Prospective evaluation of p16/Ki-67 dual-stained cytology for managing women with abnormal Papanicolaou cytology: PALMS study results (pages 373–381)
Christine Bergeron, Hans Ikenberg, Mario Sideri, Karin Denton, Johannes Bogers, Dietmar Schmidt, Francisco Alameda, Thomas Keller, Susanne Rehm, Ruediger Ridder and for the PALMS Study Group
Article first published online: 17 APR 2015 | DOI: 10.1002/cncy.21542
Women with Papanicolaou cytology results of atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion can be efficiently triaged using p16/Ki-67 dual-stained cytology. The results of this current large, prospective, pan-European screening trial (Primary ASC-US LSIL Marker Study [PALMS]) confirm the high positivity of dual-stained cytology for disease prediction, which may reduce the number of unnecessary colposcopy referrals.