Journal of Comparative Neurology

Cover image for Vol. 521 Issue 3

15 February 2013

Volume 521, Issue 3

Pages Spc1–Spc1, 499–724

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    3. Research Articles
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  2. Research Articles

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    3. Research Articles
    1. The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis (pages 499–521)

      Jeffrey Helgager, Gumei Liu and James O. McNamara

      Version of Record online: 17 DEC 2012 | DOI: 10.1002/cne.23225

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      Signaling through the neurotrophin receptor, tropomyosin-related kinase B (TrkB), is thought to be critical for limbic epileptogenesis, the process by which a normal brain becomes epileptic. This study elucidates the locales of activated TrkB within the hippocampus in a mouse model of epileptogenesis, revealing its presence at cellular and synaptic locales within mossy fibers and CA1 pyramidal cells. Knowledge of where TrkB undergoes activation is necessary to understand its functional consequences, and may facilitate an understanding of the cellular mechanisms of epileptogenesis.

    2. Glutamatergic neuronal populations in the brainstem of the sea lamprey, Petromyzon marinus: An in situ hybridization and immunocytochemical study (pages 522–557)

      Verona Villar-Cerviño, Antón Barreiro-Iglesias, Blanca Fernández-lópez, Sylvie Mazan, María Celina Rodicio and Ramón Anadón

      Version of Record online: 17 DEC 2012 | DOI: 10.1002/cne.23189

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      The present in situ hybridization study provides an anatomical basis for the localization of glutamatergic neurons in the lamprey brainstem. We also combined glutamate immunohistochemistry with neuronal tract-tracing methods or γ-aminobutyric acid (GABA) immunohistochemistry. The results indicate that glutamate immunohistochemistry did not reveal the entire set of glutamatergic populations demonstrated by expression of vesicular glutamate transporter (VGLUT) mRNA, and this applies to the largest reticulospinal neurons. Colocalization of glutamate and GABA was observed in some small neurons, suggesting co-release of GABA and glutamate.

    3. Differential roles of ventral pallidum subregions during cocaine self-administration behaviors (pages 558–588)

      David H. Root, Sisi Ma, David J. Barker, Laura Megehee, Brendan M. Striano, Carla M. Ralston, Anthony T. Fabbricatore and Mark O. West

      Version of Record online: 17 DEC 2012 | DOI: 10.1002/cne.23191

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      Dorsolateral ventral pallidum (VPdl) neurons exhibit greater changes in firing rate (FR) during cocaine-seeking responses than ventromedial ventral pallidum (VPvm) neurons. y Axis is cumulative proportion of neurons; x axis is absolute change in FR during response. Red and black lines indicate cumulative proportions for VPdl and VPvm neurons, respectively. Median values are circle (VPdl) and square (VPvm). Accumbens shell and core project to VPvm and VPdl, respectively, suggesting that the core-VPdl subcircuit is especially critical for drug-seeking behavior. **P < 0.01.

    4. Cellular components of the human medial amygdaloid nucleus (pages 589–611)

      Aline Dall'Oglio, Léder L. Xavier, Arlete Hilbig, Denise Ferme, Jorge E. Moreira, Matilde Achaval and Alberto A. Rasia-Filho

      Version of Record online: 17 DEC 2012 | DOI: 10.1002/cne.23192

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      Novel morphological data about neurons and glial cells in the human medial amygdaloid nucleus were obtained. This nucleus has more neurons in the left hemisphere and more glia (72% of all cells) than neurons. Five types of multipolar neurons were found, fusiform ones were the most frequent. Pleomorphic spines, complex axonal collateral terminations, and ramified protoplasmic astrocytes were observed. At the ultrastructural level, there were asymmetric and symmetric synaptic sites and multisynaptic glomerular-like terminals.

    5. Postnatal expression of TrkB receptor in rat vestibular nuclear neurons responsive to horizontal and vertical linear accelerations (pages 612–625)

      Chun-Wai Ma, Fu-Xing Zhang, Chun-Hong Lai, Suk-King Lai, Ken Kin-Lam Yung, Daisy Kwok-Yan Shum and Ying-Shing Chan

      Version of Record online: 17 DEC 2012 | DOI: 10.1002/cne.23193

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      Using immunohistochemical approach, the authors show the maturation profile of TrkB receptor-expressing neurons that specifically encode horizontal or vertical otolith signals. The finding provides useful framework for functional studies on the role of BDNF/TrkB signaling in the developmental establishment of neural circuitry for coding head movement in three-dimensional planes.

    6. Role of EphA/ephrin-A signaling in the development of topographic maps in mouse corticothalamic projections (pages 626–637)

      Masaaki Torii, Pasko Rakic and Pat Levitt

      Version of Record online: 17 DEC 2012 | DOI: 10.1002/cne.23195

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      Corticothalamic (CT) connections play important roles in the fine-tuning of sensory information that the brain processes. We show, in the mouse, that the somatosensory maps that form during development are established through the precise targeting of cortical axons to their correct areas within the thalamus. The axons then progressively increase their processes in the appropriate zones over 2 weeks. The targeting and growth are regulated by spatially and temporally coordinated EphA/ephrin-A signaling on CT axons in their target areas.

    7. Nonuniform distribution of contacts from noradrenergic and serotonergic boutons on the dendrites of cat splenius motoneurons (pages 638–656)

      Steven J. Montague, Keith K. Fenrich, Colin Mayer-Macaulay, Robert Maratta, Monica S. Neuber-Hess and P. Ken Rose

      Version of Record online: 17 DEC 2012 | DOI: 10.1002/cne.23196

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      Diffuse, yes; random, no. This phrase summarizes the organization of serotonergic (5-HT) and noradrenergic (NA) synapses in motoneuron nuclei. At the level of different motoneuron pools, these synapses are distributed with little or no order. However, at the level of the dendrites of individual motoneurons, this diffuse organization is transformed into precisely arranged domains. These domains may provide the basis for highly ordered interactions between 5-HT or NA synapses and specific combinations of excitatory and inhibitory synapses and voltage-dependent channels.

    8. Selective expression of α-synuclein-immunoreactivity in vesicular acetylcholine transporter-immunoreactive axons in the guinea pig rectum and human colon (pages 657–676)

      Dale F. Sharrad, Elsbeth de Vries and Simon J.H. Brookes

      Version of Record online: 17 DEC 2012 | DOI: 10.1002/cne.23198

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      Mishandling of α-synuclein contributes to formation of Lewy bodies and Lewy neurites in Parkinson's disease, which affects both the central and autonomic nervous systems. Here, we show α-synuclein is preferentially expressed in cholinergic enteric neurons, marked by vesicular acetylcholine transporter, but is less abundant in peptidergic or aminergic terminals. Thus, α-synuclein is not ubiquitously expressed in neurons. The results provide an anatomical basis for defects in distal bowel function that are associated with Parkinson's disease.

    9. Mutation of the BiP/GRP78 gene causes axon outgrowth and fasciculation defects in the thalamocortical connections of the mammalian forebrain (pages 677–696)

      Carlita B. Favero, Rasha N. Henshaw, Cynthia M. Grimsley-Myers, Ayushma Shrestha, David R. Beier and Noelle D. Dwyer

      Version of Record online: 17 DEC 2012 | DOI: 10.1002/cne.23199

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      The cerebral cortex communicates with the thalamus via reciprocal topographic axon connections that grow through a complex pathway. We show here that in baffled mutants, thalamocortical and corticothalamic axons are overfasciculated and delayed in pathfinding, particularly near the corticostriatal boundary. In dissociated culture, mutant neurons have shorter axons than controls. baffled mutants carry a hypomorphic mutation in the endoplasmic reticulum (ER) chaperone BiP/GRP78. Thus our findings add to accumulating evidence that ER functions are critical for axon outgrowth and pathfinding.

    10. The interfascicular trigeminal nucleus: A precerebellar nucleus in the mouse defined by retrograde neuronal tracing and genetic fate mapping (pages 697–708)

      Yuhong Fu, Petr Tvrdik, Nadja Makki, Robert Machold, George Paxinos and Charles Watson

      Version of Record online: 17 DEC 2012 | DOI: 10.1002/cne.23200

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      The interfascicular trigeminal nucleus (IF5) is a previously unreported nucleus, located among fibers of the motor trigeminal nerve in the mouse. Neurons in this position had previously been thought to supply an inner ear muscle, but we have found that IF5 projects to the cerebellum. IF5 shares many developmental features with other major nuclei that project to the cerebellum such as the pontine nuclei. The IF5 cells are labeled with magenta tracer and nearby motor neurons (5N) are stained green.

    11. Characterization of small-field bistratified amacrine cells in macaque retina labeled by antibodies against synaptotagmin-2 (pages 709–724)

      Sonja Neumann and Silke Haverkamp

      Version of Record online: 17 DEC 2012 | DOI: 10.1002/cne.23201

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      Amacrine cells are inhibitory neurons that are extremely diverse. They represent the largest class of retinal interneurons; however, so far the function of only a few of them is well understood. Here we demonstrate that synaptotagmin 2 (Syt2) is a marker for a distinct type of small-field bistratified amacrine cell in the macaque retina. We have used this marker to investigate the morphology, density, and connectivity pattern of Syt2-immunoreactive amacrine cells in central and peripheral macaque retina. GCL, ganglion cell layer; INL, inner nuclear layer; IPL, inner plexiform layer. Scale bar = 10 μm.