IB4-binding sensory neurons in the adult rat express a novel 3′ UTR-extended isoform of CaMK4 that is associated with its localization to axons (pages 308–336)
Benjamin J. Harrison, Robert M. Flight, Cynthia Gomes, Gayathri Venkat, Steven R. Ellis, Uma Sankar, Jeffery L. Twiss, Eric C. Rouchka and Jeffrey C. Petruska
Article first published online: 6 DEC 2013 | DOI: 10.1002/cne.23398
Sensory neurons of the DRG which bind the lectin IB4 are small-diameter, give rise to unmyelinated axons, and are generally cutaneous nociceptors. Using highly specific antibodies, we have demonstrated that CaMKIV is highly expressed in the cytoplasm and in axons arising from this IB4-binding population. In addition we have characterised a novel 3′ untranslated region (UTR)-extended transcript variant of this gene whose expression highly correlates with non-nuclear CaMKIV protein localization and IB4-binding. Possible mechanisms for, and functions of, axonally localised CaMKIV (a protein known for its function in the nucleus) in IB4-binding sensory neurons are discussed.