Distribution of mRNAs encoding transforming growth factors-β1, -2, and -3 in the intact rat brain and after experimentally induced focal ischemia
Version of Record online: 20 MAY 2010
Copyright © 2010 Wiley-Liss, Inc.
Journal of Comparative Neurology
Volume 518, Issue 18, pages 3752–3770, 15 September 2010
How to Cite
Vincze, C., Pál, G., Wappler, E. A., Szabó, É. R., Nagy, Z. G., Lovas, G. and Dobolyi, A. (2010), Distribution of mRNAs encoding transforming growth factors-β1, -2, and -3 in the intact rat brain and after experimentally induced focal ischemia. J. Comp. Neurol., 518: 3752–3770. doi: 10.1002/cne.22422
- Issue online: 13 JUL 2010
- Version of Record online: 20 MAY 2010
- Accepted manuscript online: 20 MAY 2010 12:00AM EST
- Manuscript Accepted: 6 APR 2010
- Manuscript Revised: 18 MAR 2010
- Manuscript Received: 24 NOV 2009
- Hungarian Scientific Research Fund. Grant Numbers: NFM-OTKA NNF78219, NKTH-OTKA K67646, NKTH-OTKA K69240
Additional Supporting Information may be found in the online version of this article.
|CNE_22422_sm_suppinfofigure.tif||6206K||Dark-field photomicrographs of in situ hybridization sections demonstrate the absence of labeling by using control sense in situ hybridization probes for TGF-βs. A: The presence of TGF-β1 mRNA is shown in the paraventricular hypothalamic nucleus (PVN) by using an antisense probe. B: The same field of an adjacent section hybridized with a TGF-β1 control sense probe demonstrates no labeling. C: The distribution of TGF-β2 mRNA is shown in a photomicrograph of an area including parts of the cerebral cortex (Cx) by using an antisense probe. Labeling is intense in layer V. of the cortex, and also in the choroid plexus within the lateral ventricle. D: The same field of an adjacent section hybridized with a TGF-β2 control sense probe demonstrates no labeling. E: The distribution of TGF-β3 mRNA is shown in the anterior thalamus by using an antisense probe. TGF-β3 mRNA is present in the paraventricular thalamic nucleus (PVT), the reticular thalamic nucleus (Re), and the anterior thalamic nuclei including the anteromedial thalamic nucleus (AM). F: The same field of an adjacent section hybridized with a TGF-β3 control sense probe demonstrates no labeling. Additional abbreviations include fi: fimbria hippocampi, ic: internal capsule, ot: optic tract, sm: stria medullaris, and 3V: third ventricle. Scale bar = 1 mm.|
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