Journal of Comparative Neurology

Cover image for Vol. 520 Issue 17

1 December 2012

Volume 520, Issue 17

Pages Spc1–Spc1, 3803–4049

  1. Cover Image

    1. Top of page
    2. Cover Image
    3. Research Articles
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  2. Research Articles

    1. Top of page
    2. Cover Image
    3. Research Articles
    1. Developmental dynamics of PAFAH1B subunits during mouse brain development (pages 3877–3894)

      Teresa Escamez, Olga Bahamonde, Rafael Tabares-Seisdedos, Eduard Vieta, Salvador Martinez and Diego Echevarria

      Version of Record online: 3 OCT 2012 | DOI: 10.1002/cne.23128

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      We investigated the PAFAH1B complex (ALPHA1, ALPHA2, and LIS1) during brain development until adulthood in normal mice and in mice in which a small deletion was made of the first coding exon in one allele (Lis1/sLis1). Analysis was performed in the forebrain and hindbrain and on eye development by using in situ hybridization and real-time PCR quantification techniques. The results revealed different putative roles for each subunit of the LIS1 complex during neural differentiation and neural migration processes.

    2. Expression of EAAT2 in neurons and protoplasmic astrocytes during human cortical development (pages 3912–3932)

      Tara M. DeSilva, Natalia S. Borenstein, Joseph J. Volpe, Hannah C. Kinney and Paul A. Rosenberg

      Version of Record online: 1 OCT 2012 | DOI: 10.1002/cne.23130

    3. Melanocortin-4 receptor expression in different classes of spinal and vagal primary afferent neurons in the mouse (pages 3933–3948)

      Laurent Gautron, Charlotte E. Lee, Syann Lee and Joel K. Elmquist

      Version of Record online: 1 OCT 2012 | DOI: 10.1002/cne.23137

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      Melanocortin-4 receptor (MC4R) ligands are known to modulate nociception, but the site of action of MC4R signaling on nociception remains to be elucidated. The current study investigates MC4R expression in the nodose ganglion (vagal) and dorsal root ganglion (spinal) of the MC4R-GFP reporter mouse. Using immunohistochemistry combined with in situ hybridization and double-labeling immunohistochemistry, we demonstrated abundant GFP expression in non-peptidergic nociceptors of the dorsal root ganglion and varied viscerosensory neurons of the nodose ganglion. Collectively, our anatomical findings reveal a new site of actions for the melanocortin system on nociception, and underscore the role of MC4R signaling in various vagal and spinal sensory modalities.

    4. Fibroblast growth factor 2 regulates adequate nigrostriatal pathway formation in mice (pages 3949–3961)

      Olga Baron, Andreas Ratzka and Claudia Grothe

      Version of Record online: 1 OCT 2012 | DOI: 10.1002/cne.23138

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      Combination of the ventral midbrain and forebrain tissue from wild type and mutant E14.5 embryonic mice provide a good model to study the complex interplay of target derived and source derived signaling under controlled conditions. Present coculture study provides the evidence that FGF-2 participates in nigrostriatal pathway formation and target innervation. Further, the adequate nigrostriatal wiring depends on both target derived and midbrain derived FGF-2. Thereby, the target derived FGF-2 might regulate glia migration and thereby indirectly mDA fiber outgrowth.

    5. Dopamine and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells (pages 4032–4049)

      Genki Ogata, Tyler W. Stradleigh, Gloria J. Partida and Andrew T. Ishida

      Version of Record online: 1 OCT 2012 | DOI: 10.1002/cne.23159

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      Dopamine modulates numerous cellular properties in retinae, and was previously found to do so by D1 receptor-driven cAMP increases or D2 receptor-driven cAMP decreases. We provide evidence that dopamine can operate differently on adult mammalian retinal ganglion cells. SKF 83959 and exogenous dopamine increased intracellular Ca2+ and inhibited spike firing. Illumination, known from other studies to release endogenous dopamine, elevated cAMP and activated CaMKII in single ganglion cells. All of these effects were blocked by D1 and D2 receptor antagonists.