International Journal for Numerical Methods in Biomedical Engineering

Cover image for Vol. 28 Issue 12

December 2012

Volume 28, Issue 12

Pages 1165–1246

  1. Research Articles

    1. Top of page
    2. Research Articles
    1. Numerical treatment of boundary conditions to replace lateral branches in hemodynamics (pages 1165–1183)

      A. Porpora, P. Zunino, C. Vergara and M. Piccinelli

      Version of Record online: 5 JUN 2012 | DOI: 10.1002/cnm.2488

      Thumbnail image of graphical abstract

      We discuss how the weak enforcement of flow rate conditions in hemodynamics allows for cutting lateral branches from the computational domain and replacing them with given data on the mean flow rate. Both rigid and compliant vessel walls are considered. We also combine the present scheme with a stabilization method to control the flow reversal at outflow sections for pulsatile flows. The resulting scheme is successfully tested on a simplified model of aortic arch.

    2. Efficient biomarkers for the characterization of bone tissue (pages 1184–1197)

      J. E. Gil, J. P. Aranda, E. Mérida-Casermeiro and M. Ujaldón

      Version of Record online: 25 AUG 2012 | DOI: 10.1002/cnm.2505

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      We describe an expert system aimed to an accurate classification of bone tissue regeneration from stem cells. We analyze phenotype and color issues to build effective vectors of features for the subsequent characterization of tissue into five different classes: bone, cartilage, muscle, fiber and spine. Our study compares accuracy and computational time together with different stainings to reveal safranin blue as the best staining and multilayer perceptron as the most effective classifier.

    3. Geometric modeling of subcellular structures, organelles, and multiprotein complexes (pages 1198–1223)

      Xin Feng, Kelin Xia, Yiying Tong and Guo-Wei Wei

      Version of Record online: 21 NOV 2012 | DOI: 10.1002/cnm.2532

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      Minimum curvatures of six cryo-electron microscopy map entries. The regions with very small minimum curvature values are the potential targets of binding ligands.

    4. An improved baseline model for a human arterial network to study the impact of aneurysms on pressure-flow waveforms (pages 1224–1246)

      K. Low, R.  van Loon, I. Sazonov, R. L. T.  Bevan and P. Nithiarasu

      Version of Record online: 4 DEC 2012 | DOI: 10.1002/cnm.2533

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      A refined one-dimensional model for systemic blood flow circulation is presented. The results generated by the model are compared against in vivo measurements. The refined model is used for investigating the effect of embedding an aneurysm within a systemic blood flow network.