Cancer Cytopathology

Cover image for Vol. 123 Issue 5

May 2015

Volume 123, Issue 5

Pages 267–326

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Clinician's Corner
    5. Commentary
    6. Original Articles
    1. You have free access to this content
      Issue information (pages i–iii)

      Article first published online: 18 MAY 2015 | DOI: 10.1002/cncy.21567

  2. CytoSource

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Clinician's Corner
    5. Commentary
    6. Original Articles
    1. You have free access to this content
  3. Clinician's Corner

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Clinician's Corner
    5. Commentary
    6. Original Articles
  4. Commentary

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Clinician's Corner
    5. Commentary
    6. Original Articles
    1. You have free access to this content
      The Pap test and Bethesda 2014 (pages 271–281)

      Ritu Nayar and David C. Wilbur

      Article first published online: 1 MAY 2015 | DOI: 10.1002/cncy.21521

      The history of “The Bethesda System” for reporting cervical cytology goes back almost 3 decades. This terminology and the process that created it have had a profound impact on the practice of cervical cytology for laboratorians and clinicians alike. Herein, we summarize the process and rationale by which updates were made to the terminology in 2014 and outline the contents of the new, third edition of the Bethesda atlas and corresponding website.

  5. Original Articles

    1. Top of page
    2. Issue Information
    3. CytoSource
    4. Clinician's Corner
    5. Commentary
    6. Original Articles
    1. You have full text access to this OnlineOpen article
      Comparison of cervical cancer screening results among 256,648 women in multiple clinical practices (pages 282–288)

      Amy J. Blatt, Ronald Kennedy, Ronald D. Luff, R. Marshall Austin and Douglas S. Rabin

      Article first published online: 10 APR 2015 | DOI: 10.1002/cncy.21544

      Cervical cancer screening using a cotest that includes both a human papillomavirus test and a Papanicolaou test, compared with human papillomavirus-only testing, is better for identifying cervical intraepithelial neoplasia 3 or more severe cervical biopsy results. The current results support cotesting for women ages 30 to 65 years as the most effective screening test for cervical cancer detection.

    2. Comprehensive mutation profiling by next-generation sequencing of effusion fluids from patients with high-grade serous ovarian carcinoma (pages 289–297)

      Ronak H. Shah, Sasinya N. Scott, A. Rose Brannon, Douglas A. Levine, Oscar Lin and Michael F. Berger

      Article first published online: 5 FEB 2015 | DOI: 10.1002/cncy.21522

      Cytology specimens represent suitable material for high-throughput sequencing. In this study, all mutations described by The Cancer Genome Atlas are independently identified in samples of effusion fluid.

    3. HNF1β and S100A1 are useful biomarkers for distinguishing renal oncocytoma and chromophobe renal cell carcinoma in FNA and core needle biopsies (pages 298–305)

      James R. Conner, Michelle S. Hirsch and Vickie Y. Jo

      Article first published online: 4 MAR 2015 | DOI: 10.1002/cncy.21530

      The distinction between renal oncocytoma and chromophobe renal cell carcinoma can be challenging, especially in fine-needle aspiration and core biopsies. Immunoreactivity for both HNF1β and S100A1 is present in a significantly greater proportion of oncocytomas than in chromophobe renal cell carcinomas, and these immunohistochemical markers may aid in the differential diagnosis.

    4. Cytopathology of pulmonary adenocarcinoma with a single histological pattern using the proposed International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification (pages 306–317)

      Erika F. Rodriguez, Sanja Dacic, Liron Pantanowitz, Walid E. Khalbuss and Sara E. Monaco

      Article first published online: 18 MAR 2015 | DOI: 10.1002/cncy.21532

      The current study investigates the cytological features of lung adenocarcinoma subtypes proposed by the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) from cases with histology showing a single pattern. The findings demonstrate that some architectural and nuclear features may be helpful in distinguishing the prognostically adverse solid pattern from other patterns.

    5. FNA, core biopsy, or both for the diagnosis of lung carcinoma: Obtaining sufficient tissue for a specific diagnosis and molecular testing (pages 318–326)

      Shana M. Coley, John P. Crapanzano and Anjali Saqi

      Article first published online: 24 FEB 2015 | DOI: 10.1002/cncy.21527

      Lung lesions are frequently sampled under computed tomography guidance. Fine-needle aspiration, core biopsy, and both are equivalent at providing tissue for histological, immunohistochemical, and molecular diagnoses.

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