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Additional Supporting Information may be found in the online version of this article.

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CNE_22787_sm_SuppInfoFig1.tif3492KSuppl. Figure 1. A-D: Low- and high power photomicrographs of double immunofluorescence (A-C) and double immunoperoxidase (D) staining for PHA-L (magenta fluorescence, black peroxidase product) and CTb (red fluorescence, brown peroxidase product) in the RMTg. PHA-L labeling results from a large injection centered in the central one-third of the LHb (case R82) and CTb labeling from a large VTA injection centered in the PBP. Note that varicose PHA-L labeled axons are found in close register with CTb labeled neurons and form numerous close appositions with the latter (indicated by arrowheads). The corresponding red-green version of this Figure is provided as Figure 10 in the paper. Scale bar = 100 μm in A; 10 μm in B-D.
CNE_22787_sm_SuppInfoFig2.tif258KSuppl. Figure 2. Schematic diagram of major afferent and efferent connections of the habenula. This diagram is based on connections defined in the present study (solid lines) and literature data (dashed lines). Note that the diagram is highly simplified. Thus, many of the depicted connections are reciprocal and there are rich interconnections between most of the mesopontine and mesencephalic structures included in the diagram. For reasons of simplicity, these connections are not shown. The corresponding red-green version of this Figure is provided as Figure 12 in the paper. Scheme partially adapted from Hikosaka et al. (2008). For abbreviations, see list.

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