Cancer Cytopathology

Cover image for Vol. 123 Issue 4

April 2015

Volume 123, Issue 4

Pages i–iv, 203–266

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Cytopathology Help Desk
    5. Commentary
    6. Original Articles
    1. You have free access to this content
      Issue information (pages i–iv)

      Article first published online: 14 APR 2015 | DOI: 10.1002/cncy.21547

  2. CytoSource

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Cytopathology Help Desk
    5. Commentary
    6. Original Articles
    1. You have free access to this content
  3. Cytopathology Help Desk

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Cytopathology Help Desk
    5. Commentary
    6. Original Articles
  4. Commentary

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Cytopathology Help Desk
    5. Commentary
    6. Original Articles
    1. You have free access to this content
      Thyroid FNA: International perspectives from the European Congress of Cytopathology—Can we cross the bridge of classifications? (pages 207–211)

      Esther Diana Rossi, Marc Pusztaszeri, Fernando Schmitt, Massimo Bongiovanni, Ashish Chandra and William C. Faquin

      Article first published online: 14 JAN 2015 | DOI: 10.1002/cncy.21517

      The 38th European Congress of Cytology 2014, held in Geneva, Switzerland, offered a specific symposium concerning the Bethesda thyroid classification scheme. What emerged in that thyroid symposium, which was attended by all of the authors of this commentary, was the persistent need for a universally adopted thyroid fine-needle aspiration reporting system that can diagnose the same thyroid nodule in the same way anywhere in the world. Herein, the authors critically outline the advantages and limits of thyroid fine-needle aspiration classification schemes that were discussed at the symposium.

  5. Original Articles

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Cytopathology Help Desk
    5. Commentary
    6. Original Articles
    1. Interpretation of p16INK4a/Ki-67 dual immunostaining for the triage of human papillomavirus-positive women by experts and nonexperts in cervical cytology (pages 212–218)

      Elena Allia, Guglielmo Ronco, Anna Coccia, Patrizia Luparia, Luigia Macrì, Corinna Fiorito, Francesca Maletta, Cristina Deambrogio, Sara Tunesi, Laura De Marco, Anna Gillio-Tos, Anna Sapino and Bruno Ghiringhello

      Article first published online: 22 DEC 2014 | DOI: 10.1002/cncy.21511

      In the current study, p16INK4a/Ki-67 immunostaining demonstrated good reproducibility and specificity when triaging women who were positive for the human papillomavirus. Dual-staining interpretation can be performed, after brief training, even by staff who are not experts in the morphological interpretation of cytology.

    2. You have free access to this content
      Combination of p16INK4a/Ki67 immunocytology and hpv polymerase chain reaction for the noninvasive analysis of HPV involvement in head and neck cancer (pages 219–229)

      Maximilian Linxweiler, Florian Bochen, Silke Wemmert, Cornelia Lerner, Andrea Hasenfus, Rainer Maria Bohle, Basel Al-Kadah, Zoltan Ferenc Takacs, Sigrun Smola and Bernhard Schick

      Article first published online: 29 DEC 2014 | DOI: 10.1002/cncy.21512

      Simultaneous immunocytochemical detection of p16INK4a and Ki67 was performed on liquid-based cytological smears from 45 head and neck cancer patients and 20 control patients, and the same cytological material was used for the detection of HPV DNA by specific PCR. Combining both techniques, we could reliably discriminate between latent and carcinogenic HPV infections as well as HPV-negative cases and thus provide information on the prognosis of HNSCC patients and facilitate therapeutic decisions.

    3. You have full text access to this OnlineOpen article
      Assessment of EGFR and KRAS mutation status from FNAs and core-needle biopsies of non-small cell lung cancer (pages 230–236)

      Maria D. Lozano, Tania Labiano, Jose Echeveste, Alfonso Gurpide, Salvador Martín-Algarra, Guili Zhang, Abha Sharma and John F. Palma

      Article first published online: 19 DEC 2014 | DOI: 10.1002/cncy.21513

      EGFR or KRAS mutation status can be successfully determined in Papanicolaou-stained fine-needle aspiration samples and hematoxylin and eosin-stained core-needle biopsy samples using polymerase chain reaction-based tests. The findings from this pilot study highlight the feasibility of rapid and accurate mutation testing for patient samples derived from minimally invasive diagnostic procedures or from samples with limited available tissue.

    4. Reducing indeterminate thyroid FNAs (pages 237–243)

      Andrew A. Renshaw and Edwin W. Gould

      Article first published online: 20 JAN 2015 | DOI: 10.1002/cncy.21520

      Modifying the Bethesda criteria can decrease the rate of indeterminate thyroid fine-needle aspiration diagnoses without a significant decrease in the risk of malignancy. Cytologists may find the data and methods described in this report useful for better defining the indeterminate rate in their own laboratories.

    5. Strategies for improving diagnostic accuracy of biliary strictures (pages 244–252)

      Marcela Salomao, Tamas A. Gonda, Elizabeth Margolskee, Vasco Eguia, Helen Remotti, John M. Poneros, Amrita Sethi and Anjali Saqi

      Article first published online: 6 JAN 2015 | DOI: 10.1002/cncy.21509

      Key cytological features for discriminating between nonneoplastic and neoplastic biliary brushings are described. Also, the article identifies sampling methods (cytology, biopsy, and/or FISH) that improve the diagnostic yield of pancreatobiliary tumors.

    6. ARID1A is a useful marker of malignancy in peritoneal washings for endometrial carcinoma (pages 253–257)

      Zoltan Nagymanyoki, George L. Mutter, Jason L. Hornick and Edmund S. Cibas

      Article first published online: 29 DEC 2014 | DOI: 10.1002/cncy.21514

      ARID1A (AT-rich interactive domain 1A gene) is a newly identified tumor suppressor gene in endometrioid carcinomas. This article discusses the potential use of ARID1A immunohistochemistry to identify malignant endometrial cells in peritoneal washings.

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