Journal of Comparative Neurology

Cover image for Vol. 521 Issue 13

1 September 2013

Volume 521, Issue 13

Pages Spc1–Spc1, 2889–3132

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    4. Research Articles
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  2. Toolbox

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    4. Research Articles
    1. Neural systems language: A formal modeling language for the systematic description, unambiguous communication, and automated digital curation of neural connectivity (pages 2889–2906)

      Ramsay A. Brown and Larry W. Swanson

      Version of Record online: 17 JUL 2013 | DOI: 10.1002/cne.23348

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      Systematicity in description and communication of observations and results is imperative for automated mass-scale synthesis of anatomical and neural connectivity data, yet remains historically elusive. The Neural Systems Language (NSyL) is a novel modeling language and notation for systematically representing and communicating neural circuit connectivity. NSyL describes connectivity irrespective of the animal taxon described, experimental or observational technique implemented, anatomical nomenclature referenced, or online database used for analysis. NSyL engenders the systematicity imperative for modern systems neuroscience and connectomics.

  3. Research Articles

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    4. Research Articles
    1. Monosynaptic convergence of chorda tympani and glossopharyngeal afferents onto ascending relay neurons in the nucleus of the solitary tract: A high-resolution confocal and correlative electron microscopy approach (pages 2907–2926)

      James A. Corson and Alev Erisir

      Version of Record online: 17 JUL 2013 | DOI: 10.1002/cne.23357

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      By using high-resolution confocal and electron microscopy, the authors demonstrate monosynaptic convergence of the chorda tympani and glossopharyngeal nerves onto individual ascending projection neurons in the rostral nucleus of the solitary tract. This circuit arrangement is likely crucial in the initial processing of orosensory information.

    2. Somatodendritic targeting of M5 muscarinic receptor in the rat ventral tegmental area: Implications for mesolimbic dopamine transmission (pages 2927–2946)

      Miguel Garzón and Virginia M. Pickel

      Version of Record online: 17 JUL 2013 | DOI: 10.1002/cne.23323

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      We have shown that the muscarinic M5 receptor subtype is located primarily in somatodendritic compartments of midbrain ventral tegmental area neurons, but also in some of their afferent axon terminals. These potential activation sites confer on the M5R subtype a critical position for fine adjustment of dopamine (DA)-related mesocorticolimbic-guided behaviors. DAT, dopamine transporter.

    3. Muscle ciliary neurotrophic factor receptor α promotes axonal regeneration and functional recovery following peripheral nerve lesion (pages 2947–2965)

      Nancy Lee, Rachel P. Spearry, Kendra M. Leahy, Rachel Robitz, Dennis S. Trinh, Carter O. Mason, Rebekah J. Zurbrugg, Myra K. Batt, Richard J. Paul and A. John Maclennan

      Version of Record online: 17 JUL 2013 | DOI: 10.1002/cne.23324

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      We selectively depleted muscle ciliary neurotrophic factor receptor α (CNTFRα), an essential CNTF receptor component, in vivo and found that it contributes to motor neuron axonal regeneration across the site of peripheral nerve lesions and normal recovery of motor function. Surprisingly, we found no role for muscle CNTFRα in the maintenance or regeneration of the muscle itself.

    4. Segregation of parallel inputs to the anteromedial and anteroventral thalamic nuclei of the rat (pages 2966–2986)

      Nicholas F. Wright, Seralynne D. Vann, Jonathan T. Erichsen, Shane M. O'Mara and John P. Aggleton

      Version of Record online: 17 JUL 2013 | DOI: 10.1002/cne.23325

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      Double-fluorescent retrograde neuronal tracing techniques reveal the organization of projections into the anteroventral and anteromedial thalamic nuclei. Results show that, despite projections often originating from shared regions, there is a very high level of segregation in cortical and limbic inputs into these nuclei, with very few bifurcating neurons innervating both nuclei.

    5. Elucidation of target muscle and detailed development of dorsal motor neurons in chick embryo spinal cord (pages 2987–3002)

      Nobumi Kobayashi, Shunsaku Homma, Tomoaki Okada, Tomoyuki Masuda, Noboru Sato, Keiji Nishiyama, Chie Sakuma, Takako Shimada and Hiroyuki Yaginuma

      Version of Record online: 17 JUL 2013 | DOI: 10.1002/cne.23326

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      Dorsal motoneurons, which send peripheral axons through the dorsal root, have been repeatedly described in the cervical spinal cord of avian embryos for more than 100 years. However, their target muscles have not been revealed until today. Here we show that their target muscle is the cucullaris muscle and that these motoneurons express molecular markers that are similar to those of the branchial motoneurons in the brainstem.

    6. Socially regulated reproductive development: Analysis of GnRH-1 and kisspeptin neuronal systems in cooperatively breeding naked mole-rats (Heterocephalus glaber) (pages 3003–3029)

      Shuzhi Zhou, Melissa M. Holmes, Nancy G. Forger, Bruce D. Goldman, Matthew B. Lovern, Alain Caraty, Imre Kalló, Christopher G. Faulkes and Clive W. Coen

      Version of Record online: 17 JUL 2013 | DOI: 10.1002/cne.23327

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      In naked mole-rat (NMR) colonies, the queen and her consorts monopolize breeding. This study has quantified GnRH-1- and kisspeptin-immunoreactive (ir) neurons and plasma gonadal steroids in breeders and subordinates. Extensive species comparisons show NMRs to be novel: substantial numbers of kisspeptin-ir cell bodies are detected in the rostral periventricular region (including the AVPV) and arcuate and dorsomedial hypothalamic nuclei, irrespective of reproductive status, plasma gonadal steroids or sex. Nevertheless, rostral periventricular kisspeptin-ir cell bodies are more numerous in female breeders than female subordinates.

    7. Seasonal changes in RFamide-related peptide-3 neurons in the hypothalamus of a seasonally breeding marsupial species, the brushtail possum (Trichosurus vulpecula) (pages 3030–3041)

      Anan A. Harbid, Bernie J. McLeod, Alain Caraty and Greg M. Anderson

      Version of Record online: 17 JUL 2013 | DOI: 10.1002/cne.23328

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      RFRP-3 exhibits a pronounced seasonal fluctuation in cell numbers in the brushtail possum hypothalamus, suggesting an increased inhibitory tone during the non-breeding season. The lack of RFRP-3 fibers in the median eminence and of Fluoro-Gold uptake from the periphery imply its actions occur centrally rather than at the pituitary gland.

    8. Vesicular glutamate transporter-3 in the rodent brain: Vesicular colocalization with vesicular γ-aminobutyric acid transporter (pages 3042–3056)

      M.J. Stensrud, F.A. Chaudhry, T.B. Leergaard, J.G. Bjaalie and V. Gundersen

      Version of Record online: 17 JUL 2013 | DOI: 10.1002/cne.23331

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      Prior to release, glutamate is packed into synaptic vesicles by a family of vesicular glutamate transporters (VGLUT1–3). VGLUT3 is known to be located in nonglutamatergic neurons. We show that VGLUT3 is localized on synaptic vesicles together with the vesicular GABA transporter (VGAT) in GABAergic nerve terminals in the neocortex and the hippocampus. In the striatum, VGLUT3 is present on synaptic vesicles in cholinergic but not in GABAergic terminals. This suggests that glutamate and GABA are coreleased in certain brain regions, leading to a more sophisticated modulation of brain signaling than previously thought.

    9. Glycine-immunoreactive neurons in the brain of a shark (Scyliorhinus canicula L.) (pages 3057–3082)

      Ramón Anadón, Isabel Rodríguez-Moldes and Fátima Adrio

      Version of Record online: 17 JUL 2013 | DOI: 10.1002/cne.23332

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      By using glycine immunofluorescence, we describe for the first time the putative glycinergic populations of the brain of a shark. The dogfish shares some glycinergic populations with other fishes but shows notable differences in the telencephalic lobes and cerebellum, which reveals divergent evolution of glycinergic systems of early vertebrate groups.

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      Stimulation of the midbrain periaqueductal gray modulates preinspiratory neurons in the ventrolateral medulla in the rat in vivo (pages 3083–3098)

      Hari H. Subramanian and Gert Holstege

      Version of Record online: 17 JUL 2013 | DOI: 10.1002/cne.23334

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      The midbrain periaqueductal gray (PAG) is known to generate those behaviors necessary to survive the circumstances in which animals find themselves. We show that, within this context, the PAG excites the pre-I neurons of the pre-Bötzinger complex both phasically and tonically, or even silences them, depending on which behavior is necessary.

    11. Increased radial glia quiescence, decreased reactivation upon injury and unaltered neuroblast behavior underlie decreased neurogenesis in the aging zebrafish telencephalon (pages 3099–3115)

      Kathrin Edelmann, Lena Glashauser, Susanne Sprungala, Birgit Hesl, Maike Fritschle, Jovica Ninkovic, Leanne Godinho and Prisca Chapouton

      Version of Record online: 17 JUL 2013 | DOI: 10.1002/cne.23347

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      In the adult zebrafish, radial glial cells (depicted in green and yellow on a cross section of the telencephalon) cover the ventricular area, on the outer surface and at the midline and span their process towards the pial surface. Divisions of the radial glia (yellow) and of their neuroblasts offsprings (yellow dots) are at the source of the newly born neurons (red dots). Mitotic activity of the radial glia diminishes with age and neurogenesis is reduced: compare the “old” right hemisphere.to the “young” left hemisphere. (The cells within the section are represented at a larger scale for the sake of simplicity).

    12. Electrophysiological and morphological characterization of cells in superficial layers of rat presubiculum (pages 3116–3132)

      Saad Abbasi and Sanjay S. Kumar

      Version of Record online: 17 JUL 2013 | DOI: 10.1002/cne.23365

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      This study characterizes/classifies neuron types in superficial layers of the rat presubiculum based on physiological properties assayed via whole-cell recordings while correlating their gross morphology through biocytin labeling. The identification of seven physiologically distinct neuron types suggests the presubiculum as being a more neuronally diverse structure than previously envisaged.

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