Developmental dynamics of PAFAH1B subunits during mouse brain development (pages 3877–3894)
Teresa Escamez, Olga Bahamonde, Rafael Tabares-Seisdedos, Eduard Vieta, Salvador Martinez and Diego Echevarria
Article first published online: 3 OCT 2012 | DOI: 10.1002/cne.23128
We investigated the PAFAH1B complex (ALPHA1, ALPHA2, and LIS1) during brain development until adulthood in normal mice and in mice in which a small deletion was made of the first coding exon in one allele (Lis1/sLis1). Analysis was performed in the forebrain and hindbrain and on eye development by using in situ hybridization and real-time PCR quantification techniques. The results revealed different putative roles for each subunit of the LIS1 complex during neural differentiation and neural migration processes.