The first two authors contributed equally to this work. Therefore they can be both considered as first authors appearing in alphabetical order.
Paper Presented at WCCM 2012-10th World Congress on Computational Mechanics
Effects of deformation on transmural dispersion of repolarization using in silico models of human left ventricular wedge
Version of Record online: 23 JUN 2013
Copyright © 2013 John Wiley & Sons, Ltd.
International Journal for Numerical Methods in Biomedical Engineering
Volume 29, Issue 12, pages 1323–1337, December 2013
How to Cite
de Oliveira, B. L., Rocha, B. M., Barra, L. P. S., Toledo, E. M., Sundnes, J. and Weber dos Santos, R. (2013), Effects of deformation on transmural dispersion of repolarization using in silico models of human left ventricular wedge. Int. J. Numer. Meth. Biomed. Engng., 29: 1323–1337. doi: 10.1002/cnm.2570
- Issue online: 3 DEC 2013
- Version of Record online: 23 JUN 2013
- Manuscript Accepted: 8 NOV 2012
- Manuscript Received: 17 OCT 2012
- left ventricular wedge;
- human electromechanical model;
- mechanoelectrical feedback;
- transmural dispersion of repolarization;
Mechanical deformation affects the electrical activity of the heart through multiple feedback loops. The purpose of this work is to study the effect of deformation on transmural dispersion of repolarization and on surface electrograms using an in silico human ventricular wedge. To achieve this purpose, we developed a strongly coupled electromechanical cell model by coupling a human left ventricle electrophysiology model and an active contraction model reparameterized for human cells. This model was then embedded in tissue simulations on the basis of bidomain equations and nonlinear solid mechanics. The coupled model was used to evaluate effects of mechanical deformation on important features of repolarization and electrograms. Our results indicate an increase in the T-wave amplitude of the surface electrograms in simulations that account for the effects of cardiac deformation. This increased T-wave amplitude can be explained by changes to the coupling between neighboring myocytes, also known as electrotonic effect. The thickening of the ventricular wall during repolarization contributes to the decoupling of cells in the transmural direction, enhancing action potential heterogeneity and increasing both transmural repolarization dispersion and T-wave amplitude of surface electrograms. The simulations suggest that a considerable percentage of the T-wave amplitude (15%) may be related to cardiac deformation. Copyright © 2013 John Wiley & Sons, Ltd.