomas. The work demonstrates that intraoperative cytological assessment of bone resection margins could supplement the intraoperative assessment of soft tissue margins through the immediate microscopic control of bony resection margins, enabling a guided reresection of positive bone margins during a surgical intervention to optimize surgical concepts, especially for patients with carcinoma, who receive primary reconstruction with osteo-(myo-)cutaneous microvascular transplants.

    2. A minimum fluid volume of 75 mL is needed to ensure adequacy in a pleural effusion: A retrospective analysis of 2540 cases (pages 657–665)

      Lisa M. Rooper, Syed Z. Ali and Matthew T. Olson

      Article first published online: 24 JUL 2014 | DOI: 10.1002/cncy.21452

      A pleural effusion volume of ≥ 75 mL is required to eliminate the influence of specimen size on diagnostic adequacy. Above 75 mL, larger volumes further decrease the number of indeterminate or nondiagnostic results.

    3. You have free access to this content
      FNAB of benign thyroid nodules with papillary hyperplasia: A cytological and histological evaluation (pages 666–677)

      Marc P. Pusztaszeri, Jeffrey F. Krane, Edmund S. Cibas, Gilbert Daniels and William C. Faquin

      Article first published online: 2 JUN 2014 | DOI: 10.1002/cncy.21441

      A subset of benign thyroid nodules with papillary hyperplasia is misinterpreted on fine-needle aspiration biopsy as “suspicious for malignancy” or as “malignant,” potentially resulting in unnecessary surgery. These cases are characterized histologically by a high proportion of papillary hyperplasia and cytologically by papillary structures, variable nuclear atypia, small nuclear size, and cytoplasmic pigment.

    4. Cytologic features of parathyroid fine-needle aspiration on ThinPrep preparations (pages 678–684)

      Shelley I. Odronic, Jordan P. Reynolds and Deborah J. Chute

      Article first published online: 18 JUN 2014 | DOI: 10.1002/cncy.21453

      The cytologic features of parathyroid tissue on ThinPrep slides differ from those found on smears. ThinPrep cases demonstrate lower cellularity, lack papillary architecture, and show a predominant microfollicular pattern compared with aspirate smears.

    5. Programmed cell death 4 and microRNA 21 inverse expression is maintained in cells and exosomes from ovarian serous carcinoma effusions (pages 685–693)

      Rocco Cappellesso, Andrea Tinazzi, Thomas Giurici, Francesca Simonato, Vincenza Guzzardo, Laura Ventura, Marika Crescenzi, Silvia Chiarelli and Ambrogio Fassina

      Article first published online: 28 MAY 2014 | DOI: 10.1002/cncy.21442

      PDCD4 and miR-21 are involved in ovarian serous carcinoma oncogenesis. The transfer of miR-21 by exosomes could promote oncogenic transformation in target cells distant from the primary tumor without direct colonization by cancer cells and could be used as diagnostic tool.

    6. Factors associated with reduced accuracy in Papanicolaou tests for patients with invasive cervical cancer (pages 694–701)

      Lichao Zhao, Nicolas Wentzensen, Roy R. Zhang, S. Terence Dunn, Michael A. Gold, Sophia S. Wang, Mark Schiffman, Joan L. Walker and Rosemary E. Zuna

      Article first published online: 28 MAY 2014 | DOI: 10.1002/cncy.21443

      Papanicolaou tests from women with invasive cervical cancer, particularly squamous cancers, have a higher rate of unsatisfactory and limited-quality samples. Human papillomavirus testing of unsatisfactory ThinPrep Pap tests in women aged > 30 years can identify high-risk women in this scenario.

    7. Human papillomavirus testing in young women: Clinical outcomes of human papillomavirus triage in a UK cervical screening program (pages 702–710)

      Michael McKenna and Mary M. McMenamin

      Article first published online: 2 JUN 2014 | DOI: 10.1002/cncy.21444

      Colposcopy referrals increased significantly with the introduction of human papillomavirus triage. In women with borderline cytology or mild dyskaryosis who tested positive for human papillomavirus, there was no significant difference noted in the rate of biopsy-confirmed cases of cervical intraepithelial neoplasia of type 2 or higher or type 3 or higher between women aged < 25 years and those aged ≥ 25 years.

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