The first two authors contributed equally.
Article
You have free access to this content
Leptin targets in the mouse brain
Article first published online: 23 FEB 2009
DOI: 10.1002/cne.22025
Copyright © 2009 Wiley-Liss, Inc.
Additional Information
How to Cite
Scott, M. M., Lachey, J. L., Sternson, S. M., Lee, C. E., Elias, C. F., Friedman, J. M. and Elmquist, J. K. (2009), Leptin targets in the mouse brain. J. Comp. Neurol., 514: 518–532. doi: 10.1002/cne.22025
Publication History
- Issue published online: 6 APR 2009
- Article first published online: 23 FEB 2009
- Accepted manuscript online: 23 FEB 2009 12:00AM EST
- Manuscript Accepted: 4 FEB 2009
- Manuscript Revised: 8 AUG 2008
- Manuscript Received: 15 JUN 2007
Funded by
- National Institutes of Heath. Grant Numbers: DK056116, MH061583, DK053301, DK062656
LITERATURE CITED
- , , , . 2000. Leptin regulation of neuroendocrine systems. Front Neuroendocrinol 21: 263–307.
- , . 2005. The gut and energy balance: visceral allies in the obesity wars. Science 307: 1909–1914.
- , , , , , , , , , , . 2004. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42: 983–991.
- , , , , , , , , , , , , 2003. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421: 856–859.
- , , , . 2004. Insulin and leptin as adiposity signals. Recent Prog Horm Res 59: 267–285.
- , . 2004. Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res 59: 305–331.
- , , . 2004. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304: 108–110.
- , , , , . 1995. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546–549.
- , , , , , , , . 2001. Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest 108: 1113–1121.
- , , , , , , , , , , , . 2005. The hypothalamic arcuate nucleus: A key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab 1: 63–72.
- , , , , , , . 2006. Hypothalamic mTOR signaling regulates food intake. Science 312: 927–930.
- , . 1964. Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol Scand Suppl 232: 231–255.
- , , , , , , , . 2001. Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus. Science 291: 2608–2613.
- , , , , , , , , , , , , . 1998. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol 402: 442–459.Direct Link:
- , . 1996. Activation of neurons projecting to the paraventricular hypothalamic nucleus by intravenous lipopolysaccharide. J Comp Neurol 374: 315–331.Direct Link:
- , , , , . 1998. Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol 395: 535–547.Direct Link:
- , , , , , , . 1997. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci U S A 94: 7001–7005.
- , , , . 2002. Leptin uptake by serotonergic neurones of the dorsal raphe. J Neuroendocrinol 14: 429–434.Direct Link:
- , , , , . 2003. Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat. Brain Res 964: 107–115.
- , , , , , , . 2004. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A 101: 4661–4666.
- , , , , , . 1996. Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci U S A 93: 6231–6235.
- . 2000. Leptin—much more than a satiety signal. Annu Rev Nutr 20: 45–75.
- , . 1982. Activating antibodies to tyrosine hydroxylase. J Biol Chem 257: 9416–9423.
- , , . 1990. Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat. J Comp Neurol 293: 540–580.Direct Link:
- , , . 1988. Rat neuropeptide Y precursor gene expression. mRNA structure, tissue distribution, and regulation by glucocorticoids, cyclic AMP, and phorbol ester. J Biol Chem 263: 6288–6295.
- , , , , , , , , , . 2008. Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. J Clin Invest 118: 1796–1805.
- , , , , . 2002. Brain stem is a direct target for leptin's action in the central nervous system. Endocrinology 143: 3498–3504.
- , , , , . 1996. Localization of leptin receptor mRNA expression in mouse brain. Neuroreport 7: 2635–2638.
- , , , , , , , . 2003. Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci 23: 7143–7154.
- , , , , , . 1996. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett 387: 113–116.
- , , . 1998. Localization of leptin receptor (Ob-R) messenger ribonucleic acid in the rodent hindbrain. Endocrinology 139: 29–34.
- , , , , , , , , , , , . 2004. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428: 569–574.
- , , , , , , . 2003. Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology 144: 2016–2024.
- , , , , , , , . 2005. Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest 115: 703–710.
- , , , , . 2003. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology 144: 2121–2131.
- , . 2003. Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Front Neuroendocrinol 24: 1–10.
- , , , , , . 2001. Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature 413: 794–795.
- , . 2001. The mouse brain in stereotaxic coordinates, 2nd ed. San Diego: Academic Press.
- , , 2008. Molecular and neural mediators of leptin action. Physiol Behav 94: 637–642.
- , , , , . 2000. Central nervous system control of food intake. Nature 404: 661–671.
- , , , , , , , , , . 1996. Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats. Horm Metab Res 28: 664–668.
- , , , , , . 1998. Immunohistochemical localization of leptin receptor in the rat brain. Neurosci Lett 243: 41–44.
- , , . 1989. A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radiolabelled single stranded RNA probes. J Histotechnol 12: 169–181.
- , . 2001. Obesity and the regulation of energy balance. Cell 104: 531–543.
- , , , , , , . 2001. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol 1: 4.
- , , . 2000. Dopamine is required for hyperphagia in Lep(ob/ob) mice. Nat Genet 25: 102–104.
- , , , . 2006. The role of leptin in the development of the cortical neuron in mouse embryos. Brain Res 1120: 74–82.
- , , , , , , , , , , , , , , , , 2008. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology 149: 1773–1785.
- , , , , , . 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425–432.
- , . 2003. Minireview: from anorexia to obesity—the yin and yang of body weight control. Endocrinology 144: 3749–3756.
- , , , , , . 2000. Differential regulation of leptin transport by the choroid plexus and blood-brain barrier and high affinity transport systems for entry into hypothalamus and across the blood-cerebrospinal fluid barrier. Endocrinology 141: 1434–1441.

1096-9861/asset/CNE_left.gif?v=1&s=2a41ed6f9545170128d22f1b6422e32d31eb4015)
