International Journal for Numerical Methods in Biomedical Engineering

Cover image for Vol. 28 Issue 8

August 2012

Volume 28, Issue 8

Pages 815–913

  1. Research Articles

    1. Top of page
    2. Research Articles
    1. Digital image correlation of bone sequential microscopic observations (pages 815–837)

      Elisa Budyn, Julien Jonvaux and Thierry Hoc

      Version of Record online: 8 FEB 2012 | DOI: 10.1002/cnm.1492

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      A method of image correlation is presented to study sequential microscopic observations of human Haversian cortical bone. Imaging biological tissues is sometimes challenging owing to their complex microstructures in particular when microcracks appear. Bone microfractures can be studied in micro compression tests where the progressive growth of small cracks is imaged by light microscopy. The two-dimensional displacement field on the sample surface is then tracked by various digital image correlation methods based on cross-correlation formulation.

    2. Iterative Sincconvolution method for solving planar D-bar equation with application to EIT (pages 838–860)

      Mahdi Abbasi and Ahmad-Reza Naghsh-Nilchi

      Version of Record online: 20 JAN 2012 | DOI: 10.1002/cnm.1495

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      The sinc-convolution method is employed to solve a two-dimensional D-bar equation of inverse scattering. Application of the proposed algorithm for solving planar D-bar equations that arise in the inverse conductivity problem on a numerically simulated chest phantom is considered. Results show that the sinc-convolution method solves D-bar equations and reconstructs the conductivity images with much higher accuracy and lower computational burden as compared with multigrid method, arguably the best of the existing numerical solution methods to D-bar equation.

    3. Simulation of ultrasonic wave propagation in anisotropic poroelastic bone plate using hybrid spectral/finite element method (pages 861–876)

      Vu-Hieu Nguyen and Salah Naili

      Version of Record online: 29 FEB 2012 | DOI: 10.1002/cnm.2462

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      This paper deals with the modeling of guided waves propagation in in vivo cortical long bone, which is known to be anisotropic medium with functionally graded porosity. The bone is modeled as an anisotropic poroelastic material by using Biot's theory formulated in high frequency domain. A hybrid spectral/finite element formulation has been developed to find the time-domain solution of ultrasonic waves propagating in a poroelastic plate immersed in two fluid halfspaces.

    4. A genetic algorithm tuned optimal controller for glucose regulation in type 1 diabetic subjects (pages 877–889)

      Subhojit Ghosh and Srihari Gude

      Version of Record online: 29 FEB 2012 | DOI: 10.1002/cnm.2466

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      A genetic algorithm tuned optimal state feedback is designed with the objective of minimizing the elevated glucose levels caused by meal intake in type 1 diabetic subjects, with the minimal subcutaneous infusion of insulin. The controller is based on the combined framework of linear quadratic regulation and Kalman filter. Simulation studies depict that the controller is able to maintain normoglycemia in diabetic subjects in case of meal intake of varying carbohydrate content, even with noisy glucose measurement and sensor delay.

    5. Computational modelling of cardiac electrophysiology: explanation of the variability of results from different numerical solvers (pages 890–903)

      P. Pathmanathan, M.O. Bernabeu, S.A. Niederer, D.J. Gavaghan and D. Kay

      Version of Record online: 28 FEB 2012 | DOI: 10.1002/cnm.2467

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      A recent verification study in the field of cardiac electrophysiological modelling compared 11 large-scale solvers and observed a surprising amount of variation between the solvers. By studying the numerical methods used, this paper fully explains the reasons for this variation, highlighting in particular a combination of approximations that magnifies error in the cardiac electrophysiological setting.

    6. Evaluation of mesh morphing and mapping techniques in patient specific modelling of the human pelvis (pages 904–913)

      Zoryana Salo, Maarten Beek and Cari Marisa Whyne

      Version of Record online: 29 FEB 2012 | DOI: 10.1002/cnm.2468

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      The objective of this study was to apply and evaluate mesh morphing and mapping techniques to facilitate the creation and structural analysis of specimen-specific FE models of the pelvis. A specimen-specific pelvic FE model (source mesh) was generated following a traditional user intensive meshing scheme.