A Distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis

Authors

  • Emily A. Mathews,

    1. Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037
    2. Department of Neurosciences, The University of California, San Diego, La Jolla, California 92093
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  • Nicolás A. Morgenstern,

    1. Laboratory of Neuronal Plasticity, Leloir Institute—CONICET, 1405 Buenos Aires, Argentina
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  • Verónica C. Piatti,

    1. Laboratory of Neuronal Plasticity, Leloir Institute—CONICET, 1405 Buenos Aires, Argentina
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  • Chunmei Zhao,

    1. Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037
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  • Sebastian Jessberger,

    1. Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037
    Current affiliation:
    1. Institute of Cell Biology Studies, Department of Biology, ETH Zurich, 8093 Zurich, Switzerland
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  • Alejandro F. Schinder,

    1. Laboratory of Neuronal Plasticity, Leloir Institute—CONICET, 1405 Buenos Aires, Argentina
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  • Fred H. Gage

    Corresponding author
    1. Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037
    • The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, CA 92037
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Abstract

Retroviral labeling of granule cells of the adult mouse reveals an outside-in layering based on birthdate. Green–granule cells labeled by retrovirus CAG–GFP at E15. Magenta–granule cells labeled by retrovirus CAG-RFP at P42. The Journal of Comparative Neurology, Volume 518, Number 22, 4479–4490.

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