Journal of Comparative Neurology

Cover image for Vol. 522 Issue 2

01 February 2014

Volume 522, Issue 2

Pages Spc1–Spc1, 261–497

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      Distinctive population of Gfap-expressing neural progenitors arising around the dentate notch migrate and form the granule cell layer in the developing hippocampus (page Spc1)

      Tatsunori Seki, Toru Sato, Keiko Toda, Noriko Osumi, Tetsuya Imura and Seiji Shioda

      Article first published online: 6 DEC 2013 | DOI: 10.1002/cne.23508

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    1. Distinctive population of Gfap-expressing neural progenitors arising around the dentate notch migrate and form the granule cell layer in the developing hippocampus (pages 261–283)

      Tatsunori Seki, Toru Sato, Keiko Toda, Noriko Osumi, Tetsuya Imura and Seiji Shioda

      Article first published online: 6 DEC 2013 | DOI: 10.1002/cne.23460

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      The present analysis using Gfap-GFP transgenic mice has shown that distinctive Gfap-expressing progenitors arising around the dentate notch of the developing hippocampus form germinal regions in the migratory stream and the developing dentate gyrus where they differentiate into granule neurons, indicating that distinct astrocyte-like neural progenitors continue to generate granule neurons, from the beginning of dentate development and throughout life.

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    1. A new efficient method for synaptic vesicle quantification reveals differences between medial prefrontal cortex perforated and nonperforated synapses (pages 284–297)

      Nicoletta Nava, Fenghua Chen, Gregers Wegener, Maurizio Popoli and Jens Randel Nyengaard

      Article first published online: 6 DEC 2013 | DOI: 10.1002/cne.23482

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      By mean of serial section electron microscopy, we investigated the ultrastructure of two heterogeneous populations of excitatory synapses (perforated and nonperforated) within rodent medial prefrontal cortex. Combining design-based and model-based stereology, we show that presynaptic features, including pools of synaptic vesicles, active zone area, and presynaptic terminal volume, are highly correlated.

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    1. Role of plasma membrane estrogen receptors in mediating the estrogen induction of progesterone receptors in hypothalamic ventromedial neurons (pages 298–307)

      Susana I. Sá, Pedro A. Pereira, Viacheslav Malikov, Isabel M.P.L.V.O. Ferreira and M. Dulce Madeira

      Article first published online: 6 DEC 2013 | DOI: 10.1002/cne.23396

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      Ventromedial nucleus of the hypothalamus (VMN) regulates sexual behavior in female rodents by estrogenic induction of progesterone receptors expression. Stereological methods and Western blot analysis showed that membrane-initiated estradiol stimulation is able to induce progesterone receptor expression in the VMN. In addition, sequential administration of estradiol and estradiol conjugated with bovine serum albumin potentiates the effects resulting from the single administration of estradiol.

    2. IB4-binding sensory neurons in the adult rat express a novel 3′ UTR-extended isoform of CaMK4 that is associated with its localization to axons (pages 308–336)

      Benjamin J. Harrison, Robert M. Flight, Cynthia Gomes, Gayathri Venkat, Steven R. Ellis, Uma Sankar, Jeffery L. Twiss, Eric C. Rouchka and Jeffrey C. Petruska

      Article first published online: 6 DEC 2013 | DOI: 10.1002/cne.23398

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      Sensory neurons of the DRG which bind the lectin IB4 are small-diameter, give rise to unmyelinated axons, and are generally cutaneous nociceptors. Using highly specific antibodies, we have demonstrated that CaMKIV is highly expressed in the cytoplasm and in axons arising from this IB4-binding population. In addition we have characterised a novel 3′ untranslated region (UTR)-extended transcript variant of this gene whose expression highly correlates with non-nuclear CaMKIV protein localization and IB4-binding. Possible mechanisms for, and functions of, axonally localised CaMKIV (a protein known for its function in the nucleus) in IB4-binding sensory neurons are discussed.

    3. Neuropeptidome of Tribolium castaneum antennal lobes and mushroom bodies (pages 337–357)

      Marlene Binzer, Carsten M. Heuer, Martin Kollmann, Jorg Kahnt, Frank Hauser, Cornelis J.P. Grimmelikhuijzen and Joachim Schachtner

      Article first published online: 6 DEC 2013 | DOI: 10.1002/cne.23399

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      Using direct peptide profiling by MALDI-TOF mass spectrometry and immunohistological analysis, the authors characterized the neuropeptidome and distribution pattern of selected neuropeptides in the two major integrative olfactory neuropils, the antennal lobes and the mushroom bodies of Tribolium castaneum. This approach provided specific distinguishable neuropeptide expression profiles for both neuropils.

    4. Estrogen receptor β expression in the mouse forebrain: Age and sex differences (pages 358–371)

      Damian G. Zuloaga, Kristen L. Zuloaga, Laura R. Hinds, David L. Carbone and Robert J. Handa

      Article first published online: 6 DEC 2013 | DOI: 10.1002/cne.23400

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      We examined developmental sex differences in ERβ expression using male and female BAC-based Esr2-EGFP mice. When examined at postnatal day (P) 0, P4, and P21, dramatic variations in ERβ-EGFP expression were seen in several brain regions, including the cortex, hippocampus, and hypothalamus (e.g., paraventricular nucleus). Sex differences were found in the anteroventral periventricular nucleus and bed nucleus of the stria terminalis, with different ages at onset.

    5. Splicing factor TRA2B is required for neural progenitor survival (pages 372–392)

      Jacqueline M. Roberts, Hanane Ennajdaoui, Carina Edmondson, Brunhilde Wirth, Jeremy R. Sanford and Bin Chen

      Article first published online: 6 DEC 2013 | DOI: 10.1002/cne.23405

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      The authors demonstrate that the splicing factor TRA2B is required for neural progenitor cell survival. This conserved protein has been implicated in development and human diseases. Examinations of cortex-specific knockout mice reveal that loss of TRA2B results in apoptosis of neural progenitor cells and abnormal cerebral cortex development.

    6. Protein kinase C gamma interneurons in the rat medullary dorsal horn: Distribution and synaptic inputs to these neurons, and subcellular localization of the enzyme (pages 393–413)

      Cédric Peirs, Sudarshan Patil, Rabia Bouali-Benazzouz, Alain Artola, Marc Landry and Radhouane Dallel

      Article first published online: 6 DEC 2013 | DOI: 10.1002/cne.23407

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      Combining light and electron microscopic immunochemistry in the rat MDH, we show that PKCγ enzyme, involved in tactile allodynia, is concentrated at the plasma membranes, close to synaptic clefts, of specific lamina IIi neurons which receive myelinated, but not non-myelinated (including C-LTMR), afferents and contain both GABAAergic and glycinergic receptors.

    7. Serotonin-immunoreactive sensory neurons in the antenna of the cockroach Periplaneta americana (pages 414–434)

      Hidehiro Watanabe, Miki Shimohigashi and Fumio Yokohari

      Article first published online: 6 DEC 2013 | DOI: 10.1002/cne.23419

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      Using immunohistochemistry combined with retrograde staining, we identified serotonin-immunoreactive sensory neurons in the antenna of the cockroach Periplaneta americana on the light- and electronmicroscopic levels. Serotonin-immunoreactive sensory neurons are selectively distributed in cognate types of mechanosensory neurons housed in two different types of sensilla, chaetic and scolopidial sensilla. We also identified central projection patterns of these neurons. Our anatomical results revealed new peripheral sensory processings in insect. JO; Johnston's organ, CO; chordotonal organ, cam; campaniform sensillum, VN; ventral antennal nerve, DN; dorsal antennal nerve.

    8. Characterization of secretagogin-immunoreactive amacrine cells in marmoset retina (pages 435–455)

      Felix Weltzien, Stefano Dimarco, Dario A. Protti, Teresa Daraio, Paul R. Martin and Ulrike Grünert

      Article first published online: 6 DEC 2013 | DOI: 10.1002/cne.23420

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      In marmoset retina, secretagogin immunoreactivity can be found in a subpopulation of broad diffuse GABAergic amacrine cells. DiI injection into prelabeled cells showed that secretagogin positive amacrine cells have medium-sized dendritic fields. Thus, these cells share their stratification pattern with narrow-field amacrine cells and their neurotransmitter with wide-field amacrine cells.

    9. Regional innervation of the heart in the goldfish, Carassius auratus: A confocal microscopy study (pages 456–478)

      Cecilia M. Newton, Matthew R. Stoyek, Roger P. Croll and Frank M. Smith

      Article first published online: 6 DEC 2013 | DOI: 10.1002/cne.23421

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      All chambers of the heart in goldfish, a teleost, were innervated by the intracardiac nervous system. Most neuronal somata were located around the sinoatrial valves; half of these neurons were cholinergic. Putative pacemaker cells, identified by antibodies against hyperpolarization activated, cyclic nucleotide-gated channel 4, circumscribed the valves and were richly innervated. This arrangement constitutes the neuro-effector substrate for control of heart rate in teleosts.

    10. Parcellation of cerebellins 1, 2, and 4 among different subpopulations of dorsal horn neurons in mouse spinal cord (pages 479–497)

      Michael C. Cagle and Marcia G. Honig

      Article first published online: 6 DEC 2013 | DOI: 10.1002/cne.23422

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      Cblns are secreted proteins that bind to neurexins presynaptically and GluRδs postsynaptically to promote synapse formation. Here we show, by combining in situ hybridization with immunofluorescent staining, that Cblns 1, 2, and 4 are expressed by distinct subpopulations of excitatory neurons in the mouse dorsal spinal cord. Our results suggest that these neuronal subpopulations may vary in their ability to form synapses, based on the particular Cbln they express, and competitive interactions between their axons may contribute to the development of precise patterns of connectivity in the dorsal horn.

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