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CNE_22020_sm_SupplFig11.tif13389KSuppl.Fig. 11. Distribution of Epo-R in cortical and hippocampal areas during postnatal development and ageing. A-P: Pictures illustrate Epo-R detection in the neocortex, areas CA1 and CA3 and dentate gyrus of the hippocampus at 5D, 21D, 3M and 12M. Q: Phenotypic characterization of the round-shaped cells expressing high Epo-R immunofluorescent labeling in the stratum oriens of area CA1 at 5D. Epo-R (green) was detected in combination with NeuN (magenta). Some cells double-labeled with NeuN and Epo-R are indicated by white arrows. Stained microvessels are marked by asterisks. Abbreviations: D, day; DG, dentate gyrus; GCL, granule cell layer; h, hilus; M, month; NCx, neocortex; SO, stratum oriens; SP, stratum pyramidale; SR, stratum radiatum.
CNE_22020_sm_SupplFig12.tif16547KSuppl.Fig. 12. Dual immunofluorescent labelings of Epo-R (A, D) together with either the microglial marker Ox-42 (B) or the astroglial marker GFAP (E) in area CA1 at 12M. Epo-R is detected neither in microglia, nor in astrocytes, as demonstrated on merged images (C and F, respectively).
CNE_22020_sm_SupplFig13.tif26548KSuppl.Fig. 13. Dual immunolabelings of βc (green) and NeuN (magenta) in area CA1 and in the neocortex during postnatal development and ageing. Neurons expressing βc are indicated by white arrows. Abbreviations: D, day; NCx, neocortex; M, month.
CNE_22020_sm_SupplFig14.tif26087KSuppl.Fig. 14. Dual immunofluorescent labelings of βc (A, D) together with either the microglial marker Ox-42 (B) or the astroglial marker GFAP (E) in area CA1 at 12M. βc is not detected in microglia (merged image C). However, some astrocytes express βc above detection threshold, as illustrated on merged images at low and high magnifications (F and G, respectively). White arrowheads point out astrocytes expressing βc.
CNE_22020_sm_SupplFig15.tif15828KSuppl.Fig. 15. Immunolabeling of Epo in the hippocampus during postnatal development and ageing. (A) Epo detection in the dentate gyrus and in area CA1. (B) Enlarged view indicated by the white box in the stratum radiatum of area CA1 at 5D illustrating a dendritic process (see white arrow) double immunolabeled with Epo and NeuN (neuronal marker). Abbreviations: D, day; DG, dentate gyrus; GCL, granule cell layer; h, hilus; M, month; SO, stratum oriens; SP, stratum pyramidale; SR, stratum radiatum.
CNE_22020_sm_SupplFig16.tif17103KSuppl.Fig. 16. Dual immunofluorescent labelings of Epo (A, D) together with either the microglial marker Ox-42 (B) or the astroglial marker GFAP (E) in area CA1 at 12M. Epo is not detected in microglia (merged image C). However, scarce astrocytes express Epo above detection threshold as pointed out by the white arrowhead (merged image F).

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