Simulation of oxygen transfer in stented arteries and correlation with in-stent restenosis (pages 1373–1387)
M. Caputo, C. Chiastra, C. Cianciolo, E. Cutrì, G. Dubini, J. Gunn, B. Keller, F. Migliavacca and P. Zunino
Version of Record online: 29 AUG 2013 | DOI: 10.1002/cnm.2588
We investigate the influence of geometrical factors, such as curvature (the radius of curvature decreases from 36 to 20 mm for models labeled as CU36 and CU20), biomechanical stimuli on in-stent restenosis after percutaneous coronary intervention. We combine in silico models for blood flow and oxygen transport in a realistic model of porcine coronary artery reconstructed from micro-computed tomography with histological observation available from an animal model. Our findings suggest that low wall shear stress and reduced oxygen concentrations positively correlate with the risk of neointimal hyperplasia.