Article

Expression of synapsin III in nerve terminals and neurogenic regions of the adult brain

  1. Vincent A. Pieribone1,2,*,
  2. Barbara Porton2,
  3. Beatrice Rendon2,
  4. Jian Feng3,
  5. Paul Greengard2,
  6. Hung-Teh Kao2,4

Article first published online: 31 OCT 2002

DOI: 10.1002/cne.10417

Issue

The Journal of Comparative Neurology

The Journal of Comparative Neurology

Volume 454, Issue 2, pages 105–114, 9 December 2002

Additional Information

How to Cite

Pieribone, V. A., Porton, B., Rendon, B., Feng, J., Greengard, P. and Kao, H.-T. (2002), Expression of synapsin III in nerve terminals and neurogenic regions of the adult brain. J. Comp. Neurol., 454: 105–114. doi: 10.1002/cne.10417

Author Information

  1. 1

    The John B. Pierce Laboratory, Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510

  2. 2

    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021

  3. 3

    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214

  4. 4

    Department of Psychiatry, New York University Medical College, New York, New York 10016

*The John B. Pierce Laboratory, Yale University School of Medicine, 290 Congress Avenue, New Haven, CT 06519

Publication History

  1. Issue published online: 31 OCT 2002
  2. Article first published online: 31 OCT 2002
  3. Manuscript Accepted: 19 JUL 2002
  4. Manuscript Revised: 26 JUN 2002
  5. Manuscript Received: 10 JAN 2002

Funded by

  • US Public Health Service. Grant Numbers: MH39327, AG15072, R29 NS35941

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Keywords:

  • neurogenesis;
  • PSA-NCAM;
  • immunocytochemistry;
  • soma

Abstract

We have examined the distribution of synapsin III in the adult mouse brain. Expression of synapsin III was observed in puncta throughout the brain, but demonstrated greater regional variation than that of synapsins I or II. This punctate staining is typical for synaptic vesicle proteins located at nerve terminals. These findings are also consistent with the well-established role for synapsins in regulating neurotransmitter release. However, unexpectedly, synapsin III was also highly expressed in the cell body and processes of immature neurons in neurogenic regions of the adult brain, such as the hippocampal dentate gyrus, rostral migratory stream, and olfactory bulb. Many synapsin III-positive neurons also reacted with an antibody directed toward polysialylated-neuronal cell adhesion molecule, a marker of immature, migrating neurons. These results suggest that synapsin III may also play a role in adult neurogenesis. J. Comp. Neurol. 454:105–114, 2002. © 2002 Wiley-Liss, Inc.

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