This work was supported by Grants Number GM1789 from PHS and GB-4198 from NSF to Dr. Carl Pfaffmann Rockefeller University. The authors thank Miss S. Tegner Mcateer and Miss Vimol Surapipith for their excellent technical and artistic assistance. We would also like to thank Dr. W.J.H. Nauta and Dr. Donald Pfaff for their helpful auggestions on the manuscript.
Origin and distribution of the amygdalofugal pathways in the rat: An experimental neuronatomical study†
Article first published online: 9 OCT 2004
Copyright © 1971 The Wistar Institute Press
Journal of Comparative Neurology
Volume 141, Issue 3, pages 313–329, March 1971
How to Cite
Leonard, C. M. and Scott, J. W. (1971), Origin and distribution of the amygdalofugal pathways in the rat: An experimental neuronatomical study. J. Comp. Neurol., 141: 313–329. doi: 10.1002/cne.901410304
- Issue published online: 9 OCT 2004
- Article first published online: 9 OCT 2004
The fields of origin of the amygdalofugal pathways in the albino rat were studied by using the Fink-Heimer technique to stain degenerating fibers and terminals in brains of animals sacrificed four and seven days after small unilateral lesions of the amygdale. A surprisingly restricted field of origin was found for the supracommissural stria terminalis — the component projecting to the ventromedial nucleus of the hypothalamus Only a lesion in the most posterior part of the cortical nucleus produced degeneration in this pathway. The postcommissural stria terminalis which apparently distributes to the bed nucleus of the stria terminalis and preoptic area originates in a more widespread area including parts of both the basolateral and corticomedial complexes. Although intense terminal degeneration could be seen within the amygdala following all lesions, long fibers projecting into the anterior amygdaloid area, lateral preoptic area and lateral hypothalamus were found only after lesions in which fibers of passage from periamygdaloid cortex could have been interrupted. Convincing evidence, therefore, of a long axon ventral amygdalofugal pathway of the rat was not found in this study.