Glucagon-like peptide-1 in the rat brain: Distribution of expression and functional implication
Article first published online: 19 APR 2013
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Comparative Neurology
Volume 521, Issue 10, pages 2235–2261, 1 July 2013
How to Cite
Gu, G., Roland, B., Tomaselli, K., Dolman, C. S., Lowe, C. and Heilig, J. S. (2013), Glucagon-like peptide-1 in the rat brain: Distribution of expression and functional implication. J. Comp. Neurol., 521: 2235–2261. doi: 10.1002/cne.23282
- Issue published online: 19 APR 2013
- Article first published online: 19 APR 2013
- Accepted manuscript online: 14 DEC 2012 07:35AM EST
- Manuscript Accepted: 7 DEC 2012
- Manuscript Revised: 17 SEP 2012
- Manuscript Received: 11 MAY 2012
- Amylin Pharmaceuticals, LLC
Additional Supporting Information may be found in the online version of this article.
|CNE_23282_sm_SuppFig6.tif||9850K||Supporting Information Figure 6. (Magenta-green version of Figure 6 the assistance of color-blind readers). Confocal microscopic images (projection of 10 optical planes) showing GLP (green) (A), FOS (red) (B) expression, and the overlay image (C) in the medical subnucleus of the nucleus of the solitary tract in an exendin-4 treated rat. GLP-ir cell bodies (arrows) are located in the ventrolateral part of the subnucleus and only one GPPs-ir cell (arrow head) in this section was found to co-express FOS. Scale bar: 50 μM.|
|CNE_23282_sm_SuppFig7.tif||20613K||Supporting Information Figure 7. (Magenta-green version of Figure 7 for the assistance of color-blind readers). Confocal microscopic images (projection of 10 optical planes) that show the colocalization of GLP immunoreactive axons (green) and FOS expression (red) in the external subnucleus of the lateral parabrachial nucleus (PBle) (A), the paraventricular nucleus of the thalamus (PVT) (B), the oval nucleus of the bed nuclei of the stria terminalis (BSTov) (C), the central nucleus of the amygdala (CEA) (D), the paraventricular nucleus of the hypothalamus (PVH) (E), and the dorsomedial nucleus of the hypothalamus (DMH) (F). FOS-positive nuclei are highly colocalized with GLP-ir terminals in these selected regions CEAl, lateral part of the CEA; CEAm, medial part of the CEA; DMHa, anterior part of the DMH; DMHp, posterior part of the DMH; PVHmpd, dorsal zone of parvicellular part of the PVH; PVHpml, lateral zone of posterior magnocellular part of the PVH; scp, superior cerebellar peduncle; V3, third ventricle. Scale bar:100 μm.|
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