International Journal for Numerical Methods in Biomedical Engineering

Cover image for Vol. 29 Issue 10

October 2013

Volume 29, Issue 10

Pages 1015–1160

  1. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling

    1. Top of page
    2. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    3. Review Article
    4. Paper Presented at WCCM 2012 - 10th World Congress on Computational Mechanics
    5. Paper Presented at ECCOMAS-3MBM-Multiscale and multiphysics modelling in bone mechanobiology
    6. Research Articles
    7. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    8. Research Articles
    9. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    1. Capillary networks in tumor angiogenesis: From discrete endothelial cells to phase-field averaged descriptions via isogeometric analysis (pages 1015–1037)

      Guillermo Vilanova, Ignasi Colominas and Hector Gomez

      Version of Record online: 7 MAY 2013 | DOI: 10.1002/cnm.2552

      Thumbnail image of graphical abstract

      In this paper, we develop a numerical method for a continuum-discrete, tumor-induced angiogenesis model. The formulation of the continuous description of the model involves high-order partial differential equations, which are solved by means of isogeometric analysis. The method couples the discrete mobile cells with the continuous description of the capillary network and allows us to perform several simulations that provide insight into the governing equations and the biological phenomenon.

  2. Review Article

    1. Top of page
    2. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    3. Review Article
    4. Paper Presented at WCCM 2012 - 10th World Congress on Computational Mechanics
    5. Paper Presented at ECCOMAS-3MBM-Multiscale and multiphysics modelling in bone mechanobiology
    6. Research Articles
    7. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    8. Research Articles
    9. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    1. Flow-induced ATP release in patient-specific arterial geometries – a comparative study of computational models (pages 1038–1056)

      E. Boileau, R. L. T. Bevan, I. Sazonov, M. I. Rees and P. Nithiarasu

      Version of Record online: 25 JUL 2013 | DOI: 10.1002/cnm.2581

      Thumbnail image of graphical abstract

      Distributed models for adenosine-5’-triphosphate (ATP) release aimed at describing the catalytic reactions at the endothelium are reviewed and critically examined. A general modelling framework is presented. Simulations performed on image-based patient-specific geometries reveal that existing paradigms may not account for the conditions encountered in vivo and may therefore not be adequate to model the kinetics of ATP at the endothelium.

  3. Paper Presented at WCCM 2012 - 10th World Congress on Computational Mechanics

    1. Top of page
    2. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    3. Review Article
    4. Paper Presented at WCCM 2012 - 10th World Congress on Computational Mechanics
    5. Paper Presented at ECCOMAS-3MBM-Multiscale and multiphysics modelling in bone mechanobiology
    6. Research Articles
    7. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    8. Research Articles
    9. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    1. Numerical analysis of non-Newtonian blood flow and wall shear stress in realistic single, double and triple aorto-coronary bypasses (pages 1057–1081)

      J. Vimmr, A. Jonášová and O. Bublík

      Version of Record online: 4 JUN 2013 | DOI: 10.1002/cnm.2560

      Thumbnail image of graphical abstract

      This paper presents a numerical investigation of pulsatile non-Newtonian blood flow in three different patient-specific aorto-coronary bypasses. The system of incompressible Navier–Stokes equations coupled with the Carreau–Yasuda model is numerically solved using the principle of the SIMPLE algorithm and cell-centred finite volume method formulated for hybrid unstructured tetrahedral grids. The numerical results discussed in this study indicate that the non-Newtonian blood flow in all of the considered bypass types does not significantly differ from the Newtonian one.

  4. Paper Presented at ECCOMAS-3MBM-Multiscale and multiphysics modelling in bone mechanobiology

    1. Top of page
    2. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    3. Review Article
    4. Paper Presented at WCCM 2012 - 10th World Congress on Computational Mechanics
    5. Paper Presented at ECCOMAS-3MBM-Multiscale and multiphysics modelling in bone mechanobiology
    6. Research Articles
    7. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    8. Research Articles
    9. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    1. Osteocytes are not only mechanoreceptive cells (pages 1082–1088)

      Gaël Y. Rochefort and Claude-Laurent Benhamou

      Version of Record online: 17 JUN 2013 | DOI: 10.1002/cnm.2561

      Thumbnail image of graphical abstract

      This paper presents the osteocyte functions. The osteocyte initiates and controls the local bone remodeling by mechanoreception and mechanotransduction, it monitors the local mineralization of the bone matrix, it controls the calcium homeostasis, it has an endocrine function and modulates the phosphate homeostasis, it modulates the proliferation and the tone of the skeletal striated muscle cells, and the osteocyte modulates the hematopoietic niche.

  5. Research Articles

    1. Top of page
    2. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    3. Review Article
    4. Paper Presented at WCCM 2012 - 10th World Congress on Computational Mechanics
    5. Paper Presented at ECCOMAS-3MBM-Multiscale and multiphysics modelling in bone mechanobiology
    6. Research Articles
    7. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    8. Research Articles
    9. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    1. Accurate determination of patient-specific boundary conditions in computational vascular hemodynamics using 3D cine phase-contrast MRI (pages 1089–1103)

      Y. Onishi, K. Aoki, K. Amaya, T. Shimizu, H. Isoda, Y. Takehara, H. Sakahara and T. Kosugi

      Version of Record online: 4 JUN 2013 | DOI: 10.1002/cnm.2562

      Thumbnail image of graphical abstract

      A method to determine the patient-specific boundary condition (BC) in vascular CFD analysis using 4D Flow velocimetry is proposed. Our method corrects the raw 4D Flow velocity data, which is inaccurate and thus unsuitable to be directly assigned as the patient-specific BC. This paper shows the stochastic error characteristics of 4D Flow velocimetry, the correction algorithm to determine the patient-specific BC, and the phantom studies to validate our method.

  6. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling

    1. Top of page
    2. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    3. Review Article
    4. Paper Presented at WCCM 2012 - 10th World Congress on Computational Mechanics
    5. Paper Presented at ECCOMAS-3MBM-Multiscale and multiphysics modelling in bone mechanobiology
    6. Research Articles
    7. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    8. Research Articles
    9. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    1. Computational modeling of chemo-electro-mechanical coupling: A novel implicit monolithic finite element approach (pages 1104–1133)

      J. Wong, S. Göktepe and E. Kuhl

      Version of Record online: 24 JUN 2013 | DOI: 10.1002/cnm.2565

      Thumbnail image of graphical abstract

      A healthy heartbeat is generated by interacting chemical, electrical, and mechanical fields. Whereas existing approaches solve each field with a different algorithm, we propose a unified, implicit, monolithic algorithm to solve all fields simultaneously. We demonstrate that this novel approach is unconditionally stable, computationally efficient, highly modular, geometrically flexible, and easily expandable.

  7. Research Articles

    1. Top of page
    2. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    3. Review Article
    4. Paper Presented at WCCM 2012 - 10th World Congress on Computational Mechanics
    5. Paper Presented at ECCOMAS-3MBM-Multiscale and multiphysics modelling in bone mechanobiology
    6. Research Articles
    7. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    8. Research Articles
    9. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    1. Numerical simulation of dental bone remodeling induced by implant-supported fixed partial denture with or without cantilever extension (pages 1134–1147)

      Chao Wang, Qing Li, Colin McClean and Yubo Fan

      Version of Record online: 19 JUL 2013 | DOI: 10.1002/cnm.2579

      Thumbnail image of graphical abstract

      This study aims to evaluate and compare the bony biomechanical response stemming from the use of two-unit fixed partial dentures (FPDs) with or without cantilever configuration. The results revealed that the biomechanical performance of a cantilever FPD is rather different from that of a non-cantilever structure, especially under overload conditions. Bone overload resorption was more severe in the cortical neck around the cantilever FPD, as compared with the non-cantilever configuration, which is better for maintaining the overall health of bone.

  8. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling

    1. Top of page
    2. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    3. Review Article
    4. Paper Presented at WCCM 2012 - 10th World Congress on Computational Mechanics
    5. Paper Presented at ECCOMAS-3MBM-Multiscale and multiphysics modelling in bone mechanobiology
    6. Research Articles
    7. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    8. Research Articles
    9. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    1. Transient stress-based and strain-based hemolysis estimation in a simplified blood pump (pages 1148–1160)

      Lutz Pauli, Jaewook Nam, Matteo Pasquali and Marek Behr

      Version of Record online: 6 AUG 2013 | DOI: 10.1002/cnm.2576

      Thumbnail image of graphical abstract

      We compare two approaches to numerical estimation of mechanical hemolysis in a simplified blood pump. The stress-based model relies on the instantaneous shear stress in the blood flow, whereas the strain-based model uses an additional tensor equation to relate distortion of red blood cells to a shear stress measure. The stress-based model overestimates the rate of hemolysis, whereas the strain-based model is found to deliver lower hemolysis rates because it incorporates a more detailed description of biophysical phenomena into the simulation process.

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