Atypical expression of Drosophila gustatory receptor genes in sensory and central neurons
Version of Record online: 7 DEC 2007
Copyright © 2007 Wiley-Liss, Inc.
Journal of Comparative Neurology
Volume 506, Issue 4, pages 548–568, 1 February 2008
How to Cite
Thorne, N. and Amrein, H. (2008), Atypical expression of Drosophila gustatory receptor genes in sensory and central neurons. J. Comp. Neurol., 506: 548–568. doi: 10.1002/cne.21547
- Issue online: 7 DEC 2007
- Version of Record online: 7 DEC 2007
- Manuscript Accepted: 1 OCT 2007
- Manuscript Revised: 2 AUG 2007
- Manuscript Received: 6 JUN 2007
- National Institutes of Health. Grant Number: RO1 GMDC05606-01
- gustatory receptor neurons
Members of the Drosophila gustatory receptor (Gr) gene family are generally expressed in chemosensory neurons and are known to mediate the perception of sugars, bitter substrates, CO2, and pheromones. The Gr gene family consists of 68 members, many of which are organized in gene clusters of up to six genes, yet only expression of about 15 Gr genes has been characterized in detail prior to this study. Here we describe the first comprehensive expression analysis of six highly conserved Gr genes, Gr28a and Gr28b.a to Gr28b.e. Four of these Gr genes are not only expressed in the characteristic pattern associated with previously analyzed Gr genes—chemosensory neurons of the gustatory and olfactory system—but several other types of sensory neurons and neurons in the brain. Specifically, we show that several of the Gr28 genes are expressed in abdominal multidendritic neurons, putative hygroreceptive neurons of the arista, neurons associated with the Johnston's organ, peripheral proprioceptive neurons in the legs, neurons in the larval and adult brain, and oenocytes. Thus, our findings suggest that some Gr genes are utilized in nongustatory roles in the nervous system and tissues involved in proprioception, hygroreception, and other sensory modalities. It is also possible that the Gr28 genes have chemosensory roles in the detection of internal ligands. J. Comp. Neurol. 506:548–568, 2008. © 2007 Wiley-Liss, Inc.