International Journal for Numerical Methods in Biomedical Engineering

Cover image for Vol. 29 Issue 12

December 2013

Volume 29, Issue 12

Pages 1307–1455

  1. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology

    1. Top of page
    2. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology
    3. Paper Presented at WCCM 2012-10th World Congress on Computational Mechanics
    4. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology
    5. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    6. Research Articles
    1. Endocortical bone loss in osteoporosis: the role of bone surface availability (pages 1307–1322)

      Pascal R. Buenzli, C. David L. Thomas, John G. Clement and Peter Pivonka

      Version of Record online: 1 JUL 2013 | DOI: 10.1002/cnm.2567

      Thumbnail image of graphical abstract

      We present a spatio-temporal computational model of bone remodelling that includes feedback from the bone microstructure on the bone-forming and bone-resorbing cells. The model is used to evolve the distribution of bone volume fraction in a midshaft cross section under an assumed osteoporotic condition. Simulated rates of endocortical bone losses are compatible with rates of cortical thinning observed from human femur cross-sectional data.

  2. Paper Presented at WCCM 2012-10th World Congress on Computational Mechanics

    1. Top of page
    2. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology
    3. Paper Presented at WCCM 2012-10th World Congress on Computational Mechanics
    4. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology
    5. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    6. Research Articles
    1. Effects of deformation on transmural dispersion of repolarization using in silico models of human left ventricular wedge (pages 1323–1337)

      B. L. de Oliveira, B. M. Rocha, L. P. S. Barra, E. M. Toledo, J. Sundnes and R. Weber dos Santos

      Version of Record online: 23 JUN 2013 | DOI: 10.1002/cnm.2570

      Thumbnail image of graphical abstract

      This paper presents a strongly coupled electromechanical cell model embedded in tissue simulations on the basis of bidomains equations and nonlinear solid mechanics. The coupled model was used to evaluate effects of mechanical deformation on important features of repolarization and electrograms. Our results indicate that the thickening of the ventricular wall during repolarization contributes to the decoupling of cells in the transmural direction, enhancing action potential heterogeneity and increasing both transmural dispersion of repolarization and T-wave amplitude of computed surface electrograms.

  3. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology

    1. Top of page
    2. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology
    3. Paper Presented at WCCM 2012-10th World Congress on Computational Mechanics
    4. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology
    5. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    6. Research Articles
    1. Power-law hereditariness of hierarchical fractal bones (pages 1338–1360)

      Luca Deseri, Mario Di Paola, Massimiliano Zingales and Pietro Pollaci

      Version of Record online: 8 JUL 2013 | DOI: 10.1002/cnm.2572

      Thumbnail image of graphical abstract

      In this paper, a hierarchic fractal model is introduced to describe bone hereditariness. Although bones are not true fractal, because they do not posses a self-similar organization at every resolution scale, the obtained model delivers a very good approximation of their overall viscoelastic properties. Their experimental values are shown to be well described power-laws creep/relaxation functions obtained upon introducing a fractal description of bone cross-section and showing how the associated Hausdorff dimension is related to the exponent of the power law.

    2. Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes (pages 1361–1372)

      Ted J. Vaughan, Stefaan W. Verbruggen and Laoise M. McNamara

      Version of Record online: 29 JUL 2013 | DOI: 10.1002/cnm.2578

      Thumbnail image of graphical abstract

      A multiscale model of cortical bone is developed that characterises the local stimulus experienced by osteocytes distributed throughout the tissue structure. We predict that an inhomogeneous microstructural strain field contributes to osteocytes receiving vastly different stimuli at the cellular level, depending on their location within the microstructure. These findings indicate that osteocytes are not equal in terms of the mechanical stimulus being received, and we propose that only a subset of osteocytes may be sufficiently stimulated to function as mechanoreceptors.

  4. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling

    1. Top of page
    2. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology
    3. Paper Presented at WCCM 2012-10th World Congress on Computational Mechanics
    4. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology
    5. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    6. Research Articles
    1. Simulation of oxygen transfer in stented arteries and correlation with in-stent restenosis (pages 1373–1387)

      M. Caputo, C. Chiastra, C. Cianciolo, E. Cutrì, G. Dubini, J. Gunn, B. Keller, F. Migliavacca and P. Zunino

      Version of Record online: 29 AUG 2013 | DOI: 10.1002/cnm.2588

      Thumbnail image of graphical abstract

      We investigate the influence of geometrical factors, such as curvature (the radius of curvature decreases from 36 to 20 mm for models labeled as CU36 and CU20), biomechanical stimuli on in-stent restenosis after percutaneous coronary intervention. We combine in silico models for blood flow and oxygen transport in a realistic model of porcine coronary artery reconstructed from micro-computed tomography with histological observation available from an animal model. Our findings suggest that low wall shear stress and reduced oxygen concentrations positively correlate with the risk of neointimal hyperplasia.

  5. Research Articles

    1. Top of page
    2. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology
    3. Paper Presented at WCCM 2012-10th World Congress on Computational Mechanics
    4. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology
    5. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    6. Research Articles
    1. Well-balanced high-order solver for blood flow in networks of vessels with variable properties (pages 1388–1411)

      Lucas O. Müller and Eleuterio F. Toro

      Version of Record online: 31 JUL 2013 | DOI: 10.1002/cnm.2580

      Thumbnail image of graphical abstract

      We present a well-balanced, high-order non-linear numerical scheme for solving one-dimensional blood flow in vessels with variable properties. Using a suitable set of test problems with exact solution, we rigorously assess the well-balanced property, the effective order of accuracy and the ability to solve unsteady problems. The numerical methodology is then validated against published state-of-the-art numerical solutions and experimental measurements. The efficiency and robustness of the present scheme makes it suitable for modelling both arteries and veins.

    2. Finite element analysis on longitudinal and radial functionally graded femoral prosthesis (pages 1412–1427)

      Azim Ataollahi Oshkour, N. A Abu Osman, M. M. Davoodi, Y. H. Yau, F. Tarlochan, W. A. B Wan Abas and M. Bayat

      Version of Record online: 6 AUG 2013 | DOI: 10.1002/cnm.2583

      Thumbnail image of graphical abstract

      Strain energy increased proportionally with increasing volume fraction gradient exponent, whereas the stresses decreased on the prostheses surfaces. A limited stress increase was also observed at the surfaces of the bone and cement. The periprosthetic femur with a noncemented prostheses exhibited higher strain energy than with a cemented prostheses. Radial prostheses implantation displayed more strain energy than longitudinal prostheses implantation in the femoral proximal part.

    3. Graphics processing unit accelerated one-dimensional blood flow computation in the human arterial tree (pages 1428–1455)

      Lucian Itu, Puneet Sharma, Ali Kamen, Constantin Suciu and Dorin Comaniciu

      Version of Record online: 5 SEP 2013 | DOI: 10.1002/cnm.2585

      Thumbnail image of graphical abstract

      We propose a numerical implementation based on a graphics processing unit (GPU) for the acceleration of the execution time of one-dimensional blood flow models. A parallel hybrid CPU-GPU algorithm and a parallel GPU only (PGO) algorithm are developed, which are compared against a single-threaded CPU only (SCO) algorithm and a multi-threaded CPU only (MCO) algorithm. Different numerical solution schemes and computational setups are tested, and the PHCG and PGO algorithms significantly improve the execution time of the SCO and MCO algorithms.

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