Jae-Hyuk Yi, Yasuhiro Katagiri, Bala Susarla, David Figge, Aviva J. Symes and Herbert M. Geller
Chondroitin sulfate proteoglycans (CSPGs) are major growth-inhibitory molecules found in the glial scar following an insult to the central nervous system. By using a cortical contusion injury model in mice, we show that the injury causes both an increased level of 4-sulfated glycosaminoglycan (GAGs) in the tight band around the lesion core, and a decreased level of aggrecan and phosphacan in the pericontusional cortex. These results demonstrate a region-specific change in CSPGs following a cortical contusion injury. PNN, perineuronal net.