Journal of Comparative Neurology

Cover image for Vol. 521 Issue 8

1 June 2013

Volume 521, Issue 8

Pages Spc1–Spc1, 1697–1928

  1. Cover Image

    1. Top of page
    2. Cover Image
    3. Editorial
    4. Research Articles
    1. You have free access to this content
  2. Editorial

    1. Top of page
    2. Cover Image
    3. Editorial
    4. Research Articles
    1. You have free access to this content
      An important landmark in scientific publishing (pages 1697–1698)

      Harvey J. Karten, Jack R. Glaser and Patrick R. Hof

      Version of Record online: 4 APR 2013 | DOI: 10.1002/cne.23329

  3. Research Articles

    1. Top of page
    2. Cover Image
    3. Editorial
    4. Research Articles
    1. Retinorecipient areas in the diurnal murine rodent Arvicanthis niloticus: A disproportionally large superior colliculus (pages 1699–1726)

      Frédéric Gaillard, Harvey J. Karten and Yves Sauvé

      Version of Record online: 4 APR 2013 | DOI: 10.1002/cne.23303

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      The Nile grass rat is a diurnal murine rodent with 30–40% cones in its retina. Retinal efferents project to 45 subcortical structures involving all visual nuclei commonly described in rodents, a puzzling thalamic field, and the subgeniculate nucleus. Morphometric measurements reveal, moreover, that the retinorecipient layers of the superior colliculus in this animal are disproportionate compared with those in related nocturnal species. This feature may reflect an enlarged projection from cone-driven retinal ganglion cells.

    2. Laminar segregation of GABAergic neurons in the avian nucleus isthmi pars magnocellularis: A retrograde tracer and comparative study (pages 1727–1742)

      Macarena Faunes, Sara Fernández, Cristián Gutiérrez-Ibáñez, Andrew N. Iwaniuk, Douglas R. Wylie, Jorge Mpodozis, Harvey J. Karten and Gonzalo Marín

      Version of Record online: 4 APR 2013 | DOI: 10.1002/cne.23253

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      The nucleus isthmi magnocellularis (Imc) conveys heterotopic inhibition to the optic tectum (Teo) and the nucleus isthmi parvocellularis (Ipc). In the chick these projections arise from two cell types, which are found intermingled in the Imc. We show that in passerines and other nonrelated birds these cell types are segregated into an internal and an external subdivision. These results offer a comparative basis to investigate the role played by each cell type in the competitive interactions mediated by this nucleus. Imc-ex, external division of the Imc; Imc-in, internal division of the Imc; Slu, pars semiluminaris.

    3. Muscarinic cholinergic receptor M1 in the rat basolateral amygdala: Ultrastructural localization and synaptic relationships to cholinergic axons (pages 1743–1759)

      Jay F. Muller, Franco Mascagni, Violeta Zaric and Alexander J. McDonald

      Version of Record online: 4 APR 2013 | DOI: 10.1002/cne.23254

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      In this first ultrastructural analysis of the m1 cholinergic receptor in the basolateral amygdala, particulate m1 immunoreactivity was found in most spines (M1sp), and in the great majority of dendrites and perikarya. There were rarely accumulations of m1 immunoreactivity (m1-ir) directly postsynaptic to cholinergic axon terminals labeled with antibodies to the vesicular acetylcholine transporter (Vt; arrowhead indicates synapse), but accumulations of particulate m1-ir were frequently seen along the presynaptic membrane of m1-ir axon terminals forming synapses (M1t; asterisk indicates synapse).

    4. Anatomical distribution of sex steroid hormone receptors in the brain of female medaka (pages 1760–1780)

      Buntaro Zempo, Shinji Kanda, Kataaki Okubo, Yasuhisa Akazome and Yoshitaka Oka

      Version of Record online: 4 APR 2013 | DOI: 10.1002/cne.23255

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      Estrogen receptors (ERs) and androgen receptors (ARs) play crucial roles in coordinating reproductive functions. However, the distribution of these receptors has not been fully analyzed anatomically in the teleost brain. We analyzed the distribution of ERα, ERβ1, ERβ2, ARα, and ARβ mRNA by in situ hybridization in the brain of female medaka. All subtypes were expressed in the preoptic area and some other regions that are known to be involved in the regulation of sexual behavior or the hypothalamo-pituitary-gonadal axis.

    5. Transgenic labeling of higher order neuronal circuits linked to phospholipase C-β2–expressing taste bud cells in medaka fish (pages 1781–1802)

      Takashi Ieki, Shinji Okada, Yoshiko Aihara, Makoto Ohmoto, Keiko Abe, Akihito Yasuoka and Takumi Misaka

      Version of Record online: 4 APR 2013 | DOI: 10.1002/cne.23256

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      We generated transgenic medaka fish expressing a neuronal tracer, wheat germ agglutinin (WGA), under the control of the plc-β2 gene regulatory region to analyze the neuronal circuit connected to the taste sensory cells. WGA proteins expressed in the plc-β2-expressing taste bud cells (purple) were transported to a population of neurons in several ganglia and nuclei of the hindbrain at 12 days post fertilization (red), and in several brain regions including the diencephalon and telencephalon in fish that were 3 (orange) and 9 (green) months old. For abbreviations, see list in the text.

    6. Basal bodies exhibit polarized positioning in zebrafish cone photoreceptors (pages 1803–1816)

      Michelle Ramsey and Brian D. Perkins

      Version of Record online: 4 APR 2013 | DOI: 10.1002/cne.23260

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      The basal bodies (yellow) of blue-sensitive cone photoreceptors of the adult zebrafish retina exhibit planar polarization. Planar positioning is often critical for cilia function but has not been well documented in primary cilia or in sensory cilia such as photoreceptors. These results document a novel aspect of cilia positioning in vertebrate cones that is present only in adults, indicating that cellular mechanisms exist to position cilia actively.

    7. Cytoskeletal changes during development and aging in the cortex of neurofilament light protein knockout mice (pages 1817–1827)

      Yao Liu, Jerome A. Staal, Alison J. Canty, Matthew T. K. Kirkcaldie, Anna E. King, Olivier Bibari, Stan T. Mitew, Tracey C. Dickson and James C. Vickers

      Version of Record online: 4 APR 2013 | DOI: 10.1002/cne.23261

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      Neurofilament light (NFL) is an obligate subunit for neurofilament triplet intermediate filaments. We examined the effect of NFL knockout on the expression of cytoskeletal proteins in the cortex at 4 days, 5 months, and 12 months postnatally. Deleting NFL alters the expression of intermediate filament proteins, including α-internexin, and disrupts neurofilament assembly and transport, causing intracellular aggregation but no gross structural changes in cytoarchitecture. In addition, changes in expression of other cytoskeletal proteins may compensate for altered neurofilament expression.

    8. Periadolescent maturation of the prefrontal cortex is sex-specific and is disrupted by prenatal stress (pages 1828–1843)

      Julie A. Markham, Sylvina E. Mullins and James I. Koenig

      Version of Record online: 4 APR 2013 | DOI: 10.1002/cne.23262

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      Gestational stress is associated with increased risk for both cognitive deficits and schizophrenia, a psychiatric illness that emerges during adolescence and is more common among men. We find that maturation of prefrontal neurons follows a sex-specific pattern during normal development and that this pattern is disrupted during adolescence in prenatally stressed males. These findings may be relevant to both the development of normal sex differences in cognition and differential male–female vulnerability to mental illness.

    9. Hypothalamic and other connections with dorsal CA2 area of the mouse hippocampus (pages 1844–1866)

      Zhenzhong Cui, Charles R. Gerfen and W. Scott Young 3rd

      Version of Record online: 4 APR 2013 | DOI: 10.1002/cne.23263

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      We describe novel connections of a vasopressinergic projection from the paraventricular nuclei of the hypothalamus to the hippocampal CA2 and reciprocally between CA2 and supramammillary nuclei, suggesting regulatory roles for CA2 in social and emotional input for memory processing. We confirm CA2 afferents from neurons in the ipsilateral entorhinal cortex and bilateral dorsal CA2 and CA3 and CA2 efferents to bilateral medial septal, diagonal bands of Broca, and median raphe nuclei and to dorsal CA1, CA2, and CA3 bilaterally.

    10. Laminar and connectional organization of a multisensory cortex (pages 1867–1890)

      W. Alex Foxworthy, H. Ruth Clemo and M. Alex Meredith

      Version of Record online: 4 APR 2013 | DOI: 10.1002/cne.23264

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      For multisensory cortex, the laminar distribution of converging extrinsic, unisensory connections favors generation of multisensory properties for L2/3 neurons, as well as L5 neurons via their apical dendrites. Intrinsic translaminar connectivity also contributes to multisensory properties of L5 neurons. Few extrinsic or intrinsic projections reach L6, where most neurons are unisensory. Output targets of L2/3 and 5 are multisensory; output targets of L6 are mostly unisensory areas. These arrangements indicate parallel processing of unisensory and multisensory information within multisensory cortex.

    11. Efferent projections of neuropeptide Y-expressing neurons of the dorsomedial hypothalamus in chronic hyperphagic models (pages 1891–1914)

      Shin J. Lee, Melissa Kirigiti, Sarah R. Lindsley, Alberto Loche, Christopher J. Madden, Shaun F. Morrison, M. Susan Smith and Kevin L. Grove

      Version of Record online: 4 APR 2013 | DOI: 10.1002/cne.23265

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      The dorsomedial hypothalamic nucleus (DMH) is known to be involved in many homeostatic processes and to have broad projections throughout the hypothalamus and brainstem. In specific models of obesity and hyperphagia, neuropeptide Y neurons are activated within the DMH; however, the efferent projections of these neurons were unknown. We used anterograde tracers combined with histochemical analysis to demonstrate that NPY neurons in the DMH of both lactating rats and obese mice have strong projections within the hypothalamus, with limited projections to the brainstem.

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      De novo expression of neurokinin-1 receptors by spinoparabrachial lamina I pyramidal neurons following a peripheral nerve lesion (pages 1915–1928)

      Abeer W. Saeed and Alfredo Ribeiro-da-Silva

      Version of Record online: 4 APR 2013 | DOI: 10.1002/cne.23267

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      In normal rats, most spinal cord lamina I neurons of the pyramidal type projecting to the parabrachial nucleus are nonnociceptive, are sparsely innervated by substance P afferents, and do not express its receptor (the NK-1 receptor). We show that, in an animal model of neuropathic pain, most pyramidal neurons become innervated by substance P and express NK-1 receptors. These changes may be important for the understanding of neuropathic pain, as they suggest that pyramidal neurons may become nociceptive.