Expression of FOXP2 in the developing monkey forebrain: Comparison with the expression of the genes FOXP1, PBX3, and MEIS2

Authors

  • Kaoru Takahashi,

    1. Developmental Neurobiology Group, Mitsubishi Kagaku Institute of Life Sciences, Tokyo, Tokyo 194-8511, Japan
    2. Department of Immunopathology, Tokyo Medical and Dental University, Tokyo, Tokyo 113-8510, Japan
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  • Fu-Chin Liu,

    1. Institute of Neuroscience, National Yang-Ming University, Taipei 112, Taiwan, Republic of China
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  • Takao Oishi,

    1. Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, Inuyama, Aichi 484-8506, Japan
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  • Takuma Mori,

    1. Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, Inuyama, Aichi 484-8506, Japan
    Current affiliation:
    1. Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037
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  • Noriyuki Higo,

    1. Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305-8568, Japan
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  • Motoharu Hayashi,

    1. Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, Inuyama, Aichi 484-8506, Japan
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  • Katsuiku Hirokawa,

    1. Department of Immunopathology, Tokyo Medical and Dental University, Tokyo, Tokyo 113-8510, Japan
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  • Hiroshi Takahashi

    Corresponding author
    1. Developmental Neurobiology Group, Mitsubishi Kagaku Institute of Life Sciences, Tokyo, Tokyo 194-8511, Japan
    • Developmental Neurobiology Group, Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida-shi, 194-8511 Tokyo, Japan
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Abstract

By using the developing monkey brain as a model for human development, we investigated the expression pattern of the FOXP2 gene, a member of the FOX family of transcription factors in the developing monkey brain, and compared its expression pattern with transcription factors PBX3, MEIS2, and FOXP1. We observed FOXP2 mRNA expression in several brain structures, including the striatum, the islands of Calleja and other basal forebrain regions, the cerebral cortex, and the thalamus. FOXP2 mRNA was preferentially expressed in striosomal compartments during striatal development. The striosomal expression was transient and developmentally down-regulated in a topographical order. Specifically, during the perinatal state, striosomal FOXP2 expression was detected in both the caudate nucleus and the putamen, although expression was more prominent in the caudate nucleus than in the putamen. Striosomal FOXP2 expression declined during the postnatal period, first in the putamen and later in the caudate nucleus. During the same period, we also detected PBX3 mRNA in the striosomal compartment of the developing monkey striatum. FOXP2, as well as PBX3 and MEIS2, was expressed in the islands of Calleja and other cell clusters of the basal forebrain. FOXP2, in combination with PBX3 and MEIS2, may play a pivotal role in the development of striosomal neurons of the striatum and the islands of Calleja. J. Comp. Neurol. 509:180–189, 2008. © 2008 Wiley-Liss, Inc.

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