Cell death atlas of the postnatal mouse ventral forebrain and hypothalamus: Effects of age and sex (pages 2551–2569)
Todd H. Ahern, Stefanie Krug, Audrey V. Carr, Elaine K. Murray, Emmett Fitzpatrick, Lynn Bengston, Jill McCutcheon, Geert J. De Vries and Nancy G. Forger
Version of Record online: 4 JUN 2013 | DOI: 10.1002/cne.23298
We used immunocytochemistry for activated caspase-3 (AC3) to quantify developmental cell death in the hypothalamus and ventral forebrain of male and female mice between postnatal day (P) 1 and P11. The peak of cell death varied between P1 and P7, and rate of cell death varied over fivefold among the 16 regions examined. Several sex differences in cell death or regional volume were observed, and for almost all regions a significant reduction in cell death occurred between P5 and P7.