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Macaque monkey retrosplenial cortex: II. Cortical afferents

Authors

  • Yasushi Kobayashi,

    1. Department of Psychiatry, Center for Neuroscience, California National Primate Research Center, and the M.I.N.D. Institute. University of California, Davis, Davis, California 95616
    2. Department of Anatomy, Kyorin University School of Medicine, Tokyo 181-8611, Japan
    Current affiliation:
    1. Department of Anatomy, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan
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  • David G. Amaral

    Corresponding author
    1. Department of Psychiatry, Center for Neuroscience, California National Primate Research Center, and the M.I.N.D. Institute. University of California, Davis, Davis, California 95616
    • Center for Neuroscience, University of California, Davis, 1544 Newton Court, Davis, CA 95616
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Abstract

We investigated the cortical afferents of the retrosplenial cortex and the adjacent posterior cingulate cortex (area 23) in the macaque monkey by using the retrograde tracers Fast blue and Diamidino yellow. We quantitatively analyzed the distribution of labeled neurons throughout the cortical mantle. Injections involving the retrosplenial cortex resulted in labeled neurons within the retrosplenial cortex and in areas 23 and 31 (∼78% of the total labeled cells). In the remainder of the cortex, the heaviest projections originated in the hippocampal formation, including the entorhinal cortex, subiculum, presubiculum, and parasubiculum. The parahippocampal and perirhinal cortices also contained many labeled neurons, as did the prefrontal cortex, mainly in areas 46, 9, 10, and 11, and the occipital cortex, mainly area V2. Injections in area 23 also resulted in numerous labeled cells in the posterior cingulate and retrosplenial regions (∼67% of total labeled cells). As in the retrosplenial cortex, injections of area 23 led to many labeled neurons in the frontal cortex, although most of these cells were in areas 9 and 46. Larger numbers of retrogradely labeled cells were also distributed more widely in the posterior parietal cortex, including areas 7a, 7m, LIP, and DP. There were some labeled cells in the parahippocampal cortex. These connections are consistent with the retrosplenial cortex acting as an interface between the working memory functions in the prefrontal areas and the long-term memory encoding in the medial temporal lobe. The posterior cingulate cortex, in contrast, may be more highly associated with visuospatial functions. J. Comp. Neurol. 466:48–79, 2003. © 2003 Wiley-Liss, Inc.

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