Forebrain connectivity of the prefrontal cortex in the marmoset monkey (Callithrix jacchus): An anterograde and retrograde tract-tracing study

Authors

  • Angela C. Roberts,

    Corresponding author
    1. Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK
    2. Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3DY, UK
    • Department of Physiology, Development and Neuroscience, University of Cambridge, Downing St., Cambridge, CB2 3DY, UK
    Search for more papers by this author
  • Davorka L. Tomic,

    1. Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3DY, UK
    Search for more papers by this author
  • Caroline H. Parkinson,

    1. Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, UK
    Search for more papers by this author
  • Tom A. Roeling,

    1. Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, UK
    Current affiliation:
    1. Rudolf Magnus Institute of Neuroscience, Dept. of Pharmacology and Anatomy, University Medical Centre, Utrecht, The Netherlands
    Search for more papers by this author
  • David J. Cutter,

    1. Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3DY, UK
    Search for more papers by this author
  • Trevor W. Robbins,

    1. Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK
    2. Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, UK
    Search for more papers by this author
  • Barry J. Everitt

    1. Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK
    2. Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, UK
    Search for more papers by this author

Abstract

The cortical and subcortical forebrain connections of the marmoset prefrontal cortex (PFC) were examined by injecting the retrograde tracer, choleratoxin, and the anterograde tracer, biotin dextran amine, into four sites within the PFC. Two of the sites, the lateral and orbital regions, had previously been shown to provide functionally dissociable contributions to distinct forms of behavioral flexibility, attentional set-shifting and discrimination reversal learning, respectively. The dysgranular and agranular regions lying on the orbital and medial surfaces of the frontal lobes were most closely connected with limbic structures including cingulate cortex, amygdala, parahippocampal cortex, subiculum, hippocampus, hypothalamus, medial caudate nucleus, and nucleus accumbens as well as the magnocellular division of the mediodorsal nucleus of the thalamus and midline thalamic nuclei, consistent with findings in the rhesus monkey. In contrast, the granular region on the dorsal surface closely resembled area 8Ad in macaques and had connections restricted to posterior parietal cortex primarily associated with visuospatial functions. However, it also had connections with limbic cortex, including retrosplenial and caudal cingulate cortex as well as auditory processing regions in the superior temporal cortex. The granular region on the lateral convexity had the most extensive connections. Based on its architectonics and functionality, it resembled areas 12/45 in macaques. It had connections with high-order visual processing regions in the inferotemporal cortex and posterior parietal cortex, higher-order auditory and polymodal processing regions in the superior temporal cortex. In addition it had extensive connections with limbic regions including the amygdala, parahippocampal cortex, cingulate, and retrosplenial cortex. J. Comp. Neurol. 502:86–112, 2007. © 2007 Wiley-Liss, Inc.

Ancillary