The distribution of substance P immunoreactive fibers in the rat central nervous system

Authors

  • A. Claudio Cuello,

    1. MRC Neurochemical Pharmacology Unit, Department of Pharmacology, Hills Road, Cambridge CB2 2QD United Kingdom
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  • Ichiro Kanazawa

    1. MRC Neurochemical Pharmacology Unit, Department of Pharmacology, Hills Road, Cambridge CB2 2QD United Kingdom
    Current affiliation:
    1. Department of Neurology, Faculty of Clinical Medicine, University of Tsukuba, Japan 300-31
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  • Dedicated to the memory of Sir John H. Gaddum.

Abstract

A detailed account of the distribution of immunoreactive substance P-containing structures in the rat central nervous system is presented, from results obtained by applying an indirect immunofluorescent technique. High densities of substance P-containing nerve terminals were present in sensory nuclei and other non-sensory structures such as thalamus, hypothalamus and extrapyramidal system. Substance P-reactive neuron cell bodies were present in spinal root ganglia, nucleus habenulae medialis, nucleus interpeduncularis, caudoputamen and globus pallidus. Most of the neocortex and the cerebellar cortices had no substance P-positive elements. The results support the hypothesis that substance P may be a widespread neurotransmitter in the central nervous system.

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