Presented in part at the sixth meeting of the American Society for Neurochemistry, Mexico City, March, 1975.
Article first published online: 9 OCT 2004
Copyright © 1976 The Wistar Institute of Anatomy and Biology
Journal of Comparative Neurology
Volume 165, Issue 2, pages 197–207, 15 January 1976
How to Cite
Ludwin, S. K., Kosek, J. C. and Eng, L. F. (1976), The topographical distribution of S-100 and GFA proteins in the adult rat brain: An immunohistochemical study using horseradish peroxidase-labelled antibodies. J. Comp. Neurol., 165: 197–207. doi: 10.1002/cne.901650206
This research was supported by the Veterans Administration, MR IS 2390 and 5022, by Grant NS 11632 from the National Institutes of Health, U. S. Public Health Service, and by Neuropathology Graduate Training Grant 5 TO1 NS 05500-09 from the National Institute of Neurological Diseases and Stroke, U.S.P.H.S.
- Issue published online: 9 OCT 2004
- Article first published online: 9 OCT 2004
The cytological and topographical distribution of S-100 and glial fibrillary acidic (GFA) proteins in the adult rat brain has been compared using the horseradish peroxidase-labelled antibody technique. Both proteins are present in astrocytes and structures composed of astrocytic processes, namely the glial limitans and the perivascular membranes, but the cytological localization varies between the two proteins. S-100 is found in the nucleus and cytoplasm whereas GFA protein is confined to the cytoplasm. Neither is found in neurons, but S-100 is present in some oligodendroglia, suggesting a general regulatory role in glia. Although GFA protein is present in both protoplasmic and fibrous astrocytes, it is more prominent in the latter, confirming its association with astrocytic filaments.