Outcomes of myocardial infarction hydrogel injection therapy in the human left ventricle dependent on injectate distribution

Authors

  • Renee Miller,

    1. Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town, Observatory, South Africa
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    • Whitaker Fellow

  • Neil H. Davies,

    1. Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town, Observatory, South Africa
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  • Jeroen Kortsmit,

    1. Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town, Observatory, South Africa
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    • §

      Claude Leon Postdoctoral Fellow

  • Peter Zilla,

    1. Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town, Observatory, South Africa
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  • Thomas Franz

    Corresponding author
    1. Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town, Observatory, South Africa
    2. Programme for the Enhancement of Research Capacity (PERC), Research Office, University of Cape Town, Mowbray, South Africa
    3. Centre for Research in Computational and Applied Mechanics, University of Cape Town, Rondebosch, South Africa
    4. Centre for High Performance Computing, Rosebank, South Africa
    • Correspondence to: Thomas Franz, Cardiovascular Research Unit, Faculty of Health Sciences, University of Cape Town, Private Bag X3, 7935 Observatory, South Africa.

      E-mail: thomas.franz@uct.ac.za

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SUMMARY

Myocardial infarction therapies involving biomaterial injections have shown benefits in inhibiting progression towards heart failure. However, the underlying mechanisms remain unclear. A finite element model of the human left ventricle was developed from magnetic resonance images. An anteroapical infarct was represented at acute (AI) and fibrotic (FI) stage. Hydrogel injections in the infarct region were modelled with layered (L) and bulk (B) distribution. In the FI, injectates reduced end-systolic myofibre stresses from 291.6% to 117.6% (FI-L) and 115.3% (FI-B) of the healthy value, whereas all AI models exhibited sub-healthy stress levels (AI: 90.9%, AI-L: 20.9%, AI-B: 30.5%). Reduction in end-diastolic infarct stress were less pronounced for both FI (FI: 294.1%, FI-L: 176.5%, FI-B: 188.2%) and AI (AI: 94.1%, AI-L: 35.3%, AI-B: 41.2%). In the border zone, injectates reduced end-systolic fibre stress by 8–10% and strain from positive (AI) and zero (FI) to negative. Layered and bulk injectates increased ejection fraction by 7.4% and 8.4% in AI and 14.1% and 13.7% in FI. The layered injectate had a greater impact on infarct stress and strain at acute stage, whereas the bulk injectate exhibited greater benefits at FI stage. These findings were confirmed by our previous in vivo results. Copyright © 2013 John Wiley & Sons, Ltd.

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